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Cited by 58Rabies epidemiology and controlSleep and Wakefulness ResearchInfectious Encephalopathies and Encephalitis

Sleep alterations in experimental street rabies virus infection occur in the absence of major EEG abnormalities

Gourmelon, Patrick, Briet, Dominique, Clarençon, Didier, Court, Louis, Tsiang, Henri·1991·Brain Research
DOI 10.1016/0006-8993(91)90184-w
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Abstract

Brain electrical activity and sleep organization were investigated in chronically implanted mice during street rabies virus infection. Continuous EEG recordings showed no gross electrical abnormalities until a few hours before the fatal issue. In contrast, alterations of sleep stages were observed at an early stage during the course of rabies virus infection, at a time when clinical signs were absent. Quantification by spectral analysis showed that the main feature was the early decrease of REM-sleep stages and the increase of the duration of waking stages. Neuromuscular disorders which could occur early were also observed during the disease. Comparison of these data with those obtained from fixed rabies virus infection shows that in the latter the EEG recordings demonstrated early alterations and a progressive deterioration with disappearance of both sleep and waking stages, which were replaced by a pathological sleep stage. In order to evaluate the potential role of the host-specific immune response in promoting brain electrophysiological alterations, EEG recordings and spectral analysis were also performed in cyclophosphamide-treated mice. Street rabies virus-infected and immunosuppressed mice showed identical physiopathological changes as those observed in immunocompetent mice. The implication of these viral-induced electrophysiological alterations in the context of the pathogenic mechanisms of rabies virus is discussed.

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  • CNS viral diseases such as rabies or viral encephalitis in rodents are associated with altered sleep.

    “CNS viral diseases, such as rabies (Gourmelon et al, 1991) or viral encephalitis in rodents after vesicular stomatitis virus infection (Machida et al, 2014), are associated with altered sleep.”

    From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Gourmelon et al, 1991

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Authors
Gourmelon, P., Briet, D., Clarençon, D., Court, L., & Tsiang, H.
Affiliations
  • Institut Pasteur (FR)
  • Service de Santé des Armées (FR)
Corresponding author
Tsiang, Henri
Venue
Brain Research
Publisher
Elsevier BV
Published
1991-07
Volume
554
Issue
1-2
Pages
159-165
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(91)90184-w
OpenAlex
W1987549775
Cited by
58
References
41
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2018: 1 · 2016: 4 · 2015: 1 · 2013: 2 · 2012: 1
FWCI
0.45
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › Rabies epidemiology and control
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Keywords
rabies virus, sleep disorders, REM sleep, EEG abnormalities, sleep stages, neuromuscular disorders, cyclophosphamide, immunosuppression, host immune response, chronic infection, mice
MeSH terms
Animals, Brain, Cyclophosphamide, Electroencephalography, Electromyography, Electrooculography, Foxes, Mice, Inbred C3H, Mice, Inbred C57BL, Rabies, Rabies virus, Sleep, Sleep, REM, Mice

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