Sleep and behavior during vesicular stomatitis virus induced encephalitis in BALB/cJ and C57BL/6J mice
Open accessAbstract
Intranasal application of vesicular stomatitis virus (VSV) produces a well-characterized model of viral encephalitis in mice. Within one day post-infection (PI), VSV travels to the olfactory bulb and, over the course of 7 days, it infects regions and tracts extending into the brainstem followed by clearance and recovery in most mice by PI day 14 (PI 14). Infectious diseases are commonly accompanied by excessive sleepiness; thus, sleep is considered a component of the acute phase response to infection. In this project, we studied the relationship between sleep and VSV infection using C57BL/6 (B6) and BALB/c mice. Mice were implanted with transmitters for recording EEG, activity and temperature by telemetry. After uninterrupted baseline recordings were collected for 2 days, each animal was infected intranasally with a single low dose of VSV (5×10(4) PFU). Sleep was recorded for 15 consecutive days and analyzed on PI 0, 1, 3, 5, 7, 10, and 14. Compared to baseline, amounts of non-rapid eye movement sleep (NREM) were increased in B6 mice during the dark period of PI 1-5, whereas rapid eye movement sleep (REM) was significantly reduced during the light periods of PI 0-14. In contrast, BALB/c mice showed significantly fewer changes in NREM and REM. These data demonstrate sleep architecture is differentially altered in these mouse strains and suggests that, in B6 mice, VSV can alter sleep before virus progresses into brain regions that control sleep.
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CNS viral diseases such as rabies or viral encephalitis in rodents are associated with altered sleep.
“CNS viral diseases, such as rabies (Gourmelon et al, 1991) or viral encephalitis in rodents after vesicular stomatitis virus infection (Machida et al, 2014), are associated with altered sleep.”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Machida et al, 2014
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Sleep health: Reciprocal regulation of sleep and innate immunity
Irwin, M. R., & Opp, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.148 · Cited by 624 · see citing works
- Authors
- Machida, M., Ambrozewicz, M. A., Breving, K., Wellman, L. L., Yang, L., Ciavarra, R. P., & Sanford, L. D.
- Affiliations
- Eastern Virginia Medical School (US)
- Corresponding author
- Sanford, Larry D.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 35
- Pages
- 125-134
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3959631
- OpenAlex
- W2060432665
- Cited by
- 10
- References
- 75
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 3 · 2017: 1 · 2016: 4
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eastern Virginia Medical School
- National Institutes of Health
- National Institute of Nursing Research (NR011519, R21NR011519)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- vesicular stomatitis virus, viral encephalitis, sleep architecture, NREM sleep, REM sleep, intranasal infection, strain differences, BALB/c mice, C57BL/6 mice, sleep-wake behavior, acute phase response
- MeSH terms
- Animals, Behavior, Animal, Electroencephalography, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Sleep, Sleep, REM, Vesicular stomatitis Indiana virus, Rhabdoviridae Infections, Encephalitis, Viral, Mice
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