Cited by 438Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behaviorNeuroscience and Neuropharmacology Research

Sexual behavior enhances central dopamine transmission in the male rat

Pfaus, J.G., Damsma, G., Nomikos, G.G., Wenkstern, D.G., Blaha, C.D., Phillips, A.G., Fibiger, H.C.·1990·Brain Research

Abstract

Central dopamine transmission was examined in the nucleus accumbens and striatum of sexually experienced male rats during mating behaviour using in vivo brain microdialysis. Dopamine release increased significantly in the nucleus accumbens when males were placed in a novel mating chamber and when a receptive female was introduced behind a screen partitioning this chamber. Subsequently, during copulation dopamine transmission increased sharply, this being followed by a gradual decrease after the female was removed. In contrast, striatal dopamine transmission increased significantly only during copulation. These data provide a neurochemical basis for the well-known interactions between dopaminergic drugs and male sexual behaviour and demonstrate the feasibility of using brain microdialysis to elucidate the neurochemical correlates of motivated behaviour.

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Crossref · 10.1016/0006-8993(90)91309-5

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24 of 24 references verified0 citation errors · 0 not checkable

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  • Studies examining extracellular dopamine within the nucleus accumbens observe enhanced dopamine concentrations when shown a sexually receptive female behind a screen.

    “Studies examining extracellular dopamine within the nucleus accumbens observe enhanced dopamine concentrations when shown a sexually receptive female behind a screen (Damsma et al., 1992, Pfaus et al., 1990).”

    From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Pfaus et al., 1990

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Authors
Pfaus, J. G., Damsma, G., Nomikos, G. G., Wenkstern, D. G., Blaha, C. D., Phillips, A. G., & Fibiger, H. C.
Affiliations
University of British Columbia (CA)
Corresponding author
Fibiger, H.C.
Venue
Brain Research
Publisher
Elsevier BV
Published
1990-10
Volume
530
Issue
2
Pages
345-348
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2095849459
Cited by
438
References
24
Citations by year
2026: 4 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 15 · 2021: 4 · 2020: 56 · 2019: 12 · 2018: 16 · 2017: 11 · 2016: 6 · 2015: 16 · 2014: 14 · 2013: 14 · 2012: 11
FWCI
4.25
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
sexual behavior, dopamine release, nucleus accumbens, striatum, copulation, mating behavior, male rats, cerebral microdialysis, dopaminergic therapy, motivated behavior
MeSH terms
Animals, Brain Chemistry, Corpus Striatum, Dialysis, Dopamine, Female, Male, Motor Activity, Synaptic Transmission, Nucleus Accumbens, Sexual Behavior, Animal, Stereotaxic Techniques, Rats

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