Distribution of Fos immunoreactivity following mating versus anogenital investigation in the male rat brain
Open accessAbstract
In the present study a detailed quantitative analysis was made using Fos as a marker for neural activation to define which subregions in the neural circuitry underlying male sexual behavior are involved in display of anogenital investigation versus copulation. Neural activity was differentially distributed following anogenital investigation versus mating and was restricted to specific subdivisions that form a heavily interconnected network. Chemosensory investigation increased neural activity in the posteromedial subdivision of the bed nucleus of the stria terminalis and the posterodorsal subdivision of the medial amygdala, brain regions that receive chemosensory signals processed through the olfactory bulbs, presumably reflecting the acquisition of chemosensory signals or the display of anogenital investigation. However, other sensory signals or sexual experience may also have contributed to the induction of neural activation in these brain areas. Moreover, consummatory behavior increased neural activity in the subparafascicular nucleus, a brain region that receives genital sensory inputs. In turn, this brain region projects to the medial preoptic nucleus and posterior nucleus of the amygdala, where neural activity was also abundant only following copulation. In addition, clusters of neurons were activated in the posteromedial subdivision of the bed nucleus of the stria terminalis and posterodorsal subdivision of the medial amygdala following consummatory behavior. The present study provides an anatomically detailed picture about the distribution of neural activation following sexual behavior in the rat, specifically in relation to differences following anogenital investigation versus mating.
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The role of the PIL in sexual behavior is supported by earlier work showing increased c-fos-immunoreactivity following ejaculation in male rats and vaginocervical stimulation in female rats in the SPFp.
“The role of the PIL in sexual behavior is supported by earlier work showing increased c-fos-immunoreactivity following ejaculation in male rats and vaginocervical stimulation in female rats in the SPFp (31-33).”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [32]
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- Authors
- Coolen, L. M., Peters, H. J. P. W., & Veening, J. G.
- Affiliations
- Radboud University Nijmegen (NL)
- Corresponding author
- Coolen, L.M
- ORCID
- Coolen, L.M
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 77
- Issue
- 4
- Pages
- 1151-1161
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2098981397
- Cited by
- 166
- References
- 50
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 8 · 2012: 8
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- Fos-like immunoreactivity, male sexual behavior, copulation, neuronal activation, bed nucleus of the stria terminalis, medial amygdala, medial preoptic nucleus, olfactory bulb, consummatory behavior, mating behavior, rat brain
- MeSH terms
- Amygdala, Animals, Anal Canal, Brain Chemistry, Female, Male, Mesencephalon, Penis, Preoptic Area, Sexual Behavior, Animal, Thalamic Nuclei, Proto-Oncogene Proteins c-fos, Rats, Wistar, Rats
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