Cited by 124Neuroscience and Neuropharmacology ResearchCancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

The astrocyte-neuron lactate shuttle: a challenge of a challenge

Open access
Hertz, Leif·2004·Journal of Cerebral Blood Flow & Metabolism

Integrity signals

Registry

Crossref · 10.1097/00004647-200411000-00008

Cites

104 of 104 references verified0 citation errors · 0 not checkable

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  • The astrocyte-to-neuron lactate shuttle (ANLS) hypothesis has been quite controversial for a long time.

    “The ANLS hypothesis has been quite controversial for a long time (Chih et al., 2001; Gjedde and Marrett, 2001; Hertz, 2004; Mangia et al., 2011; Dienel, 2012, 2017; Bak and Walls, 2018; Barros and Weber, 2018; see also Dienel [2017] for strong arguments against ANLS at the tissue level).”

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Authors
Hertz, L.
Affiliations
University of Saskatchewan (CA)
Corresponding author
Hertz, Leif
Venue
Journal of Cerebral Blood Flow & Metabolism
Published
2004-11
Volume
24
Issue
11
Pages
1241-1248
ISSN
  • 0271-678X (ISSN-L)
  • 1559-7016
OpenAlex
W2048453304
Cited by
124
References
104
Citations by year
2026: 5 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 10 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 12
FWCI
2.94
Type
journal article
Language
en
Open access
Locations
  • Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
astrocyte-neuron lactate shuttle, lactate transport, astrocytes, neurons, brain energy metabolism, glucose metabolism
MeSH terms
Animals, Astrocytes, Biological Transport, Brain, Glycolysis, Humans, Lactates, Neurons, Oxidation-Reduction, Oxygen, Glutamic Acid, Extracellular Fluid

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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