The astrocyte-neuron lactate shuttle: a challenge of a challenge
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The astrocyte-to-neuron lactate shuttle (ANLS) hypothesis has been quite controversial for a long time.
“The ANLS hypothesis has been quite controversial for a long time (Chih et al., 2001; Gjedde and Marrett, 2001; Hertz, 2004; Mangia et al., 2011; Dienel, 2012, 2017; Bak and Walls, 2018; Barros and Weber, 2018; see also Dienel [2017] for strong arguments against ANLS at the tissue level).”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Hertz, 2004
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“The ANLS hypothesis continues to generate controversy in the literature (Hertz, 2004; Chuquet et al., 2010; Patel et al., 2014; Lundgaard et al., 2015).”
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“Astrocytes can indeed produce lactate from glucose (Hertz et al., 1988; Magistretti et al., 1993), and this lactate production can be stimulated by glutamate and potassium, which become elevated during neuronal activity (Walz and Mukerji, 1988; Peng et al., 1994; Pellerin and Magistretti, 1996;…”
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Astrocytic contributions to bioenergetics of cerebral ischemia
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Self-citationThe redox switch/redox coupling hypothesis
Cerdán, S., Rodrigues, T. B., Sierra, A., Benito, M., Fonseca, L. L., Fonseca, C. P., & García-Martín, M. L. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.036 · Cited by 146 · see citing works
Aerobic glycolysis in the primate brain: Reconsidering the implications for growth and maintenance
Bauernfeind, A. L., Barks, S. K., Duka, T., Grossman, L. I., Hof, P. R., & Sherwood, C. C. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0662-z · Cited by 105 · see citing works
From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition
Young, A. M. H., Chakrabarti, B., Roberts, D., Lai, M.-C., Suckling, J., & Baron-Cohen, S. (2016) · Molecular Autism · doi:10.1186/s13229-016-0068-x · Cited by 76 · see citing works
Yoo, I. D., Park, M. W., Cha, H. W., Yoon, S., Boonpraman, N., Yi, S. S., & Moon, J.-S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217862 · Cited by 51 · see citing works
- Authors
- Hertz, L.
- Affiliations
- University of Saskatchewan (CA)
- Corresponding author
- Hertz, Leif
- ORCID
- Hertz, Leif
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2004-11
- Volume
- 24
- Issue
- 11
- Pages
- 1241-1248
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2048453304
- Cited by
- 124
- References
- 104
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 10 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 12
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- astrocyte-neuron lactate shuttle, lactate transport, astrocytes, neurons, brain energy metabolism, glucose metabolism
- MeSH terms
- Animals, Astrocytes, Biological Transport, Brain, Glycolysis, Humans, Lactates, Neurons, Oxidation-Reduction, Oxygen, Glutamic Acid, Extracellular Fluid
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