The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain
Abstract
We have examined the distribution of 5-HT1A and 5-HT2A receptor mRNAs in post-mortem human hippocampus, neocortex, raphe nuclei, cerebellum and basal ganglia using in situ hybridization histochemistry. Receptor transcripts in brains from two males and two females (mean age +/- S.D. = 70 +/- 4 years; post-mortem interval = 29 +/- 6 h) were visualised with 35S-radiolabelled synthetic oligodeoxyribonucleic acid probes. In the hippocampus, 5-HT1A receptor mRNA was present in all fields, especially CA1. In the parahippocampal gyrus and neocortical regions 5-HT1A receptor mRNA was enhanced in superficial and middle laminae. 5-HT1A receptor mRNA was particularly abundant in the raphe and other serotonergic cell groups of the brainstem. The analysis of emulsion dipped sections showed 5-HT1A receptor mRNA to be concentrated in pyramidal neurons, together with the granule cells of the dentate gyrus. In neocortical areas lamina III pyramidal neurons were more heavily labelled than those in lamina V. There was no evidence of glial expression of 5-HT1A receptor mRNA in grey matter or white matter compartments. 5-HT2A receptor mRNA was present in all neocortical areas examined, where it was located in pyramidal neurons, of lamina V more than in those of lamina III, as well as in putative interneurons, especially within lamina IVc of the striate cortex. 5-HT2A receptor mRNA was observed at minimal levels in the hippocampus and not in the raphe. Neither 5-HT1A nor 5-HT2A receptor mRNA were detected in the cerebellum, substantia nigra or striatum. The ability to detect these transcripts at the regional and cellular level will help reveal important details of the 5-HT receptor system in the human brain. This includes the investigation of their putative roles in the normal chemoarchitecture and in pathophysiological brain processes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A similar pattern of 5-HT2A receptor expression has been shown in human post-mortem tissue using both autoradiography and in situ hybridization.
“A similar pattern of 5-HT2A receptor expression has been shown in human post-mortem tissue using both autoradiography (211) and in situ hybridization (212).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [212]
Cites
THE BASIC UNIFORMITY IN STRUCTURE OF THE NEOCORTEX
Röckel, A., Hiorns, R. W., & Powell, T. P. S. (1980) · Brain · doi:10.1093/brain/103.2.221 · Cited by 902 · see citing works
Pompeiano, M., Palacios, J. M., & Mengod, G. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90223-2 · Cited by 870 · see citing works
Pompeiano, M., Palacios, J., & Mengod, G. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00440.1992 · Cited by 699 · see citing works
Serotonin receptors in the human brain—III. Autoradiographic mapping of serotonin-1 receptors
Pazos, Á., Probst, A., & Palacios, J. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90326-5 · Cited by 684 · see citing works
Zifa, E., & Fillion, G. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(01)80026-2 · Cited by 677 · see citing works
Molecular biology of 5-HT receptors
Boess, F., & Martin, I. L. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90059-0 · Cited by 675 · see citing works
Araneda, R. C., & Andrade, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90128-b · Cited by 621 · see citing works
Peroutka, S. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03166.x · Cited by 524 · see citing works
Kobilka, B. K., Frielle, T., Collins, S., Yang-Feng, T. L., Kobilka, T. S., Francke, U., Lefkowitz, R. J., & Caron, M. G. (1987) · Nature · doi:10.1038/329075a0 · Cited by 515 · see citing works
Chalmers, D. T., & Watson, S. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90748-k · Cited by 388 · see citing works
Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors
Pazos, A., Probst, A., & Palacios, J. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90327-7 · Cited by 355 · see citing works
Serotonin Uptake Sites and Serotonin Receptors Are Altered in the Limbic System of Schizophrenics
Joyce, J. N., Shane, A. L., Lexow, N., Winokur, A., Casanova, M. F., & Kleinman, J. E. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.32 · Cited by 340 · see citing works
Hrdina, P. D., Demeter, E., Vu, T. B., Sótonyi, P., & Palkovits, M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91015-k · Cited by 327 · see citing works
OʼKusky, J. R., & Colonnier, M. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902100307 · Cited by 327 · see citing works
Pre‐and Postmortem Influences on Brain RNA
BARTON, A. J. L., Pearson, R. C. A., Najlerahim, A., & Harrison, P. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03532.x · Cited by 269 · see citing works
Self-citationSelective Abnormalities of Prefrontal Serotonergic Receptors in Schizophrenia
Laruelle, M. A. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820220066007 · Cited by 235 · see citing works
Morilak, D. A., Garlow, S. J., & Ciaranello, R. D. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90241-7 · Cited by 231 · see citing works
Francis, P. T., Sims, N. R., PROCTER, A. W., & Bowen, D. M. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13381.x · Cited by 228 · see citing works
Dillon, K. A., Gross‐Isseroff, R., Israeli, M., & Biegon, A. R. (1991) · Brain Research · doi:10.1016/0006-8993(91)90171-q · Cited by 198 · see citing works
Serotonin Receptor Changes in Dementia of the Alzheimer Type
Cross, A. J., Crow, T. J., Ferrier, I. N., Johnson, J. A., Bloom, S. R., & Corsellis, J. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb06081.x · Cited by 195 · see citing works
Whitaker‐Azmitia, P. M., Clarke, C., & Azmitia, E. C. (1993) · Synapse · doi:10.1002/syn.890140303 · Cited by 181 · see citing works
Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes
Saltzman, A. G., Morse, B., Whitman, M. M., Ivanshchenko, Y., Jaye, M., & Felder, S. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)92105-s · Cited by 168 · see citing works
Brain 5-HT1 binding sites in depressed suicides
Cheetham, S. C., Crompton, M. R., Katona, C., & Horton, R. W. (1990) · Psychopharmacology · doi:10.1007/bf02247138 · Cited by 165 · see citing works
Whitaker‐Azmitia, P. M., & Azmitia, E. C. (1989) · Brain Research · doi:10.1016/0006-8993(89)90972-4 · Cited by 141 · see citing works
Ashby, C. R., Edwards, E., & Wang, R. Y. (1994) · Synapse · doi:10.1002/syn.890170306 · Cited by 116 · see citing works
Lowther, S., Paermentier, F. D., Crompton, M. R., Katona, C., & Horton, R. W. (1994) · Brain Research · doi:10.1016/0006-8993(94)90932-6 · Cited by 97 · see citing works
Burnet, P. W. J., Michelson, D., Smith, M. A., Gold, P. W., & Sternberg, E. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)90664-5 · Cited by 94 · see citing works
Self-citationCytoarchitecture of serotonin‐synthesizing neurons in the pontine tegmentum of the human brain
Baker, K. G., Halliday, G. M., Halasz, P., Hornung, J., Geffen, L. B., Cotton, R. G. H., & Törk, I. (1991) · Synapse · doi:10.1002/syn.890070407 · Cited by 90 · see citing works
Expression of Serotonin Transporter Messenger RNA in the Human Brain
Austin, M. C., Bradley, C. C., Mann, J. J., & Blakely, R. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62062362.x · Cited by 85 · see citing works
Gellman, R. L., & Aghajanian, G. K. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90077-9 · Cited by 80 · see citing works
Francis, P. T., Pangalos, M. N., Pearson, R. C. A., Middlemiss, D. N., Stratmann, G. C., & Bowen, D. M. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11149-x · Cited by 78 · see citing works
Morilak, D. A., Somogyi, P., Luján, R., & Ciaranello, R. D. (1994) · Neuropsychopharmacology · doi:10.1038/sj.npp.1380102 · Cited by 68 · see citing works
Burnet, P. W. J., Eastwood, S. L., & Harrison, P. J. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90296-8 · Cited by 62 · see citing works
Self-citationGérard, C., Langlois, X., Gingrich, J. A., Doucet, E., Vergé, D., Kia, H. K., Raisman‐Vozari, R., GOZLAN, H., Mestikawy, S. E., & Hamon, M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90472-3 · Cited by 42 · see citing works
Localization and gene expression of serotonin1A (5HT1A) receptors in human brain postmortem
Marazziti, D., Marracci, S., Palego, L., Rotondò, A., Mazzanti, C. M., Nardi, I., Ladinsky, H., Giraldo, E., Borsini, F., & Cassano, G. B. (1994) · Brain Research · doi:10.1016/s0006-8993(09)90010-5 · Cited by 37 · see citing works
Neuronal localization of 5-HTIA receptor mRNA and protein in rat embryonic brain stem cultures
Hillion, J., Catelon, J., Riad, M., Hamon, M., & Vitry, F. D. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90124-4 · Cited by 37 · see citing works
Ding, D., Tóth, M., Zhou, Y., Parks, C. L., Hoffman, B. J., & Shenk, T. E. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90040-v · Cited by 37 · see citing works
Production and characterization of a specific 5-HT2 receptor antibody
Garlow, S. J., Morilak, D. A., Dean, R. R., Roth, B. L., & Ciaranello, R. D. (1993) · Brain Research · doi:10.1016/0006-8993(93)91121-8 · Cited by 35 · see citing works
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,150 · see citing works
Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762 · see citing works
The neuropathology of schizophrenia
Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677 · see citing works
Self-citationNichols, D. E. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.11.002 · Cited by 1,211 · see citing works
Nichols, D. E., & Nichols, C. D. (2008) · Chemical Reviews · doi:10.1021/cr078224o · Cited by 895 · see citing works
López, J. F., Chalmers, D. T., Little, K. Y., & Watson, S. J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00484-8 · Cited by 700 · see citing works
Jakab, R. L., & Goldman-Rakic, P. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.735 · Cited by 536 · see citing works
Aghajanian, G. K., & Marek, G. J. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00051-8 · Cited by 516 · see citing works
Diverse Actions of Ovarian Steroids in the Serotonin Neural System
Bethea, C. L., Lu, N. Z., Gundlah, C., & Streicher, J. M. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0225 · Cited by 487 · see citing works
Serotonin modulation of cortical neurons and networks
Celada, P., Puig, M. V., & Artigas, F. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00025 · Cited by 462 · see citing works
Neuromodulatory transmitter systems in the cortex and their role in cortical plasticity
Gu, Q. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00026-x · Cited by 518 · see citing works
Rajkowska, G., O'Dwyer, G., Teleki, Z., Stockmeier, C. A., & Miguel-Hidalgo, J. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301234 · Cited by 430 · see citing works
The role of serotonin 5-HT2A receptors in memory and cognition
Zhang, G., & Stackman, R. W. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00225 · Cited by 386 · see citing works
The neuropathology of primary mood disorder
Harrison, P. J. (2002) · Brain · doi:10.1093/brain/awf149 · Cited by 321 · see citing works
Self-citationSerotonin receptors involved in antidepressant effects
Artigas, F. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.09.006 · Cited by 311 · see citing works
López-Figueroa, A. L., Norton, C. S., López-Figueroa, M. O., Armellini-Dodel, D., Burke, S., Akil, H., López, J. F., & Watson, S. J. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.09.017 · Cited by 296 · see citing works
Burnet, P. W. J. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00053-x · Cited by 286 · see citing works
Self-citationHall, H., Lundkvist, C., Halldin, C., Farde, L., Pike, V. W., McCarron, J. A., Fletcher, A., Cliffe, I. A., Barf, T. A., Wikström, H., et al. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01131-6 · Cited by 280 · see citing works
Tracer Kinetic Modeling of the 5-HT1AReceptor Ligand [carbonyl-11C]WAY-100635 for PET
Gunn, R. N., Sargent, P. A., Bench, C. J., Rabiner, E. A., Osman, S., Pike, V. W., Hume, S. P., Grasby, P. M., & Lammertsma, A. A. (1998) · NeuroImage · doi:10.1006/nimg.1998.0379 · Cited by 273 · see citing works
Barnes, N. M., Ahern, G. P., Bécamel, C., Bockaert, J., Camilleri, M., Chaumont‐Dubel, S., Claeysen, S., Cunningham, K. A., Fone, K. C. F., Gershon, M. D., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.118.015552 · Cited by 264 · see citing works
Bhagwagar, Z., Rabiner, E. A., Sargent, P. A., Grasby, P. M., & Cowen, P. J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001401 · Cited by 255 · see citing works
PET imaging of 5-HT1Areceptor binding in patients with temporal lobe epilepsy
Toczek, M. T., Carson, R. E., Láng, L., Ma, Y., Spanaki, M. V., Der, M. G., Fazilat, S., Kopylev, L., Herscovitch, P., Eckelman, W. C., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000049930.93113.20 · Cited by 241 · see citing works
Activation of Serotonin Receptors Modulates Synaptic Transmission in Rat Cerebral Cortex
Zhou, F.-M., & Hablitz, J. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.6.2989 · Cited by 238 · see citing works
The Serotonin1A A Receptor: A Representative Member of the Serotonin Receptor Family
Pucadyil, T. J., Kalipatnapu, S., & Chattopadhyay, A. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-3969-3 · Cited by 226 · see citing works
The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity
Bortolozzi, A. A., Díaz-Mataix, L., Scorza, M. C., Celada, P., & Artigas, F. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03485.x · Cited by 224 · see citing works
Bhagwagar, Z., Hinz, R., Taylor, M. J., Fancy, S., Cowen, P. J., & Grasby, P. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1580 · Cited by 214 · see citing works
The 5-HT1A receptor in schizophrenia: a promising target for novel atypical neuroleptics?
Bantick, R. A., Deakin, J. F. W., & Grasby, P. M. (2001) · Journal of Psychopharmacology · doi:10.1177/026988110101500108 · Cited by 214 · see citing works
Hajós, M., Hajós‐Korcsok, É., & Sharp, T. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702510 · Cited by 210 · see citing works
Gobert, A., Rivet, J., Audinot, V., Newman‐Tancredi, A., Cistarelli, L., & Millan, M. J. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00565-4 · Cited by 203 · see citing works
The serotonergic system in Parkinson's disease
Huot, P., Fox, S. H., & Brotchie, J. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.004 · Cited by 195 · see citing works
Receptor mapping: architecture of the human cerebral cortex.
Zilles, K., & Amunts, K. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32832d95db · Cited by 181 · see citing works
Adell, A., & Artigas, F. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.05.001 · Cited by 190 · see citing works
Norton, W. H. J., Folchert, A., & Bally‐Cuif, L. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21831 · Cited by 182 · see citing works
Ovarian steroids and serotonin neural function
Bethea, C. L., Pecins-Thompson, M., Schutzer, W. E., Gundlah, C., & Lu, Z. (1998) · Molecular Neurobiology · doi:10.1007/bf02914268 · Cited by 180 · see citing works
Jakab, R. L., & Goldman, P. S. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000214)417:3 · Cited by 180 · see citing works
Doherty, M. D., & Pickel, V. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02062-x · Cited by 178 · see citing works
Alterations in the cortical serotonergic system in schizophrenia: A postmortem study
Gurevich, E. V., & Joyce, J. N. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00321-1 · Cited by 176 · see citing works
Burnet, P. W. J. (1997) · Neurochemistry International · doi:10.1016/s0197-0186(96)00124-6 · Cited by 174 · see citing works
Self-citationPsychedelics and Other Psychoplastogens for Treating Mental Illness.
Vargas, M. V., Meyer, R., Avanes, A. A., Rus, M., & Olson, D. E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.727117 · Cited by 166 · see citing works
Transmitter receptors and functional anatomy of the cerebral cortex
Zilles, K., Palomero‐Gallagher, N., & Schleicher, A. (2004) · Journal of Anatomy · doi:10.1111/j.0021-8782.2004.00357.x · Cited by 159 · see citing works
5-HT2 Receptor Regulation of Extracellular GABA Levels in the Prefrontal Cortex
Abi‐Saab, W. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00046-3 · Cited by 158 · see citing works
Porter, R. H. P., Eastwood, S. L., & Harrison, P. J. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01404-7 · Cited by 158 · see citing works
Self-citationSartim, A. G., Guimarães, F. S., & Joca, S. R. L. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.01.033 · Cited by 156 · see citing works
Pasqualetti, M., Ori, M., Castagna, M., Marazziti, D., Cassano, G. B., & Nardi, I. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00011-1 · Cited by 154 · see citing works
Pecins-Thompson, M., & Bethea, C. L. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00326-1 · Cited by 148 · see citing works
Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link?
Sierksma, A. S. R., van den Hove, D. L. A., Steinbusch, H. W. M., & Prickaerts, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.021 · Cited by 139 · see citing works
Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse
Bubar, M. J., & Cunningham, K. A. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00916-3 · Cited by 139 · see citing works
Serotonin/dopamine interaction in memory formation
González‐Burgos, I., & Feria‐Velasco, A. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00928-x · Cited by 131 · see citing works
Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction
Cunningham, K. A., & Anastasio, N. C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.030 · Cited by 131 · see citing works
Pehek, E. A., McFarlane, H. G., Maguschak, K. A., Price, B., & Pluto, C. P. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03004-3 · Cited by 131 · see citing works
Drug targets for cognitive enhancement in neuropsychiatric disorders.
Wallace, T. L., Ballard, T. M., Pouzet, B., Riedel, W. J., & Wettstein, J. G. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.03.022 · Cited by 127 · see citing works
Geyer, S., Schleicher, A., & Zilles, K. (1997) · NeuroImage · doi:10.1006/nimg.1997.0271 · Cited by 127 · see citing works
How serotonin receptors regulate morphogenic signalling in neurons
Wirth, A., Holst, K., & Ponimaskin, E. G. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.007 · Cited by 122 · see citing works
Neuromodulatory Role of Serotonin in the Ferret Thalamus
Monckton, J. E., & McCormick, D. A. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00650.2001 · Cited by 121 · see citing works
Borrow, A. P., & Cameron, N. M. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.05.009 · Cited by 120 · see citing works
Steininger, T. L., Gong, H., McGinty, D., & Szymusiak, R. S. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010122)429:4 · Cited by 240 · see citing works
Krolick, K. N., Zhu, Q., & Shi, H. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.07.008 · Cited by 121 · see citing works
Kulikov, A. V., Naumenko, V. S., Voronova, I. P., Tikhonova, M. A., & Popova, N. K. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.06.005 · Cited by 115 · see citing works
de Almeida, J., & Mengod, G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04768.x · Cited by 109 · see citing works
5-HT Receptors and the Development of New Antidepressants
Ślifirski, G., Król, M., & Turło, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169015 · Cited by 111 · see citing works
Lai, M. K. P., Tsang, S. W., Alder, J. T., Keene, J., Hope, T., Esiri, M. M., Francis, P. T., & Chen, C. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2077-2 · Cited by 110 · see citing works
Ainsworth, K., Smith, S. E., Zetterström, T., Pei, Q., Franklin, M., & Sharp, T. (1998) · Psychopharmacology · doi:10.1007/s002130050791 · Cited by 111 · see citing works
Genetic variation of the 5-HT2A receptor and response to clozapine
Nöthen, M. M., Rietschel, M., Erdmann, J., Oberländer, H., Möller, H., Naber, D., Propping, P., Burnet, P. W. J., & Harrison, P. J. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92756-5 · Cited by 111 · see citing works
Self-citationPresynaptic control of serotonin on striatal dopamine function
Navailles, S., & Deurwaerdère, P. D. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2029-y · Cited by 109 · see citing works
Cornea-Hébert, V., Watkins, K. C., Roth, B. L., Kroeze, W. K., Gaudreau, P., Leclerc, N. M., & Descarries, L. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00146-x · Cited by 106 · see citing works
Serotonin Receptor 2A Gene Polymorphism (–1438A/G) and Short-Term Treatment Response to Citalopram
Choi, M.-J., Kang, R.-H., Ham, B., Jeong, H.-Y., & Lee, M.-S. (2005) · Neuropsychobiology · doi:10.1159/000087847 · Cited by 106 · see citing works
[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS
Turner, M. R. (2005) · Brain · doi:10.1093/brain/awh428 · Cited by 105 · see citing works
Vinkers, C. H., van Bogaert, M. J. V., Klanker, M., Korte, S. M., Oosting, R. S., Hanania, T., Hopkins, S. C., Olivier, B., & Groenink, L. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.097 · Cited by 104 · see citing works
Neurochemical basis for symptomatic treatment of Alzheimer's disease
Francis, P. T., Ramírez, M. J., & Lai, M. K. P. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.02.010 · Cited by 104 · see citing works
Neuron density and serotonin receptor binding in prefrontal cortex in suicide
Underwood, M. D., Kassir, S. A., Bakalian, M. J., Galfalvy, H., Mann, J. J., & Arango, V. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000691 · Cited by 100 · see citing works
Gobert, A., Rivet, J., Cistarelli, L., Melon, C., & Millan, M. J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00211-0 · Cited by 103 · see citing works
Frechilla, D., Cobreros, A., Saldise, L., Moratalla, R., Insausti, R., Luquín, M. R., & R�o, J. D. (2001) · Synapse · doi:10.1002/1098-2396(20010315)39:4 · Cited by 103 · see citing works
Cusin, C., Serretti, A., Zanardi, R., Lattuada, E., Rossini, D., Lilli, R., Lorenzi, C., & Smeraldi, E. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145701002711 · Cited by 101 · see citing works
Serotonin and motherhood: From molecules to mood
Pawluski, J. L., Li, M., & Lonstein, J. S. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.03.001 · Cited by 98 · see citing works
Watakabe, A., Komatsu, Y., Sadakane, O., Shimegi, S., Takahata, T., Higo, N., Tochitani, S., Hashikawa, T., Naito, T., Osaki, H., et al. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn219 · Cited by 93 · see citing works
Fine-tuning serotonin2c receptor function in the brain: Molecular and functional implications
Berg, K. A., Clarke, W. P., Cunningham, K. A., & Spampinato, U. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.014 · Cited by 91 · see citing works
Modulatory effects of cannabinoids on brain neurotransmission
Cohen, K., Weizman, A., & Weinstein, A. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14407 · Cited by 92 · see citing works
Goodfellow, N. M., Benekareddy, M., Vaidya, V. A., & Lambe, E. K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1960-09.2009 · Cited by 90 · see citing works
Anastasio, N. C., Stutz, S. J., Fink, L. H. L., Swinford-Jackson, S. E., Sears, R. M., Dileone, R., Rice, K. C., Moeller, F. G., & Cunningham, K. A. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00094 · Cited by 88 · see citing works
Serotonin Induces EPSCs Preferentially in Layer V Pyramidal Neurons of the Frontal Cortex in the Rat
Lambe, E. K. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.974 · Cited by 86 · see citing works
Enteroendocrine cell regulation of the gut-brain axis
Barton, J. R., Londregan, A., Alexander, T. D., Entezari, A. A., Covarrubias, M., & Waldman, S. A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1272955 · Cited by 90 · see citing works
Fabbri, C., Hosák, L., Mößner, R., Giegling, I., Mandelli, L., Bellivier, F., Claes, S. J., Collier, D. A., Corrales, A., DeLisi, L. E., et al. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1208843 · Cited by 81 · see citing works
Lambe, E. K., Fillman, S. G., Webster, M. J., & Weickert, C. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022799 · Cited by 81 · see citing works
[3H]MDL100,907 labels 5-HT2A serotonin receptors selectively in primate brain
López‐Giménez, J. F., Vilaró, M. T., Palacios, J. M., & Mengod, G. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00102-6 · Cited by 80 · see citing works
Fedi, M., Reutens, D. C., Andermann, F., Okazawa, H., Boling, W., White, C. L., Dubeau, F., Nakai, A., Gross, D. W., Andermann, E., et al. (2003) · Epilepsy Research · doi:10.1016/s0920-1211(02)00216-4 · Cited by 80 · see citing works
Zimmer, L., Mauger, G., Bars, D. L., Bonmarchand, G., Luxen, A., & Pujol, J. F. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00696.x · Cited by 79 · see citing works
Expression of serotonin 5‐HT 2A receptors in the human cerebellum and alterations in schizophrenia
Eastwood, S. L., Burnet, P. W. J., Gittins, R., Baker, K., & Harrison, P. J. (2001) · Synapse · doi:10.1002/syn.1106 · Cited by 78 · see citing works
Self-citationBurnet, P. W. J., Chen, C., McGowan, S., Franklin, M., & Harrison, P. J. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00062-0 · Cited by 78 · see citing works
Self-citationSEROTONERGIC MECHANISMS IN AMYOTROPHIC LATERAL SCLEROSIS
Sandyk, R. (2006) · International Journal of Neuroscience · doi:10.1080/00207450600754087 · Cited by 78 · see citing works
Distribution of the 5-HT5A serotonin receptor mRNA in the human brain
Pasqualetti, M., Ori, M., Nardi, I., Castagna, M., Cassano, G. B., & Marazziti, D. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00003-5 · Cited by 74 · see citing works
Matthews, P., & Harrison, P. J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.10.043 · Cited by 73 · see citing works
Self-citationRewiring of the Serotonin System in Major Depression
Vahid-Ansari, F., & Albert, P. R. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.802581 · Cited by 73 · see citing works
Dieudonné, S. (2001) · The Neuroscientist · doi:10.1177/107385840100700306 · Cited by 71 · see citing works
Development and Characterization of Monoclonal Antibodies Specific to the Serotonin 5-HT 2A Receptor
Wu, C., Yoder, E. J., Shih, J. C., Chen, K., Dias, P., Shi, L., Ji, X.-D., Wei, J., Conner, J. M., Kumar, S., et al. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804600704 · Cited by 69 · see citing works
Effects of 5-HT on memory and the hippocampus: model and data.
Meeter, M., Talamini, L., Schmitt, J. A. J., & Riedel, W. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300869 · Cited by 68 · see citing works
Architecture, Connectivity, and Transmitter Receptors of Human Extrastriate Visual Cortex
Zilles, K., & Clarke, S. (1997) · Cerebral cortex · doi:10.1007/978-1-4757-9625-4_15 · Cited by 66 · see citing works
Brain Region-Specific Monoaminergic Correlates of Neuropsychiatric Symptoms in Alzheimer's Disease
Vermeiren, Y., Dam, D. V., Aerts, T., Engelborghs, S., & Deyn, P. P. D. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140309 · Cited by 65 · see citing works
Nichols, D. E., Frescas, S. P., Chemel, B. R., Rehder, K. S., Zhong, D., & Lewin, A. H. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.04.050 · Cited by 65 · see citing works
Psychedelic‐inspired approaches for treating neurodegenerative disorders
Saeger, H. N., & Olson, D. E. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15544 · Cited by 65 · see citing works
Layunta, E., Buey, B., Mesonero, J. E., & Latorre, E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.748254 · Cited by 67 · see citing works
- Authors
- Burnet, P. W. J., Eastwood, S. L., Lacey, K., & Harrison, P. J.
- Affiliations
- Warneford Hospital (GB)
- Corresponding author
- Burnet, P.W.J.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 676
- Issue
- 1
- Pages
- 157-168
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2058711144
- Cited by
- 283
- References
- 39
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 11 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 9 · 2013: 5 · 2012: 7
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- 5-HT1A receptor, 5-HT2A receptor, serotonin receptors, receptor mRNA distribution, human brain, hippocampus, neocortex, raphe nuclei, pyramidal neurons, laminae, dentate gyrus granule cells, postmortem brain
- MeSH terms
- Aged, Autoradiography, Basal Ganglia, Brain, Brain Stem, Cerebellum, Cerebral Cortex, Female, Hippocampus, Humans, Male, Receptors, Serotonin, RNA, Messenger, Tissue Distribution, In Situ Hybridization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review