Enriched Expression of Serotonin 1B and 2A Receptor Genes in Macaque Visual Cortex and their Bidirectional Modulatory Effects on Neuronal Responses

Watakabe, Akiya; Komatsu, Yusuke; Sadakane, Osamu; Shimegi, Satoshi; Takahata, Toru; Higo, Noriyuki; Tochitani, Shiro; Hashikawa, Tsutomu; Naito, Tomoyuki; Osaki, Hironobu; Sakamoto, Hiroshi; Okamoto, Masahiro; Ishikawa, Ayako; Hara, Shin-ichiro; Akasaki, Takafumi; Sato, Hiromichi; Yamamori, Tetsuo

doi:10.1093/cercor/bhn219

Cited by 93Neurotransmitter Receptor Influence on BehaviorVisual perception and processing mechanismsNeuroscience and Neuropharmacology Research

Enriched Expression of Serotonin 1B and 2A Receptor Genes in Macaque Visual Cortex and their Bidirectional Modulatory Effects on Neuronal Responses

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Watakabe, Akiya, Komatsu, Yusuke, Sadakane, Osamu, Shimegi, Satoshi, Takahata, Toru, Higo, Noriyuki, Tochitani, Shiro, Hashikawa, Tsutomu +9 more·2009·Cerebral Cortex

DOI 10.1093/cercor/bhn219PMC PMC2705701

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Abstract

To study the molecular mechanism how cortical areas are specialized in adult primates, we searched for area-specific genes in macaque monkeys and found striking enrichment of serotonin (5-hydroxytryptamine, 5-HT) 1B receptor mRNA, and to a lesser extent, of 5-HT2A receptor mRNA, in the primary visual area (V1). In situ hybridization analyses revealed that both mRNA species were highly concentrated in the geniculorecipient layers IVA and IVC, where they were coexpressed in the same neurons. Monocular inactivation by tetrodotoxin injection resulted in a strong and rapid (<3 h) downregulation of these mRNAs, suggesting the retinal activity dependency of their expression. Consistent with the high expression level in V1, clear modulatory effects of 5-HT1B and 5-HT2A receptor agonists on the responses of V1 neurons were observed in in vivo electrophysiological experiments. The modulatory effect of the 5-HT1B agonist was dependent on the firing rate of the recorded neurons: The effect tended to be facilitative for neurons with a high firing rate, and suppressive for those with a low firing rate. The 5-HT2A agonist showed opposite effects. These results suggest that this serotonergic system controls the visual response in V1 for optimization of information processing toward the incoming visual inputs.

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Cortical pyramidal neurons show heterogeneous expression of serotonin receptors and therefore may exhibit varied responses to activation of serotonergic afferents.
“However, cortical pyramidal neurons show heterogeneous expression of serotonin receptors and therefore may exhibit varied responses to activation of serotonergic afferents201.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [201]

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Distributed hierarchical processing in the primate cerebral cortex
Felleman, D. J., & Van Essen, D. C. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.1 · Cited by 7,783 · see citing works
Preface: Cerebral Cortex Has Come of Age
Goldman, P. S., & RAKIC, P. T. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.1-a · Cited by 3,412 · see citing works
A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,150 · see citing works
Ferrier lecture. Functional architecture of macaque monkey visual cortex
Hubel, D. H., & Wiesel, T. N. (1977) · Proceedings of the Royal Society of London. Series B. Biological Sciences · doi:10.1098/rspb.1977.0085 · Cited by 2,608 · see citing works
Molecular, pharmacological and functional diversity of 5-HT receptors
Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,869 · see citing works
Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior
González-Maeso, J., Weisstaub, N. V., Zhou, M., Chan, P., Ivic, L., Ang, R., Lira, A., Bradley-Moore, M., Ge, Y., Zhou, Q., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.008 · Cited by 925 · see citing works
Dorsal raphe neurons: depression of firing during sleep in cats
McGinty, D., & Harper, R. M. (1976) · Brain Research · doi:10.1016/0006-8993(76)90480-7 · Cited by 900 · see citing works
Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons
Takamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2000) · Nature · doi:10.1038/35025070 · Cited by 862 · see citing works
Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter
Bellocchio, E. E., Reimer, R. J., Fremeau, R. T., & Edwards, R. H. (2000) · Science · doi:10.1126/science.289.5481.957 · Cited by 795 · see citing works
5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex
Araneda, R. C., & Andrade, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90128-b · Cited by 621 · see citing works
Classifying simple and complex cells on the basis of response modulation
SKOTTUN, B. C., Valois, R. L. D., Grosof, D. H., Movshon, J. A., Albrecht, D. G., & Bonds, A. B. (1991) · Vision Research · doi:10.1016/0042-6989(91)90033-2 · Cited by 608 · see citing works
LOCAL CIRCUITS IN PRIMARY VISUAL CORTEX OF THE MACAQUE MONKEY
Callaway, E. M. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.47 · Cited by 603 · see citing works
Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain
Riad, M., Garcia, S., Watkins, K. C., Jodoin, N., Doucet, �., Langlois, X., Mestikawy, S. E., Hamon, M., & Descarries, L. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000207)417:2 · Cited by 502 · see citing works
Control of Dorsal Raphe Serotonergic Neurons by the Medial Prefrontal Cortex: Involvement of Serotonin-1A, GABA<sub>A</sub>, and Glutamate Receptors
Celada, P., Puig, M. V., Casanovas, J. M., Guillazo, G., & Artigas, F. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09917.2001 · Cited by 497 · see citing works
Synaptic organization of serotonin‐immunoreactive fibers in primary visual cortex of the macaque monkey
de Lima, A. D., Bloom, F. E., & Morrison, J. H. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902740211 · Cited by 459 · see citing works
THE CIRCUITRY OF V1 AND V2: Integration of Color, Form, and Motion
Sincich, L. C., & Horton, J. C. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135731 · Cited by 433 · see citing works
The emergence and evolution of mammalian neocortex
Glenn Northcutt, R., & Kaas, J. H. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93932-n · Cited by 378 · see citing works
A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?
Knapska, E., & Kaczmarek, L. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.007 · Cited by 371 · see citing works
The mouse 5-hydroxytryptamine 1B receptor is localized predominantly on axon terminals
Boschert, U., Amara, D. A., Ségu, L., & Hen, R. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90164-3 · Cited by 352 · see citing works
Localization of 5-HT1B, 5-HT1Dα, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain
Bruinvels, A. T., Landwehrmeyer, G. B., Gustafson, E. L., Durkin, M. M., Mengod, G., Branchek, T. A., Hoyer, D., & Palacios, J. M. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90067-1 · Cited by 350 · see citing works
Anatomical Organization Of Macaque Monkey Striate Visual Cortex
Lund, J. S. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.001345 · Cited by 336 · see citing works
Serotonin receptors: from protein to physiological function and behavior
Sari, Y. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.008 · Cited by 332 · see citing works
Molecular basis of plasticity in the visual cortex
Berardi, N., Pizzorusso, T., Ratto, G. M., & Maffei, L. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00168-1 · Cited by 284 · see citing works
The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain
Burnet, P. W. J., Eastwood, S. L., Lacey, K., & Harrison, P. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00104-x · Cited by 283 · see citing works
Subregional organization of preoptic area /anterior hypothalamic projections to arousal-related monoaminergic cell groups
Steininger, T. L., Gong, H., McGinty, D., & Szymusiak, R. S. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010122)429:4 · Cited by 240 · see citing works
Activation of Serotonin Receptors Modulates Synaptic Transmission in Rat Cerebral Cortex
Zhou, F.-M., & Hablitz, J. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.6.2989 · Cited by 238 · see citing works
Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex
Miner, L. A. H., Backstrom, J. R., Sanders-Bush, E., & Sesack, S. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00580-8 · Cited by 216 · see citing works
Noradrenergic and serotonergic fibers innervate complementary layers in monkey primary visual cortex: an immunohistochemical study.
Morrison, J. H., Foote, S. L., Molliver, M. E., Bloom, F. E., & Lidov, H. G. W. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.7.2401 · Cited by 211 · see citing works
Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex
Tanaka, E., & NORTH, R. A. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.5.1749 · Cited by 187 · see citing works
Characterization of the human 5-hydroxytryptamine1B receptor.
Jin, H., Oksenberg, D., Ashkenazi, A., Peroutka, S. J., Duncan, A., Rozmahel, R. F., Yang, Y., Mengod, G., Palacios, J. M., & O’Dowd, B. F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42612-9 · Cited by 177 · see citing works
LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex.
Marek, G. J., & Aghajanian, G. K. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20792-3 · Cited by 152 · see citing works
Serotoninergic Neurons and 5-HT Receptors in the CNS
(2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60921-3 · Cited by 151 · see citing works
Differential effects of monocular deprivation on glutamic acid decarboxylase and type II calcium-calmodulin-dependent protein kinase gene expression in the adult monkey visual cortex [published erratum appears in J Neurosci 1991 May;11(5):following Table of Contents]
Benson, D. L., Isackson, P. J., Gall, C. M., & Jones, E. G. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-01-00031.1991 · Cited by 149 · see citing works
5-HT1BReceptor–Mediated Presynaptic Inhibition of Retinal Input to the Suprachiasmatic Nucleus
Pickard, G. E., Smith, B. N., Belenky, M. A., Rea, M. A., Dudek, F. E., & Sollars, P. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04034.1999 · Cited by 145 · see citing works
Relationship between excitation and inhibition underlying size tuning and contextual response modulation in the cat primary visual cortex
Ozeki, H., Sadakane, O., Akasaki, T., Naito, T., Shimegi, S., & Sato, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3852-03.2004 · Cited by 136 · see citing works
Self-citation
The organization of serotonergic projections to cerebral cortex in primates: Retrograde transport studies
Wilson, M. A., & Molliver, M. E. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90077-2 · Cited by 133 · see citing works
Excitatory responses to serotonin (5‐HT) in neurons of the rat piriform cortex: Evidence for mediation by 5‐HT1C receptors in pyramidal cells and 5‐HT2 receptors in interneurons
Sheldon, P. W., & Aghajanian, G. K. (1991) · Synapse · doi:10.1002/syn.890090307 · Cited by 131 · see citing works
Comparative Analysis of Layer-Specific Genes in Mammalian Neocortex
Watakabe, A., Ichinohe, N., Ohsawa, S., Hashikawa, T., Komatsu, Y., Rockland, K. S., & Yamamori, T. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl102 · Cited by 131 · see citing works
Self-citation
Detailed mapping of serotonin 5-HT1B and 5-HT1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function
Bonaventure, P., Voorn, P., Luyten, W. H. M. L., Jurzak, M., Schotte, A., & Leysen, J. E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00302-3 · Cited by 124 · see citing works
Activity-Dependent Presynaptic Effect of Serotonin 1B Receptors on the Somatosensory Thalamocortical Transmission in Neonatal Mice
Laurent, A., Goaillard, J., Cases, O., Lebrand, C., Gaspar, P., & Ropert, N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00886.2002 · Cited by 121 · see citing works
Mechanisms underlying orientation selectivity of neurons in the primary visual cortex of the macaque.
Sato, H., Katsuyama, N., Tamura, H., Hata, Y., & Tsumoto, T. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021530 · Cited by 112 · see citing works
Self-citation
The Role of Kv1.2-Containing Potassium Channels in Serotonin-Induced Glutamate Release from Thalamocortical Terminals in Rat Frontal Cortex
Lambe, E. K., & Aghajanian, G. K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09955.2001 · Cited by 112 · see citing works
Similarity and Diversity in Visual Cortex: Is There a Unifying Theory of Cortical Computation?
Hooser, S. D. V. (2007) · The Neuroscientist · doi:10.1177/1073858407306597 · Cited by 108 · see citing works
Nongeniculate afferents to striate cortex in macaques
Doty, R. W. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902180204 · Cited by 105 · see citing works
Quantitative autoradiography of major neurotransmitter receptors in the monkey striate and extrastriate cortex
RAKIC, P. T., Goldman-Rakic, P. S., & Gallager, D. W. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-10-03670.1988 · Cited by 105 · see citing works
Neuronal activity in primate visual cortex assessed by immunostaining for the transcription factor Zif268
Chaudhuri, A., Matsubara, J. A., & Cynader, M. S. (1995) · Visual Neuroscience · doi:10.1017/s095252380000729x · Cited by 101 · see citing works
Lamina-specific expression and activity-dependent regulation of seven GABAA receptor subunit mRNAs in monkey visual cortex
Huntsman, M. M., Isackson, P. J., & Jones, E. G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02236.1994 · Cited by 100 · see citing works
Local Connections to Specific Types of Layer 6 Neurons in the Rat Visual Cortex
Zarrinpar, A., & Callaway, E. M. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00974.2005 · Cited by 90 · see citing works
Maturation of monoamine neurotransmitters and receptors in cat occipital cortex during postnatal critical period
JONSSON, G., & Kasamatsu, T. (1983) · Experimental Brain Research · doi:10.1007/bf00239212 · Cited by 84 · see citing works
Discharge modulation of rat dorsal raphe neurons during sleep and waking: effects of preoptic/basal forebrain warming
Guzmán-Marı́n, R., Alam, M. N., Szymusiak, R. S., Drucker-Colı́n, R., Gong, H., & McGinty, D. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02561-0 · Cited by 76 · see citing works
Suppressive effects of receptive field surround on neuronal activity in the cat primary visual cortex
Akasaki, T., Sato, H., Yoshimura, Y., et al. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00038-x · Cited by 75 · see citing works
Self-citation
The occ1 gene is preferentially expressed in the primary visual cortex in an activity‐dependent manner: a pattern of gene expression related to the cytoarchitectonic area in adult macaque neocortex
Tochitani, S., Liang, F., Watakabe, A., et al. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01390.x · Cited by 74 · see citing works
Self-citation
Modulation of retinotectal transmission by presynaptic 5-HT1B receptors in the superior colliculus of the adult hamster
MOONEY, R. D., Shi, M. Y., & Rhoades, R. W. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.1.3 · Cited by 73 · see citing works
Postnatal development of laminar innervation patterns by monoaminergic fibers in monkey (Macaca fascicularis) primary visual cortex
Foote, S. L., & Morrison, J. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02667.1984 · Cited by 70 · see citing works
The organization of indoleamine neurons in the brain of the rhesus monkey (Macaca mulatta)
Schofield, S. P. M., & Everitt, B. J. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901970302 · Cited by 59 · see citing works
The role of afferent activity in the maintenance of primate neocortical function
Jones, E. G. (1990) · Journal of Experimental Biology · doi:10.1242/jeb.153.1.155 · Cited by 57 · see citing works
Differential addressing of 5-HT1A and 5-HT1B receptors in epithelial cells and neurons
Ghavami, A., Stark, K. L., Jareb, M., Ramboz, S., Ségu, L., & Hen, R. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.6.967 · Cited by 57 · see citing works
Regional expression of 5-HT1Breceptor mRNA in the human brain
Varnäs, K., Hurd, Y. L., & Hall, H. (2005) · Synapse · doi:10.1002/syn.20128 · Cited by 54 · see citing works
Retinol-binding Protein Gene is Highly Expressed in Higher-order Association Areas of the Primate Neocortex
Komatsu, Y. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh112 · Cited by 54 · see citing works
Self-citation
Cell- and Lamina-Specific Expression and Activity-Dependent Regulation of Type II Calcium/Calmodulin-Dependent Protein Kinase Isoforms in Monkey Visual Cortex
Tighilet, B., Hashikawa, T., & Jones, E. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02129.1998 · Cited by 52 · see citing works
Self-citation
Differential localization of two glutamic acid decarboxylases (GAD65 and GAD67) in adult monkey visual cortex
Hendrickson, A. E., Tillakaratne, N. J. K., Mehra, R. D., Esclapez, M., Erickson, A., Vician, L. J., & Tobin, A. J. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903430407 · Cited by 52 · see citing works
Neocortical areas, layers, connections, and gene expression
Yamamori, T., & Rockland, K. S. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.02.006 · Cited by 47 · see citing works
Self-citation
Monoamine distribution in primate brain—IV. Indoleamine-containing perikarya in the brain stem of Macaca arctoides
Sladek, J. R., Garver, D., & Cummings, J. P. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90281-0 · Cited by 41 · see citing works
Enhancement of dorsal raphe discharge by medial pontine reticular formation stimulation depends on behavioral state
Lydic, R., McCarley, R. W., & Hobson, J. A. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90106-4 · Cited by 40 · see citing works
Frequency-Dependent Modulation of Retinogeniculate Transmission by Serotonin
Seeburg, D. P., Liu, X., & Chen, C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3749-04.2004 · Cited by 33 · see citing works
Restriction landmark cDNA scanning (RLCS): a novel cDNA display system using two-dimensional gel electrophoresis
Suzuki, H. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.2.289 · Cited by 33 · see citing works
Activity-dependent Expression of occ1 in Excitatory Neurons Is a Characteristic Feature of the Primate Visual Cortex
Takahata, T., Komatsu, Y., Watakabe, A., Hashikawa, T., Tochitani, S., & Yamamori, T. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj034 · Cited by 32 · see citing works
Self-citation
Nuclear respiratory factor-2 subunit protein: Correlation with cytochrome oxydase and regulation by functional activity in the monkey primary visual cortex
Nie, F., & Wong‐Riley, M. T. T. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990215)404:3 · Cited by 27 · see citing works
Growth/differentiation factor 7 is preferentially expressed in the primary motor area of the monkey neocortex
Watakabe, A., Fujita, H., Hayashi, M., & Yamamori, T. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00177.x · Cited by 21 · see citing works
Self-citation
Large‐scale identification and characterization of genes with asymmetric expression patterns in the developing chick retina
Shintani, T., Kato, A., Yuasa‐Kawada, J., et al. (2004) · Journal of Neurobiology · doi:10.1002/neu.10338 · Cited by 20 · see citing works
Layer-specific differential regulation of transcription factors Zif268 and jun-D in visual cortex V1 and V2 of macaque monkeys
Okuno, H., Kanou, S., Tokuyama, W., et al. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00221-2 · Cited by 16 · see citing works
Identification and localization of 5-hydroxytryptamine receptor sites in macaque visual cortex
Parkinson, D., Coscia, E. M., & Daw, N. W. (1989) · Visual Neuroscience · doi:10.1017/s0952523800012402 · Cited by 7 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

Riad M Garcia S Watkins KC Jodoin N Doucet E Langlois X el Mestikawy S Hamon M Descarries L Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain J Comp Neurol. 2000 417 181 194 10660896
Wong-Riley MT Peters A Rockland KS Primate visual cortex: dynamic metabolic organization and plasticity revealed by cytochrome oxidase Cerebral cortex 1994 New York Plenum Press 141 200

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Serotonin (5HT)1A receptor and its second messenger pathways, and the neuroprotective potential of specific 5-HT1A receptor agonists
Luiten, P. G. M., & Mulder, J. (2000)
[Activation and blocking of 5-HT1A receptors influence on the immune response in CBA mice].
Idova, G. V., Cheĭdo, M. A., & Sm, D. (2005) · PubMed · Cited by 2 · see citing works

Authors: Watakabe, A., Komatsu, Y., Sadakane, O., Shimegi, S., Takahata, T., Higo, N., Tochitani, S., Hashikawa, T., Naito, T., Osaki, H., Sakamoto, H., Okamoto, M., Ishikawa, A., Hara, S.-I., Akasaki, T., Sato, H., & Yamamori, T.
Affiliations: National Institute for Basic Biology (JP)
The University of Osaka (JP)
National Institute of Advanced Industrial Science and Technology (JP)
RIKEN Center for Brain Science (JP)
Corresponding author: Yamamori, Tetsuo
ORCID: Watakabe, Akiya
Shimegi, Satoshi
Takahata, Toru
Higo, Noriyuki
Tochitani, Shiro
Osaki, Hironobu
Okamoto, Masahiro
Ishikawa, Ayako
Sato, Hiromichi
Yamamori, Tetsuo
Venue: Cerebral Cortex
Publisher: Oxford University Press (OUP)
Published: 2008-12-04
Volume: 19
Issue: 8
Pages: 1915-1928
ISSN: 1047-3211 (ISSN-L)
1460-2199
DOI: 10.1093/cercor/bhn219
PMC: PMC2705701
OpenAlex: W2134498737
Cited by: 93
References: 72
Citations by year: 2026: 7 · 2025: 4 · 2024: 11 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 10 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 10 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 4
FWCI: 2.02
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Cerebral Cortex (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (19530656)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: 5-HT1B receptor, 5-HT2A receptor, visual processing, cortical specialization
MeSH terms: Action Potentials, Animals, Chlorocebus aethiops, Electrophysiology, Macaca, Neurons, Photic Stimulation, Visual Cortex, Gene Expression, Serotonin Receptor Agonists, In Situ Hybridization, Reverse Transcriptase Polymerase Chain Reaction, Receptor, Serotonin, 5-HT1B, Receptor, Serotonin, 5-HT2A

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Enriched Expression of Serotonin 1B and 2A Receptor Genes in Macaque Visual Cortex and their Bidirectional Modulatory Effects on Neuronal Responses

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