Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock
Abstract
Brain interleukin-1 (IL-1) plays a key role in mediating the neural, endocrine, and behavioral consequences of injury and infection. Recent evidence indicates that brain IL-1 may also be important in producing endocrine and neurochemical responses to stressors. The present experiment sought to determine whether intracerebroventricular (i.c.v.) administration of an interleukin-1 receptor antagonist (IL-1ra) would block behavioral effects of a stressor. I.c.v. application of hrIL-1ra before inescapable shock blocked the subsequent interference with escape learning and enhancement of fear conditioning normally produced by this treatment.
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Learned helplessness induced by inescapable shocks is inhibited in mice pretreated with IL-1ra.
“The learned helplessness that is induced by inescapable shocks is inhibited in mice that were pretreated with IL-1ra[61].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [61]
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- Authors
- Maier, S. F., & Watkins, L. R.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Maier, Steven F.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 695
- Issue
- 2
- Pages
- 279-282
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2058978987
- Cited by
- 178
- References
- 28
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 11
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh045045-12)
- National Institute of Mental Health (MH-00314, MH 50479, MH-45045)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- interleukin-1 receptor antagonist, interleukin-1, inescapable shock, fear conditioning, escape learning, stress response, intracerebroventricular administration
- MeSH terms
- Animals, Conditioning, Psychological, Electroshock, Escape Reaction, Fear, Helplessness, Learned, Injections, Intraventricular, Interleukin-1, Male, Recombinant Proteins, Restraint, Physical, Stress, Psychological, Rats, Sprague-Dawley, Receptors, Interleukin-1, Rats
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