Cited by 178Stress Responses and CortisolMemory and Neural MechanismsNeuroinflammation and Neurodegeneration Mechanisms

Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock

Maier, Steven F., Watkins, Linda R.·1995·Brain Research

Abstract

Brain interleukin-1 (IL-1) plays a key role in mediating the neural, endocrine, and behavioral consequences of injury and infection. Recent evidence indicates that brain IL-1 may also be important in producing endocrine and neurochemical responses to stressors. The present experiment sought to determine whether intracerebroventricular (i.c.v.) administration of an interleukin-1 receptor antagonist (IL-1ra) would block behavioral effects of a stressor. I.c.v. application of hrIL-1ra before inescapable shock blocked the subsequent interference with escape learning and enhancement of fear conditioning normally produced by this treatment.

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Crossref · 10.1016/0006-8993(95)00930-o

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Authors
Maier, S. F., & Watkins, L. R.
Affiliations
University of Colorado Boulder (US)
Corresponding author
Maier, Steven F.
Venue
Brain Research
Publisher
Elsevier BV
Published
1995-10
Volume
695
Issue
2
Pages
279-282
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2058978987
Cited by
178
References
28
Citations by year
2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 11
FWCI
2.67
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh045045-12)
  • National Institute of Mental Health (MH-00314, MH 50479, MH-45045)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
interleukin-1 receptor antagonist, interleukin-1, inescapable shock, fear conditioning, escape learning, stress response, intracerebroventricular administration
MeSH terms
Animals, Conditioning, Psychological, Electroshock, Escape Reaction, Fear, Helplessness, Learned, Injections, Intraventricular, Interleukin-1, Male, Recombinant Proteins, Restraint, Physical, Stress, Psychological, Rats, Sprague-Dawley, Receptors, Interleukin-1, Rats

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