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Cited by 36

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Reduced binding of oxytocin in the rat brain during aging

Arsenijevic, Yvan, Dreifuss, Jean Jacques, Vallet, Philippe, Marguerat, Anouk, Tribollet, Eliane·1995·Brain Research
DOI 10.1016/0006-8993(95)01020-v
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Abstract

Central oxytocin (OT) receptors were labelled in 3-month-old and 20-month-old rats with an iodinated OT antagonist. Comparison of the autoradiograms by quantitative image analysis revealed in the old animals a significant reduction of binding in three regions; the number of labelled OT receptors was decreased by 90% in the head of the caudate putamen, by 68% in the olfactory tubercle, and by 41% in the ventromedial hypothalamic nucleus. Previous studies had shown that the expression of OT receptors in the olfactory tubercle and in the ventromedial hypothalamic nucleus was dependent upon gonadal steroids. Therefore we hypothesize that the reduced number of OT receptors in the latter two structures of aged rats was the consequence of the 4-fold decrease of plasma testosterone that we found in this age. Another mechanism may be responsible for the marked reduction of OT receptors in the caudate putamen.

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Research works printed but not linked: 13

  1. Algeri, 1977, Dihydropteridine reductase and tyrosine hydroxylase activities in rat brain during development and senescence: a comparative study, Brain Res., 132, 569, 10.1016/0006-8993(77)90206-2 · DOI
  2. Argiolas, 1988, Yawning and penile erection: central dopamine-oxytocin-adrenocorticotropin connection, Ann. NY Acad. Sci., 525, 330, 10.1111/j.1749-6632.1988.tb38617.x · DOI
  3. Bugiani, 1978, Nerve cell loss with aging in the putamen, Eur. Neurol., 17, 286, 10.1159/000114960 · DOI
  4. Elands, 1988, 125I-Labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr(NH2)9]OVT: a selective oxytocin receptor ligand, Eur. J. Pharmacol., 147, 197, 10.1016/0014-2999(88)90778-9 · DOI · Paper page
  5. Finch, 1973, Catecholamine metabolism in the brains of ageing male mice, Brain Res., 52, 261, 10.1016/0006-8993(73)90663-X · DOI
  6. Fliers, 1985, Changes with aging in the vasopressin and oxytocin innervation of the rat brain, Brain Res., 348, 1, 10.1016/0006-8993(85)90351-8 · DOI
  7. Goudsmit, 1988, Testosterone supplementation restores vasopressin innervation in the senescent rat brain, Brain Res., 473, 306, 10.1016/0006-8993(88)90859-1 · DOI
  8. Moos, 1988, Characteristics of early- and late-recruited oxytocin bursting cells at the beginning of suckling in rats, J. Physiol., 399, 1, 10.1113/jphysiol.1988.sp017064 · DOI
  9. Pfaff, 1973, Atlas of estradiol-concentrating cells in the central nervous system of the female rat, J. Comp. Neurol., 151, 121, 10.1002/cne.901510204 · DOI
  10. Sizonenko, 1975, Hormonal changes in puberty. III. Correlation of plasma dehydroepiandrosterone, testosterone, FSH and LH with stages of puberty and bone age in normal boys and girls in patients with Addison's disease of hypogonadism or with premature or late adrenarche, J. Clin. Endocrinol. Metab., 41, 894, 10.1210/jcem-41-5-894 · DOI
  11. Tribollet, 1992, Vasopressin and oxytocin receptors in the rat brain, Vol. 11, 105
  12. Wise, 1984, Age-related changes in cytoplasmic estradiol receptor concentrations in microdissected brain nuclei: correlations with changes in steroid-induced sexual behavior, Brain Res., 321, 119, 10.1016/0006-8993(84)90687-5 · DOI
  13. Zoli, 1990, Aspects of neural plasticity in the central nervous system. IV. Chemical anatomical studies on the aging brain, Neurochem. Int., 16, 437, 10.1016/0197-0186(90)90005-E · DOI

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Metadata

Authors
Arsenijevic, Y., Dreifuss, J. J., Vallet, P., Marguerat, A., & Tribollet, E.
Venue
Brain Research
Publisher
Elsevier BV
Published
1995-11
Volume
698
Issue
1-2
Pages
275-279
ISSN
0006-8993
DOI
10.1016/0006-8993(95)01020-v
Cited by
36
References
6
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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