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Cited by 183Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats

Lukas, M., Bredewold, R., Neumann, I.D., Veenema, A.H.·2010·Neuropharmacology
DOI 10.1016/j.neuropharm.2009.06.020
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Abstract

Brain vasopressin V(1A) receptors (V(1A)-R) and oxytocin receptors (OT-R) are important modulators of social behaviors. We recently showed that exposure to maternal separation (MS; 3 h daily, postnatal days 1-14) induces changes in social behaviors in juvenile and adult male rats. Here, we hypothesize that MS induces brain region-specific changes in V(1A)-R and OT-R across development, which in turn, may underlie MS-induced changes in social behaviors. We examined the effects of MS on V(1A)-R and OT-R binding in forebrain regions of juvenile (5 weeks), adolescent (8 weeks), and adult (16 weeks) male rats. Robust age-related changes were found for V(1A)-R and OT-R binding in several brain regions. For example, in the lateral septum V(1A)-R binding increased while OT-R binding decreased with age. Most notably, OT-R binding in the caudate putamen showed a 2-fold decrease while OT-R binding in the ventromedial hypothalamus showed a 4-fold increase with age. Importantly, exposure to MS interfered with these developmental changes in several brain regions. Specifically, MS significantly increased V(1A)-R binding in the piriform cortex (at adolescent and adult ages), the lateral septum (at juvenile age), the hypothalamic attack area (at adolescent age), and the dentate gyrus of the hippocampus (at adolescent age), and decreased V(1A)-R binding in the arcuate nucleus (at juvenile age). Moreover, OT-R binding was significantly lower in the agranular cortex (at juvenile and adolescent age), the lateral septum (at adult age) and the caudate putamen (at adult age), but higher in the medial preoptic area (at adolescent age) and ventromedial hypothalamus (at adult age) after exposure to MS. In conclusion, age-dependent changes in V(1A)-R and OT-R binding are likely associated with the maturation of behaviors, such as sexual and aggressive behaviors, while disruption of these changes by MS might contribute to previously observed changes in social behaviors after MS.

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Crossref · 10.1016/j.neuropharm.2009.06.020

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  • V1aR and OTR are abundantly expressed in the lateral septum in juvenile rats.

    “V1aR and the OTR are abundantly expressed in this area in juvenile rats (Lukas et al., 2010; Veenema et al., 2012)”

    From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Lukas et al., 2010

  • The injection site was chosen because it is positioned centrally in the region where males and females express high densities of V1aR and OTR binding in the lateral septum and corresponds with previous studies showing that pharmacological manipulations of AVP and OXT systems in the rat lateral septum altered social behavior.

    “This injection site was chosen because it is positioned centrally in the region where males and females express high densities of V1aR and OTR binding in the lateral septum (Lukas et al., 2010; Veenema et al., 2012; Figure 1) and because the injection site corresponds with previous studies showing that pharmacological manipulations of AVP and OXT systems in the rat lateral septum altered social”

    From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Lukas et al., 2010

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Authors
Lukas, M., Bredewold, R., Neumann, I. D., & Veenema, A. H.
Affiliations
University of Regensburg (DE)
Corresponding author
Veenema, A.H.
ORCID
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2010-01
Volume
58
Issue
1
Pages
78-87
ISSN
0028-3908 (ISSN-L)
DOI
10.1016/j.neuropharm.2009.06.020
OpenAlex
W2011628863
Cited by
183
References
87
Citations by year
2026: 4 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 20 · 2021: 15 · 2020: 11 · 2019: 21 · 2018: 18 · 2017: 10 · 2016: 12 · 2015: 10 · 2014: 14 · 2013: 11 · 2012: 8
FWCI
11.70
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
maternal separation, vasopressin V1a receptor, oxytocin receptor, receptor binding, brain development, social behavior, lateral septum, caudate-putamen, ventromedial hypothalamus, piriform cortex, dentate gyrus, arcuate nucleus, medial preoptic area, aggression, sexual behavior, young rats
MeSH terms
Age Factors, Aging, Analysis of Variance, Animals, Animals, Newborn, Arginine Vasopressin, Autoradiography, Brain, Iodine Isotopes, Male, Maternal Deprivation, Protein Binding, Time Factors, Vasopressins, Rats, Wistar, Receptors, Oxytocin, Rats

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