The regulation of oxytocin receptor binding in the ventromedial hypothalaimic nucleus by testosterone and its metabolites
Abstract
Oxytocin (OT) receptor binding in the ventromedial hypothalamic nucleus is regulated by testosterone (T) in male rats. However, T is metabolized in the brain, and many of the central effects of T are mediated by its metabolites. The experiments reported here were designed to determine whether T affects OT receptor binding directly or through the action of its metabolites 17 beta-estradiol and 5 alpha-dihydrotestosterone. Adult male rats were either sham operated or castrated and treated 1 week later with T propionate (TP), 17 beta-estradiol benzoate (EB), dihydrotestosterone benzoate (DHTB), DHTB plus EB, or oil. OT receptor binding was assessed autoradiographically using [125I]d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH2(9)]OVT. In addition, seminal vesicle weights were measured as an index of androgenic activity. These experiments showed that TP and DHTB plus EB increased OT receptor binding in the ventromedial hypothalamic nucleus to the levels in intact males. Treatment with EB alone partially reinstated binding to the levels in intact males, while DHTB treatment was without effect. Castrated males treated with either TP or DHTB had seminal vesicle weights comparable to those of gonadally intact males and greater than those of animals in all other steroid conditions, indicating that sufficient levels of circulating steroids were attained in these groups. These data suggest that the induction of hypothalamic OT receptor binding by T is the result of the combined actions of estradiol and dihydrotestosterone. However, the mechanism underlying this interaction is unknown.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Androgens and progesterone modulate oxytocin and oxytocin receptor expression, while estrogens seem to have the greatest impact on the oxytocin system.
“While androgens and progesterone modulate Oxt and Oxtr expression (72–75), it is the estrogens that seem to have the greatest impact on the Oxt system (68, 70, 74, 76–78).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [72]
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
The vasopressinergic innervation of the brain in normal and castrated rats
DeVries, G. J., Buijs, R. M., van Leeuwen, F. W., Caffé, A. R., & Swaab, D. F. (1985) · Journal of Comparative Neurology · doi:10.1002/cne.902330206 · Cited by 522 · see citing works
Oxytocin Secretion in Response to Cholecystokinin and Food: Differentiation of Nausea from Satiety
Verbalis, J. G., McCann, M. J., McHale, C. M., & Stricker, E. M. (1986) · Science · doi:10.1126/science.3715453 · Cited by 354 · see citing works
Influence of oxytocin on feeding behavior in the rat
Arletti, R., Benelli, A., & Bertolini, A. (1989) · Peptides · doi:10.1016/0196-9781(89)90082-x · Cited by 328 · see citing works
Romano, G. J., Krust, A., & Pfaff, D. W. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-8-1295 · Cited by 205 · see citing works
Estradiol Modulates Density of Putative Oxytocin Receptors’ in Discrete Rat Brain Regions
de Kloet, R., Voorhuis, D. A. M., Boschma, Y., & Elands, J. (2008) · Neuroendocrinology · doi:10.1159/000124680 · Cited by 198 · see citing works
Oxytocin and vasopressin secretion in response to stimuli producing learned taste aversions in rats.
Verbalis, J. G., McHale, C. M., Gardiner, T. W., & Stricker, E. M. (1986) · Behavioral Neuroscience · doi:10.1037//0735-7044.100.4.466 · Cited by 171 · see citing works
Lieberburg, I. M., & McEwen, B. S. (1977) · Endocrinology · doi:10.1210/endo-100-2-588 · Cited by 165 · see citing works
Sar, M., & Stumpf, W. E. (1977) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(77)90063-2 · Cited by 140 · see citing works
Androgens: Biochemistry, Physiology, and Clinical Significance
(1956) · JAMA · doi:10.1001/jama.1956.02970010118045 · Cited by 134 · see citing works
Localized actions of progesterone in hypothalamus involve oxytocin.
Schumacher, M., Coirini, H., Frankfurt, M., & McEwen, B. S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.17.6798 · Cited by 130 · see citing works
Postpartum Increases in Brain Oxytocin Binding
Insel, T. R. (2008) · Neuroendocrinology · doi:10.1159/000124694 · Cited by 116 · see citing works
Argiolas, A., Melis, M. R., Vargiu, L., & Gessa, G. L. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90168-3 · Cited by 110 · see citing works
Handa, R. J., Roselli, C. E., HORTON, L. E., & Resko, J. A. (1987) · Endocrinology · doi:10.1210/endo-121-1-233 · Cited by 100 · see citing works
Johnson, A. E., Coirini, H., Ball, G. F., & McEwen, B. S. (1989) · Endocrinology · doi:10.1210/endo-124-1-207 · Cited by 94 · see citing works
Johnson, A. E., Ball, G. F., Coirini, H., Harbaugh, C. R., McEwen, B. S., & Insel, T. R. (1989) · Endocrinology · doi:10.1210/endo-125-3-1414 · Cited by 87 · see citing works
5α-Dihydrotestosterone (DHT) Receptors in Rat Brain and Pituitary Cell Nuclei
Lieberburg, I. M., MacLusky, N. J., & McEwen, B. S. (1977) · Endocrinology · doi:10.1210/endo-100-2-598 · Cited by 72 · see citing works
Coirini, H., Johnson, A. E., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000125221 · Cited by 71 · see citing works
Interaction of androgens and estrogens in the control of sexual behavior in male Japanese quail
Balthazart, J., Schumacher, M., & Malacarne, G. (1985) · Physiology & Behavior · doi:10.1016/0031-9384(85)90330-0 · Cited by 71 · see citing works
Krey, L. C., MacLusky, N. J., Davis, P. G., Lieberburg, I. M., & Roy, E. J. (1982) · Endocrinology · doi:10.1210/endo-110-6-2159 · Cited by 59 · see citing works
Effect of Estrogen on Androgen Receptor Dynamics in Female Rat Pituitary*
Handa, R. J., Stadelman, H. L., & Resko, J. A. (1987) · Endocrinology · doi:10.1210/endo-121-1-84 · Cited by 50 · see citing works
Estrogen Down-Regulation of Androgen Receptors in Cultured Human Mammary Cancer Cells (MCF-7)*
Stover, E. P., Krishnan, A. V., & Feldman, D. (1987) · Endocrinology · doi:10.1210/endo-120-6-2597 · Cited by 35 · see citing works
Jones, K. J., McEwen, B. S., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000125063 · Cited by 26 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689 · see citing works
Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., Bartz, J. A., Yee, J. R., & van Zuiden, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.019 · Cited by 620 · see citing works
Insel, T. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90073-g · Cited by 487 · see citing works
Francis, D. D., Young, L. J., Meaney, M. J., & Insel, T. R. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2002.00776.x · Cited by 415 · see citing works
Self-citationMcEwen, B. S., & Woolley, C. S. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90022-1 · Cited by 305 · see citing works
Bethlehem, R. A. I., van Honk, J., Auyeung, B., & Baron-Cohen, S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.011 · Cited by 285 · see citing works
Oxytocin, vasopressin, and autism: Is there a connection?
Insel, T. R., O’Brien, D. J., & Leckman, J. F. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00142-5 · Cited by 226 · see citing works
Oxytocin and Vasopressin Receptors and Species-Typical Social Behaviors
Young, L. J. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1548 · Cited by 211 · see citing works
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181 · see citing works
Zhang, L., Ma, W., Barker, J. L., & Rubinow, D. R. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00234-1 · Cited by 170 · see citing works
TRIBOLLET, E., DUBOIS‐DAUPHIN, M., DREIFUSS, J. J., BARBERIS, C., & JARD, S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34343.x · Cited by 156 · see citing works
Neuropeptides and sexual behaviour
Argiolas, A. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00068-8 · Cited by 148 · see citing works
Neuropeptides and central control of sexual behaviour from the past to the present: A review
Argiolas, A., & Melis, M. R. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.006 · Cited by 141 · see citing works
Sex, Receptors, and Attachment: A Review of Individual Factors Influencing Response to Oxytocin
MacDonald, K. S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00194 · Cited by 119 · see citing works
Cloning, Novel Promoter Sequence, and Estrogen Regulation of a Rat Oxytocin Receptor Gene
Bale, T. L., & Dorsa, D. M. (1997) · Endocrinology · doi:10.1210/endo.138.3.4998 · Cited by 118 · see citing works
Gonadal steroids have paradoxical effects on brain oxytocin receptors
Insel, T. R., Young, L., Witt, D. M., & Crews, D. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00531.x · Cited by 113 · see citing works
Oxytocin facilitates social approach behavior in women
Preckel, K., Scheele, D., Kendrick, K. M., Maier, W., & Hurlemann, R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00191 · Cited by 111 · see citing works
Oxytocin and vasopressin: genetics and behavioral implications
Caldwell, H. K., & Young, W. S. (2006) · Handbook of Neurochemistry and Molecular Neurobiology · doi:10.1007/978-0-387-30381-9_25 · Cited by 113 · see citing works
Oxytocin and Vasopressin: Genetics and Behavioral Implications
Caldwell, H. K., & Young, W. S. (2006) · Springer eBooks · doi:10.1007/0-387-30395-2_25 · Cited by 113 · see citing works
OxytocinSynthesis, Secretion, and Reproductive Functions
BURBACH, J., YOUNG, L., & RUSSELL, J. (2006) · Knobil and Neill's Physiology of Reproduction · doi:10.1016/b978-012515400-0/50063-4 · Cited by 113 · see citing works
Gene targeting approaches to neuroendocrinology: oxytocin, maternal behavior, and affiliation
Young, L. J., Winslow, J. T., Wang, Z., Gingrich, B., Guo, Q., Matzuk, M. M., & Insel, T. R. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1377 · Cited by 105 · see citing works
Broad, K. D., Lévy, F., Evans, G., Kimura, T., Keverne, E. B., & Kendrick, K. M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00782.x · Cited by 100 · see citing works
Oxytocin receptor mRNA expression in the ventromedial hypothalamus during the estrous cycle
Bale, T., Dorsa, D. M., & Johnston, C. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05058.1995 · Cited by 98 · see citing works
A review on the relationship between testosterone and life-course persistent antisocial behavior
Yildirim, B. O., & Derksen, J. J. L. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.07.044 · Cited by 88 · see citing works
Oxytocin during Development: Possible Organizational Effects on Behavior
Miller, T. V., & Caldwell, H. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00076 · Cited by 79 · see citing works
Testosterone, oxytocin, and the development of human parental care
Gordon, I., Pratt, M., Bergunde, K., Zagoory‐Sharon, O., & Feldman, R. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.05.016 · Cited by 75 · see citing works
Bale, T. L., & Dorsa, D. M. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588251 · Cited by 65 · see citing works
INSEL, T. R., YOUNG, L., & WANG, Z. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51928.x · Cited by 56 · see citing works
Oxytocin receptor binding in the hypothalamus during gestation in rats
Bealer, S. L., Lipschitz, D. L., Ramoz, G., & Crowley, W. R. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00766.2005 · Cited by 54 · see citing works
Szymanska, M., Schneider, M., Chateau‐Smith, C., Nezelof, S., & Vulliez‐Coady, L. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12544 · Cited by 54 · see citing works
Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms
Liu, C. M., Spaulding, M. O., Rea, J. J., Noble, E. E., & Kanoski, S. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910859 · Cited by 53 · see citing works
Evolving the neuroendocrine physiology of human and primate cooperation and collective action
Trumble, B. C., Jaeggi, A. V., & Gurven, M. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0014 · Cited by 50 · see citing works
Chapter II Neurobiology and neuropathology of the human hypothalamus
Swaab, D. F. (1997) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(97)80004-8 · Cited by 100 · see citing works
Yildirim, B. O., & Derksen, J. J. L. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.08.016 · Cited by 49 · see citing works
Dubois‐Dauphin, M., Theler, J., Zaganidis, N., Dominik, W., Tribollet, E., Pévet, P., Charpak, G., & Dreifuss, J.-J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11163 · Cited by 47 · see citing works
Polymorphism and genetic mapping of the human oxytocin receptor gene on chromosome 3
Michelini, S., Urbanek, M., Dean, M. C., & Goldman, D. A. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320600303 · Cited by 46 · see citing works
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.002 · Cited by 47 · see citing works
Hassan, H. A., Enright, W. J., Tucker, H. A., & Merkel, R. A. (2001) · Steroids · doi:10.1016/s0039-128x(00)00168-9 · Cited by 45 · see citing works
Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances
Melis, M. R., & Argiolas, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910376 · Cited by 44 · see citing works
Reduced binding of oxytocin in the rat brain during aging
Arsenijévic, Y., Dreifuss, J. J., Vallet, P. G., Marguerat, A., & Tribollet, E. (1995) · Brain Research · doi:10.1016/0006-8993(95)01020-v · Cited by 43 · see citing works
Johnson, A. E. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34367.x · Cited by 43 · see citing works
Bale, T. L., & Dorsa, D. M. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00287-8 · Cited by 40 · see citing works
Expression of the Oxytocin and Vasopressin Genes
Young, W. S. (1992) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1992.tb00201.x · Cited by 47 · see citing works
Neurochemical organization of the ventral striatum’s olfactory tubercle
Cansler, H. L., Wright, K. N., Stetzik, L. A., & Wesson, D. W. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14919 · Cited by 34 · see citing works
Oxytocin and social anxiety: Interactions with sex hormones
Schneider, E., Müller, L. E., Ditzen, B., Herpertz, S. C., & Bertsch, K. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105224 · Cited by 33 · see citing works
Pharmacology of Oxytocin and Vasopressin Receptors in the Central and Peripheral Nervous Systema
Barberis, C., Audigier, S., Durroux, T., Elands, J., Schmidt, A., & Jard, S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34344.x · Cited by 32 · see citing works
Sex and estrogenic effects on coexpression of mRNAs in single ventromedial hypothalamic neurons
Devidze, N., Mong, J. A., Jasnow, A. M., Kow, L., & Pfaff, D. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507144102 · Cited by 32 · see citing works
Administration of an oxytocin receptor antagonist attenuates sexual motivation in male rats
Blitzer, D. S., Wells, T. E., & Hawley, W. R. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.06.002 · Cited by 25 · see citing works
Bale, T. L. (1995) · Endocrinology · doi:10.1210/en.136.1.27 · Cited by 102 · see citing works
Krémarik, P., Freund‐Mercier, M. J., & Stoeckel, M. E. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00759.x · Cited by 22 · see citing works
Oxytocin, vasopressin and their interplay with gonadal steroids
Dhakar, M. B., Stevenson, E. L., & Caldwell, H. K. (2013) · Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior · doi:10.1017/cbo9781139017855.003 · Cited by 20 · see citing works
Region-specific effect of testosterone on oxytocin receptor binding in the brain of the aged rat
Arsenijévic, Y., & Tribollet, E. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01429-7 · Cited by 20 · see citing works
Coenjaerts, M., Adrovic, B., Trimborn, I., Philipsen, A., Hurlemann, R., & Scheele, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-29754-y · Cited by 14 · see citing works
The Neurochemistry of Limbic-Hypothalamic Circuits Regulating Sexual Receptivity
Micevych, P. E., & Sinchak, K. (2006) · Springer eBooks · doi:10.1007/978-0-387-30405-2_4 · Cited by 16 · see citing works
Coenjaerts, M., Trimborn, I., Adrovic, B., Stoffel‐Wagner, B., Cahill, L. F., Philipsen, A., Hurlemann, R., & Scheele, D. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119689 · Cited by 17 · see citing works
Hormonal regulation of vasotocin receptor mRNA in a seasonally breeding songbird
Grozhik, A. V., Horoszko, C. P., Horton, B. M., Hu, Y., Voisin, D. A., & Maney, D. L. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.11.009 · Cited by 14 · see citing works
Projections from the ventromedial nucleus of the hypothalamus contain oxytocin binding sites
Johnson, A. E., Harbaugh, C. R., & Gelhard, R. E. (1991) · Brain Research · doi:10.1016/0006-8993(91)90815-d · Cited by 12 · see citing works
Yohn, C. N., Leithead, A. B., Ford, J. D., Gill, A., & Becker, E. A. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00181 · Cited by 9 · see citing works
Dihydrotestosterone-sensitive neurons in the male rat ventromedial hypothalamus
Suga, S., & Sakuma, Y. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90253-4 · Cited by 10 · see citing works
Intranasal oxytocin, testosterone reactivity, and human competitiveness
Cherki, B. R., Winter, E., Mankuta, D., & Israel, S. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105352 · Cited by 8 · see citing works
AVP V1a-R expression in the rat hypothalamus around parturition: relevance to antipyresis at term
Clerget-Froidevaux, M.-S. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00114-6 · Cited by 9 · see citing works
Vasopressin and Oxytocin Receptors and the Developing Brain
Boer, G. J. (1993) · Springer eBooks · doi:10.1007/978-94-011-1540-7_12 · Cited by 9 · see citing works
Transcriptional Regulation of the Oxytocin Receptor Gene
Bale, T. L., & Dorsa, D. M. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_38 · Cited by 7 · see citing works
Malik, K. F., Feder, H. H., & Morrell, J. I. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00486.x · Cited by 7 · see citing works
The Placental Steroid Hypothesis of Human Brain Evolution
Tsompanidis, A., Burton, G. J., Baron‐Cohen, S., & Dunbar, R. (2025) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.70003 · Cited by 4 · see citing works
Coenjaerts, M., Trimborn, I., Adrovic, B., Stoffel‐Wagner, B., Cahill, L. F., Philipsen, A., Hurlemann, R., & Scheele, D. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.22.469500 · Cited by 2 · see citing works
Romero‐Morales, L., Nicole Rojas-de la, O., López-Serrano, D., García‐Saucedo, B., Carmona, A., & Luis, J. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115945 · Cited by 1 · see citing works
Oxytocin – the prosocial molecule?
Preckel, K. (2015) · bonndoc (University of Bonn)
Szymanska, M. (2016) · theses.fr (ABES) · doi:10.70675/5ebf3333z256cz402dz8340z24153a59aef8
- Authors
- JOHNSON, A. E., COIRINI, H., INSEL, T. R., & McEWEN, B. S.
- Affiliations
- National Institute of Mental Health (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1991-02
- Volume
- 128
- Issue
- 2
- Pages
- 891-896
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1965616857
- Cited by
- 71
- References
- 23
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 6 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 6 · 2012: 3
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS007080, NS 07080)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- oxytocin receptor, ventromedial hypothalamus, testosterone, estradiol, dihydrotestosterone, androgen-estrogen interaction, castration, seminal vesicle weight, androgenic activity, male rats
- MeSH terms
- Animals, Autoradiography, Estradiol, Male, Orchiectomy, Oxytocin, Receptors, Cell Surface, Seminal Vesicles, Dihydrotestosterone, Testosterone, Ventromedial Hypothalamic Nucleus, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
