Cited by 167Dementia and Cognitive Impairment ResearchCircadian rhythm and melatoninAlzheimer's disease research and treatments

Possible therapeutic value of melatonin in mild cognitive impairment: A retrospective study

Furio, Analía M., Brusco, Luis I., Cardinali, D. P.·2007·Journal of Pineal Research

Abstract

Mild cognitive impairment (MCI) is an etiologically heterogeneous syndrome characterized by cognitive impairment preceding dementia. Approximately 12% of MCI patients convert to Alzheimer's disease (AD) or other dementia disorders every year. In the present report we retrospectively examined the initial and final neuropsychological assessment of 50 MCI outpatients, 25 of whom had received daily 3-9 mg of a fast-release melatonin preparation p.o. at bedtime for 9-18 months. Melatonin was given in addition to the standard medication prescribed by the attending psychiatrist. Patients treated with melatonin showed significantly better performance in Mini Mental State Examination and the cognitive subscale of the Alzheimer's Disease Assessment Scale. After application of a battery of neuropsychological tests including Mattis' test, Digit-symbol test, Trail A and B tasks and the Rey's verbal test, better performance was found in melatonin-treated patients, except for the Digit-symbol test score which remained unchanged. Abnormally high Beck Depression Inventory scores decreased in melatonin-treated patients, concomitantly with an improvement in wakefulness and sleep quality. The results suggest that melatonin can be a useful add-on drug for treating MCI in a clinical setting.

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Crossref · 10.1111/j.1600-079x.2007.00491.x

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Authors
Furio, A. M., Brusco, L. I., & Cardinali, D. P.
Affiliations
Universidad de Buenos Aires (AR)
Corresponding author
Cardinali, D. P.
Venue
Journal of Pineal Research
Publisher
Wiley
Published
2007-08-28
Volume
43
Issue
4
Pages
404-409
ISSN
  • 0742-3098 (ISSN-L)
  • 1600-079X
OpenAlex
W1999900894
Cited by
167
References
35
Citations by year
2026: 2 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 13 · 2017: 8 · 2016: 12 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 11
FWCI
7.03
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pineal Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
melatonin, mild cognitive impairment, Alzheimer's disease, dementia prevention, cognitive function, sleep quality, depression, adjunctive therapy, neuropsychological assessment
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Central Nervous System Depressants, Cognition Disorders, Female, Humans, Male, Melatonin, Neuropsychological Tests, Outpatients, Retrospective Studies

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