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Cited by 42Circadian rhythm and melatoninRetinal Development and DisordersVisual perception and processing mechanisms

Thetau mutation shortens the period of rhythmic photoreceptor outer segment disk shedding in the hamster

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Grace, Michael S., Wang, Lori Amy, Pickard, Gary E., Besharse, Joseph C., Menaker, Michael·1996·Brain Research
DOI 10.1016/0006-8993(96)00600-2
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Abstract

The outer segments of vertebrate retinal photoreceptors undergo periodic shedding of membrane from their distal tips. This circadian rhythm of disk shedding persists with a period of about 24 h in the absence of external time cues. A circadian oscillator controlling photoreceptor disk shedding may exist in the eye, but in addition, the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN) may also influence ocular rhythms including that of disk shedding. The tau mutation directly affects the SCN, and shortens the period of locomotor activity from 24 h in wild-type hamsters to 20 h in homozygous mutants. Here we show that homozygous tau-mutant hamsters in a 20-h light/dark cycle exhibit a 20-h oscillation in the rate of disk shedding, with peak phagosome numbers in the retinal pigmented epithelium occurring just after light onset. The numbers of phagosomes are significantly elevated from mid-dark levels prior to light onset, indicating that the disk shedding cycle anticipates dawn. Under conditions of constant darkness, the disk shedding rhythm in tau-mutant hamsters persists with a period of approximately 20 h. These results indicate that a rhythm of retinal photoreceptor outer segment disk shedding exists in the hamster eye, and that the period of this rhythm is shortened by the tau mutation.

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  • Most animals (including mouse, rat, cat, hamster, Xenopus laevis, goldfish, rabbit, and chick) appear to be entrained to a circadian rhythm, which is cued by the light/dark cycle and persists even when the animal is maintained in absolute darkness, but not in absolute light.

    “Most animals (including mouse, rat, cat, hamster, Xenopus laevis, goldfish, rabbit, and chick) appear to be entrained to a circadian rhythm, which is cued by the light/dark cycle and persists even when the animal is maintained in absolute darkness (LaVail, 1976; Besharse et al., 1977; Grace et al., 1996), but not in absolute light (Teirstein et al., 1980).”

    From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Grace et al., 1996

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Authors
Grace, M. S., Wang, L. A., Pickard, G. E., Besharse, J. C., & Menaker, M.
Affiliations
  • U.S. National Science Foundation (US)
  • University of Pennsylvania (US)
  • University of Kansas Medical Center (US)
Corresponding author
Grace, Michael S.
ORCID
Besharse, Joseph C.
Venue
Brain Research
Publisher
Elsevier BV
Published
1996-09
Volume
735
Issue
1
Pages
93-100
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(96)00600-2
OpenAlex
W1972651922
Cited by
42
References
20
Citations by year
2025: 1 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 2 · 2012: 1
FWCI
0.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Research (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Microsoft
  • National Institutes of Health
  • U.S. Air Force (F49620)
  • National Eye Institute (EY-02414, R01EY002414, EY06664)
  • Air Force Office of Scientific Research (F49620)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
circadian rhythm, retinal photoreceptors, suprachiasmatic nucleus, circadian clock, phagosome, retinal pigment epithelium, hamster, constant darkness
MeSH terms
Adaptation, Ocular, Animals, Behavior, Animal, Circadian Rhythm, Dark Adaptation, Female, Cricetinae, Male, Mesocricetus, Mutation, Periodicity, Photoreceptor Cells, Pigment Epithelium of Eye, tau Proteins

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