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Effect upon the EEG of acute injury to the brain stem activating system

Lindsley, D.B., Bowden, J.W., Magoun, H.W.·1949·Electroencephalography and Clinical Neurophysiology
DOI 10.1016/0013-4694(49)90221-7
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Abstract

The effect upon the EEG in the unanesthetized "ecéphale isolé" of acute brain stem lesions in a position to involve the ascending reticular activating system has been studied. Elimination of the bulbar segment was without marked effect. Some synchronization followed elimination of the pons, but the most pronounced and prolonged changes occurred as a result of mesencephalic transection, or of discrete injury to the midbrain tegmentum or basal diencephalon, following which the EEG activation pattern of low voltage fast activity was reduced or abolished and the cortical record became dominated by recurring bursts or spindles of high voltage slow waves like those of normal sleep or barbiturate anesthesia. Bursts could be recorded from the intralaminar and other nuclei of the thalamus and these thalamic bursts were abolished by acute decortication. Conversely, cortical bursts were abolished by acute thalamic lesions. Possible interrelations of these regions in this activity is discussed. These results offer an explanation for the clinical observation of somnolence following basal injury to the brain, and suggest that a maintained influence of the ascending brain stem activating system underlies wakefulness, while absence of this influence precipitates sleep.

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Research works printed but not linked: 23

  1. Bailey, 1944, Effects of lesions of the periaqueductal gray matter of the Macaca mulatta, J. Neuropath. Exp. Neurol., 3, 69, 10.1097/00005072-194401000-00005 · DOI
  2. Blake, 1939, Factors influencing brain potentials during sleep, J. Neurophysiol., 2, 48, 10.1152/jn.1939.2.1.48 · DOI
  3. Bremer, 1935, Cerveau “isolé” et physiologie du sommeil, C. R. Soc. Biol., Paris, 118, 1235
  4. Bremer, 1936, Activité électrique du cortex cérébral dans les états de sommeil et de veille chez le chat, C. R. Soc. Biol., Paris, 122, 464
  5. Bremer, 1936, Action de différents narcotiques sur les activités électriques spontanée et réflexe du cortex cérébral, C. R. Soc. Biol., Paris, 121, 861
  6. Bremer, 1937, Etude oscillographique des activités sensorielles du cortex cérébral, C. R. Soc. Biol., Paris, 124, 842
  7. Bremer, 1937, L'activité cérébrale au cours du sommeil et de la narcose. Contribution a l'étude du mécanisme du sommeil, Bull. Acad. Med. Belg., 68
  8. Bremer, 1938, Effets de la déafférentation compléte d'une région de l'écorce cérébrale sur son activité électrique spontanée, C. R. Soc. Biol., Paris, 127, 355
  9. Bremer, 1949, Considérations sur l'origine et la nature des “ondes” cérébrales, EEG Clin. Neurophysiol., 1, 177
  10. Cannon, 1927, The James-Lange theory of emotions: a critical examination and an alternative theory, Amer. J. Psychol., 39, 106, 10.2307/1415404 · DOI · Paper page
  11. Davis, 1938, Human brain potentials during the onset of sleep, J. Neurophysiol., 1, 24, 10.1152/jn.1938.1.1.24 · DOI
  12. Dempsey, 1942, The production of rhythmically recurrent cortical potentials after localized thalamic stimulation, Amer. J. Physiol., 135, 293, 10.1152/ajplegacy.1941.135.2.293 · DOI
  13. Dempsey, 1942, The interaction of certain spontaneous and induced cortical potentials, Amer. J. Physiol., 135, 301, 10.1152/ajplegacy.1941.135.2.301 · DOI
  14. Derbyshire, 1936, Effects of anesthetics on action potentials in cerebral cortex of the cat, Amer. J. Physiol., 116, 577, 10.1152/ajplegacy.1936.116.3.577 · DOI
  15. Jasper, 1948, Charting the sea of brain waves, Science, 108, 343, 10.1126/science.108.2805.343 · DOI
  16. Jasper, 1949, Diffuse projection systems: the integrative action of the thalamic reticular system, EEG Clin. Neurophysiol., 1, 405, 10.1016/0013-4694(49)90060-7 · DOI
  17. Jiménez-Castellanos, 1949, Thalamus of the cat in Horsley-Clarke coordinates, J. Comp. Neurol., 10.1002/cne.900910208 · DOI
  18. Morison, 1945, Electrical activity of the thalamus and basal ganglia in decorticate cats, J. Neurophysiol., 8, 309, 10.1152/jn.1945.8.5.309 · DOI
  19. Morison, 1943, Spontaneous electrical activity of thalamus and other forebrain structures, J. Neurophysiol., 6, 243, 10.1152/jn.1943.6.4.243 · DOI
  20. Moruzzi, 1949, Brain stem reticular formation and activation of the EEG, EEG Clin. Neurophysiol., 1, 455, 10.1016/0013-4694(49)90219-9 · DOI · Paper page
  21. Moruzzi, 1950, Variations in cortical excitability with spindle-bursts, EEG Clin. Neurophysiol.
  22. Ranson, 1939, Somnolence caused by hypothalamic lesions in the monkey, Arch. Neurol. Psychiat., Chicago, 41, 1, 10.1001/archneurpsyc.1939.02270130011001 · DOI
  23. Swank, 1949, Effects of barbiturates and ether in spontaneous electrical activity of dog brain, J. Neurophysiol., 12, 137, 10.1152/jn.1949.12.2.137 · DOI

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Metadata

Authors
Lindsley, D. B., Bowden, J. W., & Magoun, H. W.
Venue
Electroencephalography and Clinical Neurophysiology
Publisher
Elsevier BV
Published
1949-01
Volume
1
Issue
1-4
Pages
475-486
ISSN
0013-4694
DOI
10.1016/0013-4694(49)90221-7
Cited by
335
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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