Cited by 103Parkinson's Disease Mechanisms and TreatmentsCoenzyme Q10 studies and effectsNuclear Receptors and Signaling

Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity

Schulz, Jörg B., Ross Henshaw, D., Matthews, Russell T., Flint Beal, M.·1995·Experimental Neurology

Abstract

1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) produces Parkinsonism in both experimental animals and in man. MPTP is metabolized to 1-methyl-4-phenylpridinium, an inhibitor of mitochondrial complex I. MPTP administration produces ATP depletions in vivo, which may lead to secondary excitotoxicity and free radical generation. If this is the case then agents which improve mitochondrial function or free radical scavengers should attenuate MPTP neurotoxicity. In the present experiments three regimens of MPTP administration produced varying degrees of striatal dopamine depletion. A combination of coenzyme Q10 and nicotinamide protected against both mild and moderate depletion of dopamine. In the MPTP regimen which produced mild dopamine depletion nicotinamide or the free radical spin trap N-tert-butyl-alpha-(2-sulfophenyl)-nitrone were also effective. There was no protection with a MPTP regimen which produced severe dopamine depletion. These results show that agents which improve mitochondrial energy production (coenzyme Q10 and nicotinamide) and free radical scavengers can attenuate mild to moderate MPTP neurotoxicity.

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Crossref · 10.1016/0014-4886(95)90033-0

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  • Nicotinamide prevents MPTP induced neurodegeneration in mice.

    “Nicotinamide prevents MPTP induced neurodegeneration in mice139.”

    From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [139]

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Authors
Schulz, J. B., Ross Henshaw, D., Matthews, R. T., & Flint Beal, M.
Affiliations
Harvard University (US)
Venue
Experimental Neurology
Publisher
Elsevier BV
Published
1995-04
Volume
132
Issue
2
Pages
279-283
ISSN
0014-4886 (ISSN-L)
OpenAlex
W2014192866
Cited by
103
References
30
Citations by year
2025: 1 · 2022: 2 · 2020: 2 · 2019: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 9
FWCI
4.88
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01ns031579-05)
  • National Institute of Neurological Disorders and Stroke (NS 16367, NS31579)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
MPTP-induced neurotoxicity, coenzyme Q10, nicotinamide, parkinsonism, striatal dopamine depletion, mitochondrial complex I inhibition, mitochondrial energy production, radical scavengers, excitotoxicity, ATP depletion
MeSH terms
Animals, Benzenesulfonates, Coenzymes, Corpus Striatum, Free Radicals, Male, Mice, Inbred Strains, Niacinamide, Spin Labels, Ubiquinone, Neuroprotective Agents, MPTP Poisoning, Mice

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