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Heterogeneous lipoprotein (a) size isoforms differ by their interaction with the low density lipoprotein receptor and the low density lipoprotein receptor‐related protein/α2‐macroglobulin receptor

März, Winfried, Beckmann, Angela, Scharnagl, Hubert, Siekmeier, Rüdiger, Mondorf, Uli, Held, Irmtraud, Schneider, Wolfgang, Preissner, Klaus T., Curtiss, Linda K., Groß, Werner, Hüttinger, Manfred·1993·FEBS Letters
DOI 10.1016/0014-5793(93)81087-g
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Abstract

Lipoprotein (a) (Lp(a)) is a complex of low density lipoprotein (LDL) with apolipoprotein (apo) (a). To examine the size distribution of L p(a), plasma was separated by fast flow gel filtration and L p(a): B complexes were determined in the eluate by enzyme immunoassays, in which detection was performed with monoclonal antibodies specific for apoB Lp(a): B particles displayed apparent molecular masses (M r ) of 2 × 10 6 to at least 10 × 10 6. Lp(a) size isoforms differed by the expression of apoB epitopes and their interaction with cultured human skin fibroblasts. LDL was more effective in inhibiting binding, uptake, and degradation of low M r , Lp(a) than of high M r Lp(a). In contrast, Glu‐plasmmogen, α 2‐macroglobulin and tissue‐type plasminogen activator were more effective in competing for the cellular degradation of high M r Lp(a) than of low M r Lp(a). Ligand blotting revealed that Lp(a) bound to the low density lipoprotein receptor, the low density lipoprotein receptor‐related protein/α 2‐macroglobulin receptor (LRP) and to two other endosomal membrane proteins. We propose that the LDL receptor preferentially internalizes low M r Lp(a), whereas LRP may have a role in the clearance of high M r Lp(a).

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  • Several other candidate Lp(a) receptors have been proposed, including other lipoprotein receptors, toll-like receptors, scavenger receptors, lectins, and plasminogen receptors.

    “Over time, several other candidate Lp(a) receptors have been proposed, including other lipoprotein receptors49,50, toll-like receptors51, scavenger receptors52,53, lectins26,54, and plasminogen receptors29,33.”

    From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [50]

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Metadata

Authors
März, W., Beckmann, A., Scharnagl, H., Siekmeier, R., Mondorf, U., Held, I., Schneider, W., Preissner, K. T., Curtiss, L. K., Groß, W., & Hüttinger, M.
Venue
FEBS Letters
Publisher
Wiley
Published
1993-07-05
Volume
325
Issue
3
Pages
271-275
ISSN
  • 0014-5793
  • 1873-3468
DOI
10.1016/0014-5793(93)81087-g
Cited by
67
References
1
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3052 d)

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