The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
p53 expression in nitric oxide‐induced apoptosis
Open accessAbstract
Nitric oxide (NO) is a diffusible messenger involved in several patho‐physiological processes including immune‐mediated cytotoxicity and neural cell killing. NO or the products of its redox chemistry can cause DNA damage and activate subsequent lethal reactions including energy depletion and cell necrosis. However, regardless of whether it is endogenously produced in response to cytokines, or generated by chemical breakdown of donor molecules, NO can also induce apoptosis in different systems. Here, we report that NO generation in response to a cytokine induced NO‐synthase or by NO donors stimulates the expression of the tumor suppressor gene, p53, in RAW 264.7 macrophages or pancreatic RINm5F cells prior to apoptosis. NO‐synthase inhibitors such as N G‐monomethyl‐l‐arginine prevent the inducible NO generation as well as p53 expression and apoptosis. Since p53 expression is linked to apoptosis in some cells exposed to DNA damaging agents, we suggest that NO‐induced apoptosis in these cell systems is the consequence of DNA damage and subsequent expression of this tumor suppressor gene.
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Cites
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p53 Mutations in Human Cancers
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p53 is required for radiation-induced apoptosis in mouse thymocytes
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Biochemistry of nitric oxide and its redox-activated forms
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Cited by
Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606
Nitric oxide and redox mechanisms in the immune response
Wink, D. A., Hines, H. B., Cheng, R. Y. S., Switzer, C. H., Flores-Santana, W., Vitek, M. P., Ridnour, L. A., & Colton, C. A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1010550 · Cited by 765
The multifaceted roles of nitric oxide in cancer
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Endoplasmic reticulum stress-mediated apoptosis in pancreatic β-cells
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Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin
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Metadata
- Authors
- Meßmer, U. K., Ankarcrona, M., Nicotera, P., & Brüne, B.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-11-21
- Volume
- 355
- Issue
- 1
- Pages
- 23-26
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2062757512
- Cited by
- 403
- References
- 5
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Meßmer, U. K., Ankarcrona, M., Nicotera, P., & Brüne, B. (1994). p53 expression in nitric oxide‐induced apoptosis. FEBS Letters. https://doi.org/10.1016/0014-5793(94)01161-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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