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A novel leptin receptor isoform in rat
Abstract
Five mouse and human leptin receptors (Ob‐R) have recently been identified, a long isoform (Ob‐Rb), preferentially expressed in hypothalamus, and 4 short isoforms, Ob‐Ra, Ob‐Rc, Ob‐Rd, and Ob‐Re. We have identified a new short isoform in the rat, r‐OB‐Rf, with 6 C‐terminal amino acids and a 3′ untranslated region without homology to other Ob‐R isoforms. Its higher expression in rat liver and spleen compared to brain, stomach, kidney, thymus, heart, lung and hypothalamus, contrasts with Ob‐Ra and Ob‐Rb homologues and raises possibilities of as yet unidentified roles for members of the growing Ob‐R gene family.
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Citations
Cites
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396
Diabetes, a New Mutation in the Mouse
Hummel, K. P., Dickie, M. M., & Coleman, D. L. (1966) · Science · doi:10.1126/science.153.3740.1127 · Cited by 990
Cited by
Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428
Wolf, G., Chen, S., Han, D. C., & Ziyadeh, F. N. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.29865 · Cited by 871
Intracellular signalling pathways activated by leptin
Frühbeck, G. (2006) · Biochemical Journal · doi:10.1042/bj20051578 · Cited by 696
Role of leptin and adiponectin in insulin resistance
Yadav, A., Kataria, M. A., Saini, V., & Yadav, A. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.12.007 · Cited by 637
Regulation of Body Weight in Humans
Jéquier, E., & Tappy, L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.451 · Cited by 373
Metadata
- Authors
- Wang, M.-Y., Yan, T. Z., Newgard, C. B., & Unger, R. H.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-08-26
- Volume
- 392
- Issue
- 2
- Pages
- 87-90
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2028336115
- Cited by
- 201
- References
- 5
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, M.-Y., Yan, T. Z., Newgard, C. B., & Unger, R. H. (1996). A novel leptin receptor isoform in rat. FEBS Letters. https://doi.org/10.1016/0014-5793(96)00790-9
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