Cited by 345Gastrointestinal motility and disordersDrug Solubulity and Delivery SystemsGastroesophageal reflux and treatments

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Circadian variation in gastric emptying of meals in humans

Goo, R.H., Moore, J.G., Greenberg, E., Alazraki, N.P.·1987·Gastroenterology

DOI 10.1016/0016-5085(87)90913-9

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Abstract

Circadian changes in drug absorption have been documented for several orally administered drugs in humans. To determine whether gastric emptying could account for these changes, morning (8 AM) and evening (8 PM) gastric emptying rates were measured in 16 healthy male subjects synchronized with diurnal activity and nocturnal rest. Gastric emptying half-times for the evening meal were significantly (p less than 0.001) longer for solids but not liquids when compared with morning emptying half-times. The increase in evening meal emptying time (53.6%) may account for the evening delay in reaching peak plasma concentrations documented for several drugs.

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Authors: Goo, R. H., Moore, J. G., Greenberg, E., & Alazraki, N. P.
Affiliations: United States Department of Veterans Affairs (US)
ORCID: Moore, J.G.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 1987-09
Volume: 93
Issue: 3
Pages: 515-518
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/0016-5085(87)90913-9
OpenAlex: W1472243025
Cited by: 345
References: 15
Citations by year: 2026: 4 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 10 · 2021: 14 · 2020: 33 · 2019: 9 · 2018: 11 · 2017: 15 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 10
FWCI: 5.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords: circadian rhythm, gastric emptying, meal timing, drug absorption, oral bioavailability, food effect on absorption
MeSH terms: Adult, Circadian Rhythm, Food, Gastric Emptying, Humans, Male

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Circadian variation in gastric emptying of meals in humans

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