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Cited by 167Hormonal and reproductive studiesLipoproteins and Cardiovascular HealthMenopause: Health Impacts and Treatments

Effect of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men

Zgliczynski, Stefan, Ossowski, Marcin, Slowinska-Srzednicka, Jadwiga, Brzezinska, Agnieszka, Zgliczynski, Wojciech, Soszynski, Piotr, Chotkowska, Ewa, Srzednicki, Marek +1 more·1996·Atherosclerosis
DOI 10.1016/0021-9150(95)05673-4
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Abstract

We investigated the effects of long-term testosterone replacement in hypogonadal and elderly men on lipids and lipoproteins. Twenty-two men with initial serum testosterone concentrations below 3.5 ng/ml took part in the study: 11 with hypopituitarism (1st group) and 11 otherwise healthy elderly men with low testosterone levels (2nd group). Testosterone deficiency was replaced by intramuscular injections of testosterone enanthate 200 mg every second week. Plasma levels of sex hormones, gonadotropins, SHBG, lipids and lipoproteins were determined before the treatment and after 3, 6 and 12 months of treatment. During the treatment serum testosterone and estradiol increased significantly, reaching normal levels. This was associated with a decrease in total cholesterol (from 225 +/- 16.9 mg/dl to 202 +/- 13.6 mg/dl after 6 months and 198 +/- 12.8 mg/dl after 1 year of testosterone administration, P < 0.0001 in men with hypoandrogenism associated with aging and from 255 +/- 12.1 mg/dl to 214 +/- 10.6 mg/dl after 6 months and 206 +/- 9 mg/dl after 1 year of treatment, P < 0.0001 in men with hypopituitarism) and LDL-cholesterol concentrations (from 139 +/- 12.5 mg/dl to 126 +/- 10.7 mg/dl after 6 months and 118 +/- 9.8 mg/dl after 1 year of testosterone administration, P < 0.0001 in men with hypoandrogenism associated with aging and from 178 +/- 10.3 mg/dl to 149 +/- 10.2 mg/dl after 6 months and 140 +/- 7.3 mg/dl after 1 year of treatment, P < 0.001 in men with hypopituitarism). However, no significant decrease in HDL-cholesterol levels or HDL2- and HDL3-cholesterol subfractions was observed. The effects of testosterone replacement therapy on lipids and lipoproteins were similar in both groups with different aetiology of hypogonadism. No side effects on the prostate were observed. The results of this study indicate that testosterone replacement therapy in hypogonadal and elderly men may have a beneficial effect on lipid metabolism through decreasing total cholesterol and atherogenic fraction of LDL-cholesterol without significant alterations in HDL-cholesterol levels or its subfractions HDL2-C and HDL3-C.

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Authors
Zgliczynski, S., Ossowski, M., Slowinska-Srzednicka, J., Brzezinska, A., Zgliczynski, W., Soszynski, P., Chotkowska, E., Srzednicki, M., & Sadowski, Z.
Affiliations
Institute of Cardiology (PL)
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
1996-03
Volume
121
Issue
1
Pages
35-43
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/0021-9150(95)05673-4
OpenAlex
W2012332628
Cited by
167
References
49
Citations by year
2026: 3 · 2025: 4 · 2024: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 3 · 2015: 8 · 2014: 9 · 2013: 7 · 2012: 8
FWCI
5.34
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
testosterone replacement therapy, hypogonadism, androgen deficiency, older men, hypopituitarism, lipids, lipoproteins, cholesterol, LDL cholesterol, HDL cholesterol, sex hormone-binding globulin, estradiol, testosterone enanthate, aging, prostate, gonadotropins, HDL subfractions, long-term treatment safety
MeSH terms
Adolescent, Adult, Aged, Aging, Arteriosclerosis, Gonadotropins, Pituitary, Humans, Hypogonadism, Hypopituitarism, Injections, Intramuscular, Lipids, Lipoproteins, Male, Middle Aged, Risk Factors, Sex Hormone-Binding Globulin, Gonadal Steroid Hormones, Testosterone

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