Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats
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We report the results of a series of experiments designed to determine the effects of ibandronate (Ibn) and risedronate (Ris) on a number of bone quality parameters in aged osteopenic rats to explain how bone material and bone mass may be affected by the dose of bisphosphonates (BP) and contribute to their anti-fracture efficacy. Eighteen-month old female rats underwent either ovariectomy or sham surgery. The ovariectomized (OVX) groups were left untreated for 2 months to develop osteopenia. Treatments started at 20 months of age as follows: sham and OVX control (treated with saline), OVX + risedronate 30 and 90 (30 or 90 microg/kg/dose), and OVX + ibandronate 30 and 90 (30 or 90 microg/kg/dose). The treatments were given monthly for 4 months by subcutaneous injection. At sacrifice at 24 months of age the 4th lumbar vertebra was used for microCT scans (bone mass, architecture, and degree of mineralization of bone, DMB) and histomorphometry, and the 6th lumbar vertebra, tibia, and femur were collected for biomechanical testing to determine bone structural and material strength, cortical fracture toughness, and tissue elastic modulus. The compression testing of the vertebral bodies (LVB6) was simulated using finite-element analysis (FEA) to also estimate the bone structural stiffness. Both Ibn and Ris dose-dependently increased bone mass and improved vertebral bone microarchitecture and mechanical properties compared to OVX control. Estimates of vertebral maximum stress from FEA were correlated with vertebral maximum load (r=0.5, p<0.001) and maximum stress (r=0.4, p<0.005) measured experimentally. Tibial bone bending modulus and cortical strength increased compared to OVX with both BP but no dose-dependent effect was observed. DMB and elastic modulus of trabecular bone were improved with Ibn 30 compared to OVX but were not affected in other BP-treated groups. DMB of tibial cortical bone showed no change with BP treatments. The fracture toughness examined in midshaft femurs did not change with BP even with the higher doses. In summary, the anti-fracture efficacy of BP is largely due to their preservation of bone mass and while the higher doses further improve the bone structural properties do not improve the localized bone material characteristics such as tissue strength, elastic modulus, and cortical toughness.
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Prolonged bisphosphonate treatment may have an adverse effect on cortical bone mineralization and quality such that cortical strength declines independent of bone mass.
“Prolonged bisphosphonates treatment may have an adverse effect on cortical bone mineralization and quality such that cortical strength decline independent of bone mass [54].”
From Prevention of glucocorticoid induced bone changes with beta-ecdysone (2015) · cites this paper as [54]
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Black, D. M., Cummings, S. R., Karpf, D. B., Cauley, J. A., Thompson, D. E., Nevitt, M. C., Bauer, D. C., Genant, H. K., Haskell, W. L., Marcus, R., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)07088-2 · Cited by 3,846 · see citing works
Marshall, D., Johnell, O., & Wedel, H. (1996) · BMJ · doi:10.1136/bmj.312.7041.1254 · Cited by 3,709 · see citing works
Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis
Black, D. M., Delmas, P. D., Eastell, R., Reid, I. R., Boonen, S., Cauley, J. A., Cosman, F., Lakatos, P., Leung, P. C., Man, Z., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067312 · Cited by 2,986 · see citing works
Liberman, U. A., Weiss, S. R., Bröll, J., Minne, H. W., Quan, H., Bell, N. H., Rodriguez-Portales, J. A., Downs, R. W., Dequeker, J., Favus, M. J., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511303332201 · Cited by 2,276 · see citing works
Basic biomechanical measurements of bone: A tutorial
Turner, C. H., & Burr, D. B. (1993) · Bone · doi:10.1016/8756-3282(93)90081-k · Cited by 1,666 · see citing works
Reginster, J.-Y., Minne, H. W., Sorensen, O. H., Hooper, M., Roux, C., Brandi, M. L., Lund, B., Ethgen, D., Pack, S., Roumagnac, I., et al. (2000) · Osteoporosis International · doi:10.1007/s001980050010 · Cited by 1,580 · see citing works
Ten Years' Experience with Alendronate for Osteoporosis in Postmenopausal Women
Bone, H. G., Hosking, D., Devogelaer, J.-P., Tucci, J. R., Emkey, R. D., Tonino, R. P., Rodriguez-Portales, J. A., Downs, R. W., Gupta, J., Santora, A. C., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa030897 · Cited by 1,347 · see citing works
van Rietbergen, B., Weinans, H., Huiskes, R., & Odgaard, A. (1995) · Journal of Biomechanics · doi:10.1016/0021-9290(95)80008-5 · Cited by 865 · see citing works
On the dependence of the elasticity and strength of cancellous bone on apparent density
Rice, J. C., Cowin, S. C., & Bowman, J. A. (1988) · Journal of Biomechanics · doi:10.1016/0021-9290(88)90008-5 · Cited by 726 · see citing works
Mashiba, T., Hirano, T., Turner, C. H., Forwood, M. R., Johnston, C. C., & Burr, D. B. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.4.613 · Cited by 687 · see citing works
IX: Summary of Meta-Analyses of Therapies for Postmenopausal Osteoporosis
Cranney, A., Guyatt, G. H., Griffith, L. E., Wells, G., Tugwell, P., Rosen, C. J., & The Osteoporosis Methodology Group (2002) · Endocrine Reviews · doi:10.1210/er.2001-9002 · Cited by 597 · see citing works
Boivin, G., Chavassieux, P., Santora, A. C., Yates, J., & Meunier, P. J. (2000) · Bone · doi:10.1016/s8756-3282(00)00376-8 · Cited by 573 · see citing works
Low-Energy Femoral Shaft Fractures Associated With Alendronate Use
Neviaser, A. S., Lane, J. M., Lenart, B. A., Edobor‐Osula, F., & Lorich, D. G. (2008) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0b013e318172841c · Cited by 525 · see citing works
Subtrochanteric insufficiency fractures in patients on alendronate therapy
Goh, S. K., Yang, K.-Y., Koh, J. S. B., Wong, M. K., Chua, S., Chua, D. T. C., & Howe, T. S. (2007) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.89b3.18146 · Cited by 510 · see citing works
Atypical Fractures of the Femoral Diaphysis in Postmenopausal Women Taking Alendronate
Lenart, B. A., Lorich, D. G., & Lane, J. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmc0707493 · Cited by 499 · see citing works
The mechanical consequences of variation in the mineral content of bone
Currey, J. D. (1969) · Journal of Biomechanics · doi:10.1016/0021-9290(69)90036-0 · Cited by 454 · see citing works
Kwek, E. B. K., Goh, S. K., Koh, J. S. B., Png, M. A., & Howe, T. S. (2008) · Injury · doi:10.1016/j.injury.2007.08.036 · Cited by 443 · see citing works
Abrahamsen, B., Eiken, P., & Eastell, R. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081247 · Cited by 363 · see citing works
Effects of differences in mineralization on the mechanical properties of bone
Currey, J. D. (1984) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1984.0042 · Cited by 352 · see citing works
Keaveny, T. M., Wachtel, E. F., Ford, C. M., & Hayes, W. C. (1994) · Journal of Biomechanics · doi:10.1016/0021-9290(94)90054-x · Cited by 330 · see citing works
Cortical and Trabecular Load Sharing in the Human Vertebral Body
Eswaran, S. K., Gupta, A. K., Adams, M. F., & Keaveny, T. M. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2006.21.2.307 · Cited by 308 · see citing works
Meunier, P. J., & Boivin, G. (1997) · Bone · doi:10.1016/s8756-3282(97)00170-1 · Cited by 299 · see citing works
Burr, D. B., Hirano, T., Turner, C. H., Hotchkiss, C. E., Brommage, R., & Hock, J. M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.1.157 · Cited by 295 · see citing works
(BONE), F. T. O. I. O. V. F. T. I. N. A. A. E., Delmas, P. D., Recker, R. R., Chesnut, C. H., Skag, A., Stakkestad, J. A., Emkey, R. D., Gilbride, J., Schimmer, R. C., & Christiansen, C. (2004) · Osteoporosis International · doi:10.1007/s00198-004-1602-9 · Cited by 278 · see citing works
Constant mineralization density distribution in cancellous human bone
Roschger, P., Gupta, H. S., Berzlanovich, A. M., Ittner, G., Dempster, D. W., Fratzl, P., Cosman, F., Parisien, M. V., Lindsay, R., Nieves, J. W., et al. (2003) · Bone · doi:10.1016/s8756-3282(02)00973-0 · Cited by 273 · see citing works
Severely Suppressed Bone Turnover and Atypical Skeletal Fragility
Visekruna, M., Wilson, D., & McKiernan, F. E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2803 · Cited by 267 · see citing works
Ensrud, K. E. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.157.22.2617 · Cited by 263 · see citing works
Riggs, B. L., & Melton, L. J. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.11 · Cited by 248 · see citing works
Elastic modulus and stress–strain response of human enamel by nano-indentation
He, L., Fujisawa, N., & Swain, M. V. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.03.045 · Cited by 227 · see citing works
Measurement of the toughness of bone: A tutorial with special reference to small animal studies
Ritchie, R. O., Koester, K. J., Ionova-Martin, S. S., Yao, W., Lane, N. E., & Ager, J. W. (2008) · Bone · doi:10.1016/j.bone.2008.04.027 · Cited by 224 · see citing works
An Application of Nanoindentation Technique to Measure Bone Tissue Lamellae Properties
Hoffler, C. E., Guo, X. E., Zysset, P. K., & Goldstein, S. A. (2005) · Journal of Biomechanical Engineering · doi:10.1115/1.2073671 · Cited by 222 · see citing works
Tang, S. Y., Allen, M. R., Phipps, R. J., Burr, D. B., & Vashishth, D. (2008) · Osteoporosis International · doi:10.1007/s00198-008-0754-4 · Cited by 217 · see citing works
&NA; (2001) · Southern Medical Journal · doi:10.1097/00007611-200106000-00005 · Cited by 217 · see citing works
Evaluation of a new modulus mapping technique to investigate microstructural features of human teeth
Balooch, G., Marshall, G. W., Marshall, S. J., Warren, O. L., Asif, S. A. S., & Balooch, M. (2004) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2003.12.012 · Cited by 206 · see citing works
Trreatment With Alendronate Prevents Fractures in Women at Highest Risk
Ensrud, K. E. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440430099012 · Cited by 182 · see citing works
Ladd, A. J. C., Kinney, J. H., Haupt, D. L., & Goldstein, S. A. (1998) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100160516 · Cited by 171 · see citing works
Borah, B., Dufresne, T. E., Ritman, E. L., Jorgensen, S. M., Liu, S., Chmielewski, P. A., Phipps, R. J., Zhou, X., Sibonga, J. D., & Turner, R. T. (2006) · Bone · doi:10.1016/j.bone.2006.01.161 · Cited by 153 · see citing works
Allen, M. R., & Burr, D. B. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070720 · Cited by 146 · see citing works
Bone histomorphometry: Proposed system for standardization of nomenclature, symbols, and units
PARFITT, A. M. (1988) · Calcified Tissue International · doi:10.1007/bf02556360 · Cited by 141 · see citing works
Bone quality: what is it and how is it measured?
Compston, J. E. (2006) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302006000400003 · Cited by 139 · see citing works
Perspective: Reconsidering the Effects of Antiresorptive Therapies in Reducing Osteoporotic Fracture
Chesnut, C. H., & Rosen, C. J. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.12.2163 · Cited by 130 · see citing works
Borah, B., Ritman, E. L., Dufresne, T. E., Jorgensen, S. M., Liu, S., Sacha, J. P., Phipps, R. J., & Turner, R. T. (2005) · Bone · doi:10.1016/j.bone.2005.03.017 · Cited by 130 · see citing works
Hvid, I., Bentzen, S. M., Linde, F., Mosekilde, L., & Pongsoipetch, B. (1989) · Journal of Biomechanics · doi:10.1016/0021-9290(89)90067-5 · Cited by 128 · see citing works
Yao, W., Cheng, Z., Pham, A., Busse, C., Zimmermann, E. A., Ritchie, R. O., & Lane, N. E. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23954 · Cited by 128 · see citing works
Yield Behavior of Bovine Cancellous Bone
Turner, C. H. (1989) · Journal of Biomechanical Engineering · doi:10.1115/1.3168375 · Cited by 127 · cited 1× · see citing works
“Although the volumetric bone density, which is not traditionally measured in clinical studies, is highly correlated with bone strength and strains [15] [16] [17] [18], recent studies have suggested that changes in bone quality, in addition to bone quantity, may also exert effects on fracture risk…”
Komatsubara, S., Mori, S., Mashiba, T., Ito, M., Li, J., Kaji, Y., Akiyama, T., Miyamoto, K., Cao, Y., Kawanishi, J., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.3.512 · Cited by 119 · see citing works
Zhang, J., Niebur, G. L., & Ovaert, T. C. (2007) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2007.09.019 · Cited by 109 · see citing works
Smith, S. Y., Recker, R. R., Hannan, M. T., Müller, R., & Bauss, F. (2003) · Bone · doi:10.1016/s8756-3282(02)00923-7 · Cited by 104 · see citing works
Verhulp, E. E., van Rietbergen, B., Müller, R., & Huiskes, R. (2008) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2008.02.032 · Cited by 99 · see citing works
Delmas, P. D., McClung, M. R., Zanchetta, J., Racewicz, A. J., Roux, C., Benhamou, C.-L., Man, Z., Eusebio, R. A., Beary, J. F., Burgio, D. E., et al. (2007) · Bone · doi:10.1016/j.bone.2007.09.001 · Cited by 96 · see citing works
Lewiecki, E. M., Keaveny, T. M., Kopperdahl, D. L., Genant, H. K., Engelke, K., Fuerst, T. P., Kivitz, A., Davies, R. Y., & Fitzpatrick, L. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1807 · Cited by 95 · see citing works
Ensrud, K. E., Black, D. M., Palermo, L., Bauer, D. C., Barrett-Connor, E. L., Quandt, S. A., Thompson, D. E., & Karpf, D. B. (1997) · PubMed · Cited by 93 · see citing works
Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice
Akhter, M. P., Cullen, D. M., Gong, G., & Recker, R. R. (2001) · Bone · doi:10.1016/s8756-3282(01)00486-0 · Cited by 88 · see citing works
Bauss, F., Lalla, S., Endele, R., & Hothorn, L. A. (2002) · PubMed · Cited by 86 · see citing works
How can bone turnover modify bone strength independent of bone mass?
Hernandez, C. J. (2008) · Bone · doi:10.1016/j.bone.2008.02.001 · Cited by 79 · see citing works
Monthly dosing of 75 mg risedronate on 2 consecutive days a month: efficacy and safety results
Delmas, P. D., Benhamou, C. L., Man, Z., Tłustochowicz, W., Matzkin, E., Eusebio, R. A., Zanchetta, J., Olszynski, W. P., Recker, R. R., & McClung, M. R. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0531-9 · Cited by 66 · see citing works
Variability of the mechanical properties of bone, and its evolutionary consequences
Currey, J. D., Pitchford, J. W., & Baxter, P. D. (2006) · Journal of The Royal Society Interface · doi:10.1098/rsif.2006.0166 · Cited by 49 · see citing works
Fuchs, R. K., Phipps, R. J., & Burr, D. B. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080501 · Cited by 48 · see citing works
Cheng, Z., Yao, W., Zimmermann, E. A., Busse, C., Ritchie, R. O., & Lane, N. E. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.81005 · Cited by 40 · see citing works
Determinants of skeletal fragility and bone quality.
Ch, T. (2002) · PubMed · Cited by 36 · see citing works
Mechanical analysis of bone and its microarchitecture based on in vivo voxel images
Ulrich, D., van Rietbergen, B., Laib, A., & Ruegsegger, P. (1998) · Technology and Health Care · doi:10.3233/thc-1998-65-614 · Cited by 34 · see citing works
Greiner, W. (1983) · Nuclear Physics A · doi:10.1016/0375-9474(83)90702-9 · Cited by 25 · see citing works
Mechanical analysis of bone and its microarchitecture based on in vivo voxel images
UlrichD., RietbergenB., LaibA., & RüegseggerP. (1998) · Technology and Health Care · doi:10.5555/307190.307254 · Cited by 21 · see citing works
Bisphosphonate Osteonecrosis (BON): Unanswered Questions and Research Possibilities
Migliorati, C. A., Schubert, M., & Peterson, D. E. (2009) · Reviews on Recent Clinical Trials · doi:10.2174/157488709788185978 · Cited by 13 · see citing works
Hooper, M. J., Faustino, A., Reid, I. R., Hosking, D. J., Gilchrist, N. L., Selby, P. L., Wu, M., Salzmann, G., West, J. A., & LEUNG, A. T. (2008) · Osteoporosis International · doi:10.1007/s00198-008-0639-6 · Cited by 8 · see citing works
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- [42]Cheng Z Yao W Zimmermann EA Busse C Ritchie RO Lane NE 2008 Prolonged Treatments with Anti-Resorptive Agents and PTH Have Different Effects on Bone Strength and the Degree of Mineralization in Old Estrogen Deficient Osteoporotic Rats J Bone Miner Res PMC3276355 18847326
Cited by
Sorted by citations
Allen, M. R., & Burr, D. B. (2011) · Bone · doi:10.1016/j.bone.2010.10.159 · Cited by 219 · see citing works
Bisphosphonates and bone quality
Pazianas, M., van der Geest, S. A. P., & Miller, P. D. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2014.24 · Cited by 84 · see citing works
Goonoo, N., & Bhaw‐Luximon, A. (2019) · RSC Advances · doi:10.1039/c9ra02765c · Cited by 66 · see citing works
Nicolaou, N., Agrawal, Y., Padman, M., Fernandes, J. A., & Bell, M. J. (2012) · Journal of Children s Orthopaedics · doi:10.1007/s11832-011-0380-0 · Cited by 56 · see citing works
Ozasa, R., Ishimoto, T., Miyabe, S., Hashimoto, J., Hirao, M., Yoshikawa, H., & Nakano, T. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0508-z · Cited by 53 · see citing works
Sub-sized short bend beam configuration for the study of mixed-mode fracture
Aliha, M. R. M., & Samareh‐Mousavi, S. S. (2019) · Engineering Fracture Mechanics · doi:10.1016/j.engfracmech.2019.106830 · Cited by 49 · see citing works
Santhosh, S., Mukherjee, D., Anbu, J., Murahari, M., & Teja, B. V. (2019) · Journal of Microencapsulation · doi:10.1080/02652048.2019.1631401 · Cited by 42 · see citing works
Prisby, R. D., Dominguez, J. M., Muller‐Delp, J. M., Allen, M. R., & Delp, M. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048564 · Cited by 40 · see citing works
Zhou, J. M., Liao, Y., Xie, H., Liao, Y., Zeng, Y., Li, N., Sun, G., Wu, Q., & Zhou, G. (2016) · Bioelectromagnetics · doi:10.1002/bem.22012 · Cited by 39 · see citing works
Atypical femur fractures: a review of the evidence and its implication to clinical practice
Girgis, C. M., & Seibel, M. J. (2011) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x11416270 · Cited by 35 · see citing works
Determinants of the mechanical behavior of human lumbar vertebrae after simulated mild fracture
Wegrzyn, J., Roux, J.-P., ARLOT, M. E., Boutroy, S., Vilayphiou, N., Guyen, O., Delmas, P. D., Chapurlat, R. D., & Bouxsein, M. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.264 · Cited by 34 · see citing works
Vuorimies, I., Mäyränpää, M. K., Valta, H., Kröger, H., Toiviainen‐Salo, S., & Mäkitie, O. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3745 · Cited by 31 · see citing works
Prevention of glucocorticoid induced bone changes with beta-ecdysone
Dai, W., Jiang, L., Lay, Y.-A. E., Chen, H., Jin, G., Zhang, H., Kot, A., Ritchie, R. O., Lane, N. E., & Yao, W. (2015) · Bone · doi:10.1016/j.bone.2015.01.001 · Cited by 30 · see citing works
Amugongo, S. K., Yao, W., Jia, J., Dai, W., Lay, Y.-A. E., Jiang, L., Harvey, D. J., Zimmermann, E. A., Schaible, E. G., Dave, N. K. N., et al. (2014) · Bone · doi:10.1016/j.bone.2014.04.033 · Cited by 26 · see citing works
Brennan, O., Kennedy, O. D., Lee, T. C., Rackard, S. M., O’Brien, F. J., & McNamara, L. M. (2010) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2010.10.023 · Cited by 26 · see citing works
Portner, J. A., & Johnson, J. A. (2010) · PubMed · Cited by 23 · see citing works
Massie, C. M., Knapp, E. K., Chen, K., Berger, A. J., & Awad, H. A. (2021) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2021.110243 · Cited by 21 · see citing works
Shahnazari, M., Yao, W., Wang, B., Panganiban, B., Ritchie, R. O., Hagar, Y., & Lane, N. E. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.249 · Cited by 20 · see citing works
Chen, H., Wu, M., & Kubo, K. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.04.017 · Cited by 19 · see citing works
Jia, J., Yao, W., Amugongo, S. K., Shahnazari, M., Dai, W., Lay, Y.-A. E., Olvera, D., Zimmermann, E. A., Ritchie, R. O., Li, C., et al. (2012) · Bone · doi:10.1016/j.bone.2012.10.017 · Cited by 19 · see citing works
Administration of Sodium Ibandronate in the Treatment of Complicated Giant Cell Tumor of the Spine
Zhang, W., Zhang, Y., Li, P., Rhodesm, S. D., Wang, Y., Xue, X., Dong, Y., Ding, W., Shen, Y., & Zhang, B. (2011) · Spine · doi:10.1097/brs.0b013e3182127f91 · Cited by 19 · see citing works
Krause, M., Soltau, Zimmermann, E., Hahn, M. P., Kornet, J. J., Hapfelmeier, A., Breer, S., Morlock, M. M., Wulff, B., Püschel, K., et al. (2014) · European Cells and Materials · doi:10.22203/ecm.v028a12 · Cited by 18 · see citing works
Stern, A. R., Yao, X., Wang, Y., Berhe, A., Dallas, M., Johnson, M. L., Yao, W., Kimmel, D. B., & Lane, N. E. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.02.005 · Cited by 17 · see citing works
The BALB/c mouse as a preclinical model of the age-related deterioration in the lumbar vertebra
Harris, D., Garrett, K., Uppuganti, S., Creecy, A., & Nyman, J. S. (2020) · Bone · doi:10.1016/j.bone.2020.115438 · Cited by 17 · see citing works
Localized sclerotic bone response demonstrated reduced nanomechanical creep properties
Chen, X., Goh, J. C., Teoh, S. H., De, S. D., Soong, R., & Lee, T. (2012) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2012.09.002 · Cited by 11 · see citing works
On the Evolution and Contemporary Roles of Bone Remodeling
Kostenuik, P. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00037-6 · Cited by 11 · see citing works
Bone Biomechanics and Bone Quality: Effects of Pharmaceutical Agents Used to Treat Osteoporosis
Burr, D. B. (2016) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-016-9217-1 · Cited by 10 · see citing works
Koth, V. S., Salum, F. G., de Figueiredo, M. A. Z., & Cherubini, K. (2020) · Clinical Oral Investigations · doi:10.1007/s00784-020-03585-x · Cited by 10 · see citing works
Matsuo, A., Hamada, H., Kaise, H., Chikazu, D., Yamada, K., & Kohno, N. (2014) · Acta Odontologica Scandinavica · doi:10.3109/00016357.2014.887772 · Cited by 9 · see citing works
Smith, E. R., & Allen, M. R. (2013) · Journal of Orthopaedic Research® · doi:10.1002/jor.22343 · Cited by 9 · see citing works
Effects of Drugs on Bone Quality
Imbert, L., & Boskey, A. L. (2016) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-016-9220-6 · Cited by 8 · see citing works
Iwamoto, J., & Seki, A. (2015) · Calcified Tissue International · doi:10.1007/s00223-015-0006-5 · Cited by 7 · see citing works
Boche, M., & Pokharkar, V. (2018) · Drug Delivery and Translational Research · doi:10.1007/s13346-018-0558-9 · Cited by 7 · see citing works
Bartlow, C. M., Oest, M. E., Mann, K. A., Zimmerman, N. D., Butt, B. B., & Damron, T. A. (2016) · Journal of Orthopaedic Research® · doi:10.1002/jor.23442 · Cited by 6 · see citing works
Radiation-induced changes in load-sharing and structure-function behavior in murine lumbar vertebrae
Wu, T., Bonnheim, N. B., Pendleton, M. M., Emerzian, S. R., & Keaveny, T. M. (2023) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/10255842.2023.2239415 · Cited by 5 · see citing works
Makowski, A. J., Granke, M., Uppuganti, S., Mahadevan-Jansen, A. M., & Nyman, J. S. (2015) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2080350 · Cited by 5 · see citing works
Hunckler, M. D., Chu, E. D., Baumann, A. P., Curtis, T. E., Ravosa, M. J., Allen, M. R., & Roeder, R. K. (2017) · Bone · doi:10.1016/j.bone.2017.08.015 · Cited by 5 · see citing works
Camacho‐Alonso, F., López‐Jornet, P., & Vicente, A. (2013) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.18449 · Cited by 5 · see citing works
Bone Evaluation with Micro Finite Element Analysis in Animal Models
Namiranian, B., Doi, K., Alenezi, S., Shah, S. B., Jerban, S., & Chang, E. (2025) · Tomography · doi:10.3390/tomography11090101 · Cited by 4 · see citing works
On the evolution and contemporary roles of bone remodeling
Kostenuik, P. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00031-9 · Cited by 2 · see citing works
Çağlar, S., Daşcı, M. F., Acar, A., Çağlar, A., Dinçel, Y. M., & Çataltepe, A. (2023) · Joint Diseases and Related Surgery · doi:10.52312/jdrs.2023.1096 · Cited by 2 · see citing works
Inselman, A. L., Masters, E. A., Moore, J., Agarwal, R., Gassman, A., Kuijpers, G. A. J., Beger, R. D., Delclos, K. B., Swift, S., Camacho, L., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1365151 · Cited by 2 · see citing works
Mouse Lumbar Vertebra Uniaxial Compression Testing with Embedding of the Loading Surface
Sparks, C. A., Ansaf, R. B., & Gabaldón, A. M. (2023) · Journal of Visualized Experiments · doi:10.3791/65502 · Cited by 1 · see citing works
Schumacher, Y. (2013) · QSpace (Queen's University Library) · Cited by 1 · see citing works
Bisphosphonate treatment in children with osteogenesis imperfecta: benefits and concerns
Vuorimies, I. (2017) · Työväentutkimus Vuosikirja
Sparks, C. A., Ansaf, R. B., & Gabaldón, A. M. (2023) · doi:10.3791/65502-v
Aguirre, J. I., Messer, J. G., Castillo, E. J., Gomes, T. L. D. S. F., Urrego, C. A., Kohn, D. H., & Kimmel, D. B. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1772372
- Authors
- Shahnazari, M., Yao, W., Dai, W., Wang, B., Ionova-Martin, S. S., Ritchie, R. O., Heeren, D., Burghardt, A. J., Nicolella, D. P., Kimiecik, M. G., & Lane, N. E.
- Affiliations
- University of California Davis Medical Center (US)
- Lawrence Berkeley National Laboratory (US)
- University of California, San Francisco (US)
- Southwest Research Institute (US)
- Corresponding author
- Lane, Nancy E.
- Venue
- Bone
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 46
- Issue
- 5
- Pages
- 1267-1274
- ISSN
- 1873-2763 (ISSN-L)
- 8756-3282
- PMC
- PMC3003226
- OpenAlex
- W2039496643
- Cited by
- 46
- References
- 67
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Bone (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AR043052-07, AR-048841, 1K12HD05195801)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- bisphosphonates, ibandronate, risedronate, dose-response relationship, bone quality, bone mass, bone microarchitecture, bone mineralization, bone strength, fracture toughness, elastic modulus, trabecular bone, cortical bone, osteopenia, ovariectomy, aging, vertebral biomechanics, finite element analysis, lumbar vertebrae
- MeSH terms
- Aging, Animals, Bone and Bones, Bone Diseases, Metabolic, Diphosphonates, Female, Lumbar Vertebrae, Ovariectomy, Rats, Inbred F344, Compressive Strength, Finite Element Analysis, Bone Density Conservation Agents, Rats
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