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Cited by 227Mitochondrial Function and PathologyDiet and metabolism studiesNeuroscience and Neuropharmacology Research

Fatty Acids in Energy Metabolism of the Central Nervous System

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Panov, Alexander, Orynbayeva, Zulfiya, Vavilin, Valentin, Lyakhovich, Vyacheslav·2014·BioMed Research International
DOI 10.1155/2014/472459PMC PMC4026875
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Abstract

In this review, we analyze the current hypotheses regarding energy metabolism in the neurons and astroglia. Recently, it was shown that up to 20% of the total brain’s energy is provided by mitochondrial oxidation of fatty acids. However, the existing hypotheses consider glucose, or its derivative lactate, as the only main energy substrate for the brain. Astroglia metabolically supports the neurons by providing lactate as a substrate for neuronal mitochondria. In addition, a significant amount of neuromediators, glutamate and GABA, is transported into neurons and also serves as substrates for mitochondria. Thus, neuronal mitochondria may simultaneously oxidize several substrates. Astrocytes have to replenish the pool of neuromediators by synthesis de novo, which requires large amounts of energy. In this review, we made an attempt to reconcileβ-oxidation of fatty acids by astrocytic mitochondria with the existing hypothesis on regulation of aerobic glycolysis. We suggest that, under condition of neuronal excitation, both metabolic pathways may exist simultaneously. We provide experimental evidence that isolated neuronal mitochondria may oxidize palmitoyl carnitine in the presence of other mitochondrial substrates. We also suggest that variations in the brain mitochondrial metabolic phenotype may be associated with different mtDNA haplogroups.

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  • The brain alone consumes 20% of the total energy required by the body, and central nervous system mitochondria meet a majority of this massive energy requirement for the brain.

    “The brain alone consumes 20% of the total energy required by the body, and central nervous system (CNS) mitochondria meet a majority of this massive energy requirement for the brain”

    From Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism (2026) · cites this paper as Panov et al. 2014

    Section 4 says brain functions depend on aerobic mitochondrial energy metabolism, supporting the claim that mitochondria meet much of the brain’s energy needs. But the paper does not say the brain consumes 20% of the body’s energy. Its 20% figure, in Section 5, refers instead to the share of the adult brain’s energy supplied by fatty-acid oxidation; page numbers are unavailable in our copy. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Panov, A., Orynbayeva, Z., Vavilin, V., & Lyakhovich, V.
Affiliations
  • Institute of Molecular Biology and Biophysics (RU)
  • Drexel University (US)
  • Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences (SB RAMS), 2 Timakova st., Novosibirsk 630117, Russia
Corresponding author
Panov, Alexander
ORCID
Venue
BioMed Research International
Publisher
Wiley
Published
2014
Volume
2014
Pages
1-22
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
DOI
10.1155/2014/472459
PMC
PMC4026875
OpenAlex
W2160164968
Cited by
227
References
8
Citations by year
2026: 14 · 2025: 30 · 2024: 29 · 2023: 22 · 2022: 19 · 2021: 27 · 2020: 22 · 2019: 21 · 2018: 8 · 2017: 14 · 2016: 11 · 2015: 8 · 2014: 2
FWCI
1.10
Type
journal article
Language
en
Open access
Licence
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
fatty acid oxidation, brain energy metabolism, mitochondrial beta-oxidation, astrocytes, neurons, aerobic glycolysis, lactate, glutamate, GABA, neuromediators, palmitoylcarnitine, mtDNA haplogroups, neuronal excitation
MeSH terms
Astrocytes, Brain, Central Nervous System, Energy Metabolism, Fatty Acids, Mitochondria, Neurons, Oxidation-Reduction, Lactic Acid

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