Cited by 81Dietary Effects on HealthDiet, Metabolism, and DiseaseCircadian rhythm and melatonin

Effects of meal timing on postprandial glucose metabolism and blood metabolites in healthy adults

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Takahashi, Masaki, Ozaki, Mamiho, Kang, Moon-Il, Sasaki, Hiroyuki, Fukazawa, Mayuko, Iwakami, Tamao, Lim, Pei Jean, Kim, Hyeon-Ki +2 more·2018·Nutrients

Abstract

We examined the effects of meal timing on postprandial glucose metabolism, including the incretin response and metabolites in healthy adults. Nineteen healthy young men completed two trials involving blood collection in a fasting state and at 30, 60 and 120 min after meal provision in a random order: (1) morning (~0900 h) and (2) evening (~1700 h). The blood metabolome of eight participants was analyzed using capillary electrophoresis-mass spectrometry. Postprandial glucose concentrations at 120 min (p = 0.030) and glucose-dependent insulinotropic polypeptide concentrations (p = 0.005) at 60 min in the evening trials were higher than those in the morning trials. The incremental area under the curve values of five glycolysis, tricarboxylic acid cycle and nucleotide-related metabolites and 18 amino acid-related metabolites were higher in the morning trials than those in the evening trials (p < 0.05). Partial least-squares analysis revealed that the total metabolic change was higher in the morning. Our study demonstrates that a meal in the evening exacerbates the state of postprandial hyperglycemia in healthy adults. In addition, this study provides insight into the difference of incretion and blood metabolites between breakfast and dinner, indicating that the total metabolic responses tends to be higher in the morning.

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  • Medical research suggests that the effects of the postprandial dip peak approximately thirty to sixty minutes after meals.

    “Medical research suggests that the effects of the postprandial dip peak approximately thirty to sixty minutes after meals (Alleman Jr and Bloomer, 2011; Takahashi et al., 2018).”

    From Food Coma is Real: The Effect of Digestive Fatigue on Adolescents' Cognitive Performance (2024) · cites this paper as Takahashi et al., 2018

    The Abstract describes blood measurements at 30, 60, and 120 minutes after meals, while the Discussion addresses glucose and incretin responses. Neither section says that a postprandial dip peaks 30–60 minutes after a meal; searches for the dip and for related sleepiness or alertness found no such passage. Page numbers were not available in our copy. (LLM, conf=0.76)

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Research works printed but not linked: 1

  1. [1]European Diabetes Epidemiology Group Diabetes Epidemiology: Collaborative analysis of diagnostic criteria in Europe Lancet 1999 354 617 621 10466661

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Authors
Takahashi, M., Ozaki, M., Kang, M.-I., Sasaki, H., Fukazawa, M., Iwakami, T., Lim, P. J., Kim, H.-K., Aoyama, S., & Shibata, S.
Affiliations
  • Waseda University (JP)
  • Human Metabolome Technologies, Inc. (Japan) (JP)
Corresponding author
Takahashi, Masaki
Venue
Nutrients
Publisher
MDPI AG
Published
2018-11-14
Volume
10
Issue
11
Pages
1763
ISSN
2072-6643 (ISSN-L)
OpenAlex
W2901042565
Cited by
81
References
52
Citations by year
2026: 11 · 2025: 9 · 2024: 10 · 2023: 13 · 2022: 11 · 2021: 9 · 2020: 16 · 2019: 2
FWCI
4.64
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
KAKENHI Grant (26220201)
Topics
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
meal timing, postprandial glucose metabolism, postprandial hyperglycemia, incretin response, glucose-dependent insulinotropic polypeptide, blood metabolome, glycolysis metabolites, tricarboxylic acid cycle metabolites, amino acid metabolites, circadian rhythm, healthy young men
MeSH terms
Adult, Blood Glucose, Gastric Inhibitory Polypeptide, Glucose, Humans, Insulin, Male, Cross-Over Studies, Postprandial Period, Glucagon-Like Peptide 1, Young Adult, Meals

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