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Cited by 140Diabetes, Cardiovascular Risks, and LipoproteinsHormonal and reproductive studiesAdipokines, Inflammation, and Metabolic Diseases

The relationship of sex hormones to hyperinsulinemia and hyperglycemia

Haffner, Steven M., Katz, Michael S., Stern, Michael P., Dunn, James F.·1988·Metabolism
DOI 10.1016/0026-0495(88)90091-1
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Abstract

Mexican-Americans, a high-risk population for non-insulin-dependent diabetes mellitus (NIDDM), have been previously reported to have decreased levels of sex-hormone-binding globulin (SHBG). We measured total testosterone, total estradiol and SHBG, glucose and insulin in premenopausal women (58 Mexican-Americans and 38 non-Hispanic whites) as part of the San Antonio Heart Study, a population-based study of cardiovascular risk factors. Although total estradiol and total testosterone were, in general, not correlated with metabolic variables, SHBG was negatively correlated with glucose and insulin. After adjustment for body mass index (BMI), ratio of waist-to-hip circumference (WHR) and ratio of subscapular-to-triceps skinfold (Centrality Index), SHBG was still significantly correlated with insulin concentrations (P less than .001). Since Mexican-Americans were previously reported to be more hyperinsulinemic than non-Hispanic whites, we examined the effect of adjusting for SHBG on insulin levels in this small population. While unadjusted insulin concentrations in Mexican-Americans were higher than in non-Hispanic whites (354 microU/mL v 236 microU/mL, respectively, P = .009), adjustment for BMI, WHR, and centrality index reduced the ethnic difference in insulin levels considerably (P = .014). However, only after adjusting for SHBG as well, did the ethnic difference in insulin levels became nonsignificant. Our data suggest that alterations in sex hormones and SHBG in particular ma…

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Authors
Haffner, S. M., Katz, M. S., Stern, M. P., & Dunn, J. F.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Corresponding author
Haffner, Steven M.
Venue
Metabolism
Publisher
Elsevier BV
Published
1988-07
Volume
37
Issue
7
Pages
683-688
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(88)90091-1
OpenAlex
W2031566801
Cited by
140
References
1
Citations by year
2024: 1 · 2023: 5 · 2022: 3 · 2021: 3 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 3 · 2013: 2 · 2012: 5
FWCI
5.60
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL24799)
  • National Center for Research Resources (RR-01346)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
sex hormones, sex hormone-binding globulin, hyperinsulinemia, hyperglycemia, type 2 diabetes, Mexican Americans, testosterone, estradiol, ethnic differences, insulin resistance, body mass index, waist-to-hip ratio, skinfold thickness
MeSH terms
Adult, Blood Glucose, Diabetes Mellitus, Type 2, Estradiol, Female, Hispanic or Latino, Humans, Hyperglycemia, Hyperinsulinism, Insulin, Mexico, Middle Aged, Sex Hormone-Binding Globulin, Gonadal Steroid Hormones, Testosterone, White People

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