CoChat
Sign Up
Cited by 178Food composition and propertiesGut microbiota and healthMicrobial Metabolites in Food Biotechnology

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Carbohydrate fermentation decreases hepatic glucose output in healthy subjects

Thorburn, Anne, Muir, Jane, Proietto, Joseph·1993·Metabolism
DOI 10.1016/0026-0495(93)90249-n
Open this paper in CoChat — free account

Abstract

Fermentation of undigested carbohydrate produces short-chain fatty acids (SCFA), some of which have been shown to reduce hepatic glucose production (HGP) in animals. The aim of this study was to examine whether carbohydrate fermentation decreases HGP in man. Ten healthy subjects consumed 90-g carbohydrate portions of either brown rice or barley for dinner in random order 1 week apart. The following morning, glucose kinetics were measured basally and during an oral glucose tolerance test (OGTT). HGP was calculated as the difference between the total rate of glucose appearance (calculated from % enrichment of 6,6 dideuterated glucose [6,6 D2 glucose]) and the rate of appearance of gut-derived glucose (calculated from 6-3H glucose in the glucose drink). To detect fermentation, breath H2 content was measured by end-expiratory sampling of alveolar air. Significantly more breath H2 was produced after barley consumption (24 +/- 4 v 4 +/- 1 ppm, P < .001), indicating that barley contains more fermentable carbohydrate than rice. Glucose tolerance improved after the barley meal, with the peak OGTT plasma glucose concentration being 0.7 mmol/L lower than that after the rice meal (7.7 +/- 0.4 v 8.4 +/- 0.3 mmol/L, P < .05). This was primarily due to a 30% reduction in HGP (area under the curve, 909 +/- 116 v 1,295 +/- 157 mumol/kg; P < .01). No difference in the rates of glucose disappearance or gut glucose absorption was observed. However, serum free fatty acid (FFA) concentrations were…

Overview

Integrity signals

Registry

Crossref · 10.1016/0026-0495(93)90249-n

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 40 references

Research works printed but not linked: 1

  1. O'Dea, 1990, Factors influencing carbohydrate digestion: Acute and long-term consequences, Diabetes Nutr Metab, 3, 251

Cited by

Sorted by citations

Items 101–177 of 177

Related

See all

Metadata

Authors
Thorburn, A., Muir, J., & Proietto, J.
Affiliations
The Royal Melbourne Hospital (AU)
Corresponding author
Thorburn, Anne
ORCID
Muir, Jane
Venue
Metabolism
Publisher
Elsevier BV
Published
1993-06
Volume
42
Issue
6
Pages
780-785
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(93)90249-n
OpenAlex
W2043515140
Cited by
178
References
40
Citations by year
2025: 1 · 2024: 4 · 2023: 2 · 2021: 6 · 2020: 6 · 2019: 1 · 2018: 6 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 9 · 2012: 5
FWCI
5.06
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Health and Medical Research Council
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
carbohydrate fermentation, hepatic glucose production, short-chain fatty acids, barley, brown rice, breath hydrogen, glucose tolerance, free fatty acids, oral glucose tolerance test
MeSH terms
Adult, Analysis of Variance, Hordeum, Blood Glucose, Dietary Carbohydrates, Female, Fermentation, Glucose, Glucose Tolerance Test, Humans, Liver, Male, Reference Values, Oryza, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review