CoChat
Sign Up
Cited by 20Adrenal Hormones and DisordersStress Responses and CortisolDiabetes Management and Research

Adrenal steroid and adrenocorticotropin responses to human corticotropin-releasing hormone stimulation test in adolescents with type I diabetes mellitus

Ghizzoni, Lucia, Vanelli, Maurizio, Virdis, Raffaele, Alberini, Angela, Volta, Cecilia, Bernasconi, Sergio·1993·Metabolism
DOI 10.1016/0026-0495(93)90271-o
Open this paper in CoChat — free account

Abstract

To determine whether abnormalities of hypothalamic-pituitary-adrenal axis function occur in type I diabetes mellitus, corticotropin, cortisol, 17-hydroxyprogesterone (17-OHP), androstenedione (D4-A), dehydroepiandrosterone (DHEA), and DHEA sulfate (DS) levels were measured after an intravenous (IV) injection of 1 microgram/kg human corticotropin-releasing hormone (CRH) in diabetic adolescents and normal age-matched subjects. CRH produced a consistent increase in corticotropin blood levels that was comparable in the two groups. In contrast, both baseline and stimulated cortisol concentrations were greater in diabetic patients. Levels of 17-OHP increased after CRH administration, and the magnitude of increase was similar in all subjects. Stimulation with CRH determined an attenuated integrated DS response in diabetics compared with normal subjects with a different pattern of the hormone secretion, whereas no differences in D4-A concentrations were detected between the two groups. DHEA serum levels of subjects from both groups underwent similar changes following administration of CRH. In conclusion, patients with type I diabetes have a discrete response of adrenal steroids to CRH stimulation that appears to be independent of corticotropin secretion. This phenomenon might be related to a direct effect of insulin on enzyme systems involved in the biosynthetic pathway of adrenal steroids or, alternatively, to an intra-adrenal CRH/corticotropin mechanism acting on the adrenal cortex…

Integrity signals

Registry

Crossref · 10.1016/0026-0495(93)90271-o

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Hyperactivity of the HPA axis and hyperinsulinemia are frequently observed in patients with type 1 and type 2 diabetes and in patients with abdominal adiposity.

    “Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis in association with hyperinsulinemia is frequently found in patients with type 1 and type 2 diabetes mellitus and in subjects with abdominal adiposity.”

    From Supraphysiological Hyperinsulinemia Acutely Increases Hypothalamic-Pituitary-Adrenal Secretory Activity in Humans (1999) · cites this paper as [3]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Ghizzoni, L., Vanelli, M., Virdis, R., Alberini, A., Volta, C., & Bernasconi, S.
Affiliations
University of Parma (IT)
Corresponding author
Ghizzoni, Lucia
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
1993-09
Volume
42
Issue
9
Pages
1141-1145
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(93)90271-o
OpenAlex
W2067437142
Cited by
20
References
34
Citations by year
2018: 1 · 2013: 2
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
type 1 diabetes, adolescents, hypothalamic-pituitary-adrenal axis, corticotropin-releasing hormone stimulation test, ACTH, cortisol, 17-hydroxyprogesterone, dehydroepiandrosterone sulfate, androstenedione, adrenal steroid secretion
MeSH terms
Adolescent, Adrenal Glands, Adrenocorticotropic Hormone, Corticotropin-Releasing Hormone, Diabetes Mellitus, Type 1, Hormones, Humans, Male, Osmolar Concentration, Reference Values

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review