Divergent correlations of circulating dehydroepiandrosterone sulfate and testosterone with insulin levels and insulin receptor binding.
Abstract
We evaluated the insulin response to a standard oral glucose tolerance test (OGTT) and in vitro insulin binding to erythrocytes (RBC) in 26 women from 3 groups: Group NW, normal women (n = 11); Group DS, women (n = 9) with elevated serum DHEAS concentrations, greater than 400 micrograms/dl (greater than 10.84 mumol/L); and Group IR, women (n = 6) with elevated basal plasma insulin concentrations (IRI). There was a significant linear correlation between the area under the insulin response curve (IRI-AUC) and serum testosterone (T) (r = 0.78, p = 0.0001). Using stepwise multiple linear regression, IRI-AUC was characterized as a function of both serum T and DHEAS; positively with T and negatively with DHEAS. In vitro (n = 17), there was a positive correlation between RBC-insulin binding and serum DHEAS (r = 0.54, p = 0.029) and a negative correlation between RBC-binding and T (r = -0.57, p = 0.017). We conclude that DHEAS may enhance insulin binding and action and that DHEAS and T have divergent functional relationships with IRI. DHEAS and T may therefore exert opposing effects on insulin secretion and action.
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As metformin can improve insulin sensitivity and adrenal cells have insulin receptors, insulin may have an impact on peripheral or adrenal tissue DHEAS metabolism.
“As metformin can improve insulin sensitivity and adrenal cells have insulin receptors [41], insulin may have an impact on peripheral or adrenal tissue DHEAS metabolism.”
From Efficacy of WeChat-Based Digital Intervention Versus Metformin in Women With Polycystic Ovary Syndrome: Randomized Controlled Trial (2024) · cites this paper as [41]
The 70-95% reduction in formation of DHEA and DHEA-S by the adrenals during aging results in a dramatic reduction in formation of androgens and estrogens in peripheral target tissues, which could be involved in pathogenesis of age-related diseases such as insulin resistance and obesity.
“The 70 -95% reduction in the formation of DHEA and DHEA-S by the adrenals during aging results in a dramatic reduction in the formation of androgens and estrogens in peripheral target tissues, which could well be involved in the pathogenesis of age-related diseases such as insulin resistance (307, 308) and obesity (309 -311).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [307]
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“As metformin can improve insulin sensitivity and adrenal cells have insulin receptors [41], insulin may have an impact on peripheral or adrenal tissue DHEAS metabolism.”
- Authors
- Schriock, E. D., Buffington, C. K., Hubert, G. D., Kurtz, B. R., Kitabchi, A. E., Buster, J. E., & Givens, J. R.
- Affiliations
- University of Tennessee Health Science Center (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1988-06
- Volume
- 66
- Issue
- 6
- Pages
- 1329-1331
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2136811987
- Cited by
- 115
- References
- 11
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 5
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- U.S. Public Health Service
- National Center for Research Resources (RR 00211)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- dehydroepiandrosterone sulfate, testosterone, insulin resistance, insulin secretion, insulin binding, erythrocytes, oral glucose tolerance test, women, insulin action
- MeSH terms
- Dehydroepiandrosterone, Erythrocytes, Female, Glucose Tolerance Test, Humans, Insulin, Radioimmunoassay, Receptor, Insulin, Regression Analysis, Testosterone, Dehydroepiandrosterone Sulfate
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