The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens
Abstract
The hypothesis that the dopaminergic system plays a role in feeding behavior was tested in three experiments. First, microdialysis was performed in the nucleus accumbens (NAC) at 20 min intervals during free feeding in rats at 80% of normal body weight. Extracellular concentration of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) increased significantly during eating indicating an increase in DA turnover. Second, microdialysis samples were collected from the NAC during bar pressing with a) a signal light on and food available, b) the light on but no food available, c) neither light nor food. Only when food was available did extracellular DA, DOPAC and HVA increase significantly. This increase in DA turnover occurred in the accumbens but not in the ventral striatum. Third, electrical stimulation of the perifornical lateral hypothalamus (LH) that was capable of inducing feeding increased extracellular DA, DOPAC and HVA in the NAC. This occurred whether the animal had food to eat or not. The effect of LH stimulation on DA turnover resembled the effects of free feeding and operant feeding in Experiments 1 and 2. Perifornical LH stimulation did not increase dopamine turnover in the ventral striatum. The results show that perifornical LH stimulation activates the mesolimbic dopamine system and that dopamine release in the accumbens is involved in feeding. The increase in dopamine turnover outlasted the consummatory act. This suggests that accumbens dopamine may be related to sensory input, feeding reflexes, food reward or memory processes and not just to the consummatory act itself.
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“Increased dopamine (DA) release in mesolimbic reward circuitry is associated with approach behaviors that promote survival.”
From Physiological feelings (2019) · cites this paper as Hernandez and Hoebel, 1988
In the citing paper
“For example, the presence of food triggers an increase in extracellular DA in the nucleus accumbens (Hernandez and Hoebel, 1988;Yoshida et al., 1992)”
From Physiological feelings (2019) · cites this paper as Hernandez and Hoebel, 1988
In the citing paper
“In addition, when palatable foods such as sucrose are actually consumed, a sustained and sweetness-dependent increase occurs in nucleus accumbens dopamine levels and turnover ([75](#B75), [80](#B80), [165](#B165)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [80]
Citations
Cites
Stereotaxic mapping of the monoamine pathways in the rat brain
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb10998.x · Cited by 3,819
Rowan, W., & Tinbergen, N. (1952) · Bird-Banding · doi:10.2307/4510368 · Cited by 2,706
Progress in Psychobiology and Physiological Psychology
Fluharty, S. J., & Grill, H. J. (2003) · Progress in psychobiology and physiological psychology · doi:10.1108/s0363-0951200318 · Cited by 1,701
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb11001.x · Cited by 1,294
Hypothalamic control of food intake in rats and cats.
Anand, B. K., & Brobeck, J. R. (1951) · PubMed · Cited by 1,197
Lindvall, O., & Björklund, A. (1974) · PubMed · Cited by 1,131
Herkenham, M. A., & Nauta, W. J. H. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901730107 · Cited by 798
Sensory Neglect Produced by Lateral Hypothalamic Damage
Marshall, J. F., Turner, B. H., & Teitelbaum, P. (1971) · Science · doi:10.1126/science.174.4008.523 · Cited by 411
Simon, H., Moal, M. L., & Calas, A. (1979) · Brain Research · doi:10.1016/0006-8993(79)90085-4 · Cited by 401
Hypothalamic Control of Feeding and Self-Stimulation
Hoebel, B. G., & Teitelbaum, P. (1962) · Science · doi:10.1126/science.135.3501.375 · Cited by 389
Self-citation
Research works printed but not linked: 3
- Brugger, 1943, Fresstrieb als hypothalamisches symptom, Helv. Physiol. Pharmacol. Acta, 1, 183
- Collier, 1983, Life in a closed economy: The ecology of learning and motivation, vol. 3
- Morgane, 1979, Historical and modern concepts of hypothalamic organization and function, vol. 1, 1
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Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450
Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward
Kelley, A. E., Baldo, B. A., Pratt, W. E., & Will, M. J. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.066 · Cited by 752
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
Zhou, Q.-Y., & Palmiter, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90145-0 · Cited by 731
Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632
Alcaro, A., Huber, R., & Panksepp, J. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.07.014 · Cited by 661
Metadata
- Authors
- Hernandez, L., & Hoebel, B. G.
- Affiliations
- Princeton University (US)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 44
- Issue
- 4-5
- Pages
- 599-606
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2066841804
- Cited by
- 355
- References
- 36
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 3 · 2022: 12 · 2021: 7 · 2020: 49 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 11 · 2014: 11 · 2013: 9 · 2012: 14
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA 03597)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- feeding behavior, dopamine turnover, nucleus accumbens, mesolimbic dopamine system, extracellular dopamine, dihydroxyphenylacetic acid, homovanillic acid, ventral striatum, food reward
- MeSH terms
- Animals, Body Weight, Corpus Striatum, Dopamine, Eating, Electric Stimulation, Female, Hunger, Hypothalamic Area, Lateral, Male, Neural Pathways, Nucleus Accumbens, Rats, Inbred Strains, Receptors, Dopamine, Septal Nuclei, Rats
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