Cited by 224Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityNeural and Behavioral Psychology Studies

Mesolimbic dopaminergic system activity as a function of food reward: a microdialysis study

Martel, P·1996·Pharmacology Biochemistry and Behavior

Abstract

The mesolimbic dopaminergic system (MDS) has been shown to be implicated in feeding behaviors. The present experiment was conducted to examine the effects of the sensory properties of food ingested on MDS activity. Microdialysis coupled to high-performance liquid chromatography with electrochemical detection was employed to measure the extracellular levels of dopamine (DA) and its main metabolites (DOPAC and HVA) in the nucleus accumbens of freely moving rats. During microdialysis sessions rats had access or not to powdered foods varying in palatability: short cakes as highly palatable (HP) food and regular chow as low palatable (LP) food. In the absence of food, there were no alterations in extracellular levels of DA, DOPAC, and HVA. During feeding, DA rose significantly with a greater rise for the HP than the LP food. Levels of DOPAC and HVA only reached significance with the HP food. The results indicate that the MDS is activated on ingestion of food, and suggest that MDS activity is related to the rewarding properties of foods.

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Crossref · 10.1016/0091-3057(95)00187-5

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  • In rodent studies, extracellular concentrations of dopamine and its metabolites in the nucleus accumbens increased more after consumption of highly palatable food than after standard rodent feed pellets.

    “In rodent studies, extracellular concentrations of dopamine and its metabolites in the nucleus accumbens increased more after the consumption of highly palatable food than standard rodent feed pellets (4).”

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Authors
Martel, P.
Affiliations
Université de Bourgogne (FR)
Corresponding author
Martel, P
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1996-01
Volume
53
Issue
1
Pages
221-226
ISSN
0091-3057 (ISSN-L)
OpenAlex
W1972178738
Cited by
224
References
48
Citations by year
2026: 3 · 2025: 3 · 2024: 1 · 2023: 6 · 2022: 3 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 9 · 2015: 5 · 2014: 9 · 2013: 11 · 2012: 15
FWCI
1.35
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
Conseil régional de Bourgogne-Franche-Comté
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
mesolimbic dopamine system, food reward, palatability, nucleus accumbens, dopamine, DOPAC, homovanillic acid, feeding behavior, extracellular dopamine, rats
MeSH terms
Animals, Dopamine, Food, Homovanillic Acid, Limbic System, Male, Nucleus Accumbens, Reward, 3,4-Dihydroxyphenylacetic Acid, Rats, Sprague-Dawley, Microdialysis, Rats

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