The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens
Abstract
The hypothesis that the dopaminergic system plays a role in feeding behavior was tested in three experiments. First, microdialysis was performed in the nucleus accumbens (NAC) at 20 min intervals during free feeding in rats at 80% of normal body weight. Extracellular concentration of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) increased significantly during eating indicating an increase in DA turnover. Second, microdialysis samples were collected from the NAC during bar pressing with a) a signal light on and food available, b) the light on but no food available, c) neither light nor food. Only when food was available did extracellular DA, DOPAC and HVA increase significantly. This increase in DA turnover occurred in the accumbens but not in the ventral striatum. Third, electrical stimulation of the perifornical lateral hypothalamus (LH) that was capable of inducing feeding increased extracellular DA, DOPAC and HVA in the NAC. This occurred whether the animal had food to eat or not. The effect of LH stimulation on DA turnover resembled the effects of free feeding and operant feeding in Experiments 1 and 2. Perifornical LH stimulation did not increase dopamine turnover in the ventral striatum. The results show that perifornical LH stimulation activates the mesolimbic dopamine system and that dopamine release in the accumbens is involved in feeding. The increase in dopamine turnover outlasted the consummatory act. This suggests that accumbens dopamine may be related to sensory input, feeding reflexes, food reward or memory processes and not just to the consummatory act itself.
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“Increased dopamine (DA) release in mesolimbic reward circuitry is associated with approach behaviors that promote survival.”
From Physiological feelings (2019) · cites this paper as Hernandez and Hoebel, 1988
In the citing paper
“For example, the presence of food triggers an increase in extracellular DA in the nucleus accumbens (Hernandez and Hoebel, 1988;Yoshida et al., 1992)”
From Physiological feelings (2019) · cites this paper as Hernandez and Hoebel, 1988
In the citing paper
“In addition, when palatable foods such as sucrose are actually consumed, a sustained and sweetness-dependent increase occurs in nucleus accumbens dopamine levels and turnover ([75](#B75), [80](#B80), [165](#B165)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [80]
Citations
Cites
Stereotaxic mapping of the monoamine pathways in the rat brain
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb10998.x · Cited by 3,819
Rowan, W., & Tinbergen, N. (1952) · Bird-Banding · doi:10.2307/4510368 · Cited by 2,706
Progress in Psychobiology and Physiological Psychology
Fluharty, S. J., & Grill, H. J. (2003) · Progress in psychobiology and physiological psychology · doi:10.1108/s0363-0951200318 · Cited by 1,701
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb11001.x · Cited by 1,294
Hypothalamic control of food intake in rats and cats.
Anand, B. K., & Brobeck, J. R. (1951) · PubMed · Cited by 1,197
Lindvall, O., & Björklund, A. (1974) · PubMed · Cited by 1,131
Herkenham, M. A., & Nauta, W. J. H. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901730107 · Cited by 798
Sensory Neglect Produced by Lateral Hypothalamic Damage
Marshall, J. F., Turner, B. H., & Teitelbaum, P. (1971) · Science · doi:10.1126/science.174.4008.523 · Cited by 411
Simon, H., Moal, M. L., & Calas, A. (1979) · Brain Research · doi:10.1016/0006-8993(79)90085-4 · Cited by 401
Hypothalamic Control of Feeding and Self-Stimulation
Hoebel, B. G., & Teitelbaum, P. (1962) · Science · doi:10.1126/science.135.3501.375 · Cited by 389
Self-citationSelf-injection of amphetamine directly into the brain
Hoebel, B. G., Monaco, A. P., Hernandez, L., Aulisi, E. F., Stanley, B. G., & Lenard, L. (1983) · Psychopharmacology · doi:10.1007/bf00429012 · Cited by 367
Self-citationRoth, R. H., Murrin, L. C., & Walters, J. R. (1976) · European Journal of Pharmacology · doi:10.1016/0014-2999(76)90268-5 · Cited by 364
Stricker, E., & Zigmond, M. (1976) · Cited by 356
THE FUNCTIONAL ORGANIZATION OF THE DIENCEPHALON
(1960) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1960.tb86933.x · Cited by 308
Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats
Zigmond, M. J., & Stricker, E. M. (1972) · Science · doi:10.1126/science.177.4055.1211 · Cited by 296
Conditioned place preference from intra-accumbens but not intra-caudate amphetamine injections
Carr, G. D., & White, N. M. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90165-0 · Cited by 275
The Functional Organization of the Diencephalon
Mettler, F. A. (1958) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-195810000-00017 · Cited by 248
Recovery from the Failure to Eat Produced by Hypothalamic Lesions
Teitelbaum, P., & Stellar, E. (1954) · Science · doi:10.1126/science.120.3126.894 · Cited by 216
A small, removable microdialysis probe
Hernandez, L., Stanley, B. G., & Hoebel, B. G. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90119-0 · Cited by 211
Self-citationBrainstem projections from the lateral hypothalamic area in the rat, as studied with autoradiography
Hosoya, Y., & Matsushita, M. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90232-9 · Cited by 210
Feeding Increases Dopamine Metabolism in the Rat Brain
Heffner, T. G., Hartman, J. A., & Seiden, L. S. (1980) · Science · doi:10.1126/science.7375926 · Cited by 206
Modification of Motivated Behavior Elicited by Electrical Stimulation of the Hypothalamus
Valenstein, E. S., Cox, V. C., & Kakolewski, J. W. (1968) · Science · doi:10.1126/science.159.3819.1119 · Cited by 194
Aphagia and Adipsia After Preferential Destruction of Nerve Cell Bodies in Hypothalamus
Grossman, S. P., Dacey, D. M., Halaris, A. E., Collier, T. J., & Routtenberg, A. (1978) · Science · doi:10.1126/science.705344 · Cited by 185
Louilot, A., Moal, M. L., & Simon, H. (1986) · Brain Research · doi:10.1016/0006-8993(86)90646-3 · Cited by 168
Detecting behaviorally relevant changes in extracellular dopamine with microdialysis
Church, W. H., Justice, J. B., & Neill, D. B. (1987) · Brain Research · doi:10.1016/0006-8993(87)91150-4 · Cited by 148
Hernandez, L., Lee, F., & Hoebel, B. G. (1987) · Brain Research Bulletin · doi:10.1016/0361-9230(87)90047-5 · Cited by 120
Self-citationEFFECTS OF ELECTRICAL STIMULATION OF THE NIGROSTRIATAL PATHWAY OF THE RAT ON DOPAMINE METABOLISM
Korf, J., Grasdijk, L., & Westerink, B. H. C. (1976) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1976.tb01514.x · Cited by 114
Intra-nucleus accumbens amphetamine: Dose-dependent effects on food intake
Evans, K., & Vaccarino, F. J. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90102-4 · Cited by 73
McCaleb, M. L., & Myers, R. D. (1979) · Brain Research Bulletin · doi:10.1016/0361-9230(79)90108-4 · Cited by 51
Rolls, E. T. (1998) · doi:10.1093/oso/9780198524649.003.0005 · Cited by 46
Hernández, L., & Hoebel, B. G. (1989) · Behavioral Neuroscience · doi:10.1037//0735-7044.103.2.412 · Cited by 29
Self-citationContributions of dopamine terminal areas to amphetamine-induced anorexia and adipsia
Carr, G. D., & White, N. M. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90223-6 · Cited by 29
Hernández, L., & Hoebel, B. G. (1989) · Behavioral Neuroscience · doi:10.1037/0735-7044.103.2.412 · Cited by 27
Self-citationHypothalamic Reward and Aversion: a Link between Metabolism and Behavior
Hernández, L., & Hoebel, B. G. (2015) · KARGER eBooks · doi:10.1159/000401834 · Cited by 16
Self-citationder Heyden, J. A. M. V. (1984) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(84)80041-6 · Cited by 14
IXth international conference on the physiology of food and fluid intake
(1986) · Appetite · doi:10.1016/s0195-6663(86)80029-0 · Cited by 7
Research works printed but not linked: 3
- Brugger, 1943, Fresstrieb als hypothalamisches symptom, Helv. Physiol. Pharmacol. Acta, 1, 183
- Collier, 1983, Life in a closed economy: The ecology of learning and motivation, vol. 3
- Morgane, 1979, Historical and modern concepts of hypothalamic organization and function, vol. 1, 1
Cited by
Sorted by citations
Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450
Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward
Kelley, A. E., Baldo, B. A., Pratt, W. E., & Will, M. J. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.066 · Cited by 752
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
Zhou, Q.-Y., & Palmiter, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90145-0 · Cited by 731
Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632
Alcaro, A., Huber, R., & Panksepp, J. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.07.014 · Cited by 661
Metadata
- Authors
- Hernandez, L., & Hoebel, B. G.
- Affiliations
- Princeton University (US)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 44
- Issue
- 4-5
- Pages
- 599-606
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2066841804
- Cited by
- 355
- References
- 36
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 3 · 2022: 12 · 2021: 7 · 2020: 49 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 11 · 2014: 11 · 2013: 9 · 2012: 14
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA 03597)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- feeding behavior, dopamine turnover, nucleus accumbens, mesolimbic dopamine system, extracellular dopamine, dihydroxyphenylacetic acid, homovanillic acid, ventral striatum, food reward
- MeSH terms
- Animals, Body Weight, Corpus Striatum, Dopamine, Eating, Electric Stimulation, Female, Hunger, Hypothalamic Area, Lateral, Male, Neural Pathways, Nucleus Accumbens, Rats, Inbred Strains, Receptors, Dopamine, Septal Nuclei, Rats
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