Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise

McBride, Todd A.; Gorin, Fredric A.; Carlsen, Richard C.

doi:10.1016/0047-6374(95)01629-e

Cited by 89Muscle Physiology and DisordersExercise and Physiological ResponsesCardiovascular and exercise physiology

Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise

McBride, Todd A., Gorin, Fredric A., Carlsen, Richard C.·1995·Mechanisms of Ageing and Development

DOI 10.1016/0047-6374(95)01629-e

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Abstract

We tested the hypothesis that exposure to eccentric (lengthening) contractions results in greater damage and more prolonged recovery in aged rat muscle (32 months) than in adult muscle (6 months), and that the adaptation usually associated with a single exposure to eccentric exercise is reduced in the aged muscle. Experiments were performed using a new rat model for aging studies. Fisher 344/Brown Norway F1 Hybrid. An ankle flexor, the tibialis anterior (TA), was subjected to a series of 24 eccentric contractions in situ and contractile function was assessed 1, 2, 5 and 14 days following. Eccentric exercise produced a similar reduction in maximum specific twitch and tetanic tension in the aged and adult muscles at 1 and 2 days postexercise. Adult muscles recovered by 5 days, while aged TA remained significantly impaired. Aged TA was fully restored by 14 days. Exercise adaptation was tested by subjecting the TA to a second exercise 14 days following the first. Contractile function was determined 2 days following the second exercise. Adult TA maintained its pre-exercise specific force following the second exercise, while aged TA again showed a significant reduction. Thus, a single exposure to eccentric exercise produced complete adaptation in the adult TA, but not in the aged muscles.

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Declines in functional capacity with eccentric contractions were similar between adult and old mice and between treatments.
“Consistent with previous studies in rodents (45, 46), these declines in functional capacity with eccentric contractions were similar between the adult and old mice and between treatments.”
From Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice (2021) · cites this paper as [45]

Myofibrillar damage following intense eccentric exercise in man
Fridén, J., Sjöström, M., & Ekblom, B. (1983) · International Journal of Sports Medicine · doi:10.1055/s-2008-1026030 · Cited by 1,005 · see citing works
Muscle function after exercise-induced muscle damage and rapid adaptation
CLARKSON, P. M., NOSAKA, K., & BRAUN, B. (1992) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199205000-00004 · Cited by 970 · see citing works
Contractile properties of skeletal muscles from young, adult and aged mice.
Brooks, S. V., & Faulkner, J. A. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017279 · Cited by 777 · see citing works
Exercise-Induced Muscle Damage and Adaptation
Ebbeling, C. B., & Clarkson, P. M. (1989) · Sports Medicine · doi:10.2165/00007256-198907040-00001 · Cited by 598 · see citing works
Repeated high-force eccentric exercise: effects on muscle pain and damage
Newham, D. J., Jones, D. A., & CLARKSON, P. M. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.4.1381 · Cited by 494 · see citing works
Structural and mechanical basis of exercise-induced muscle injury
Fridén, J. O., & Lieber, R. L. (1992) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199205000-00005 · Cited by 478 · see citing works
Skeletal muscle weakness in old age: underlying mechanisms.
Brooks, S. V., & Faulkner, J. A. (1994) · PubMed · Cited by 463 · see citing works
Initial events in exercise-induced muscular injury
BEN KIBLER, C. W., & ARMSTRONG, R. B. (1990) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199008000-00002 · Cited by 457 · see citing works
Skeletal muscle weakness in old age
Brooks, S. V., & Faulkner, J. A. (1994) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199404000-00006 · Cited by 364 · see citing works
Free radical injury to skeletal muscles of young, adult, and old mice
Zerba, E., Komorowski, T. E., & Faulkner, J. A. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.3.c429 · Cited by 279 · see citing works
Exercise-induced satellite cell activation in growing and mature skeletal muscle
Darr, K. C., & Schultz, E. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.5.1816 · Cited by 268 · see citing works
Eccentric Action of Muscles
STAUBLR, W. T. (1989) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-198900170-00008 · Cited by 251 · see citing works
Contraction-induced injury: recovery of skeletal muscles in young and old mice
Brooks, S. V., & Faulkner, J. A. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.3.c436 · Cited by 238 · see citing works
Selective damage of fast glycolytic muscle fibres with eccentric contraction of the rabbit tibialis anterior
Lieber, R. L., & Fridén, J. O. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08446.x · Cited by 217 · see citing works
Plasma creatine kinase activity and exercise-induced muscle damage in older men
Manfredi, T. G., Fielding, R. A., REILLY, K. P. O., MEREDITH, C. N., LEE, H. Y., & Evans, W. J. (1991) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199109000-00006 · Cited by 182 · see citing works
Enhancement and diminution of mechanical tension evoked by staircase and by tetanus in rat muscle
Krarup, C. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013589 · Cited by 161 · see citing works
The consequences of eccentric contractions and their relationship to delayed onset muscle pain
Newham, D. J. (1988) · European Journal of Applied Physiology · doi:10.1007/bf00635995 · Cited by 149 · see citing works
Effects of age on enzyme-histochemical fibre spectra and contractile properties of fast- and slow-twitch skeletal muscles in the rat
Larsson, L., & Edström, L. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90143-7 · Cited by 144 · see citing works
Effects of repeated eccentric contractions on structure and mechanical properties of toad sartorius muscle
Wood, S. A., Morgan, D. L., & Proske, U. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.3.c792 · Cited by 141 · see citing works
Skeletal muscle enlargement with weight-lifting exercise by rats
Wong, T., & Booth, F. W. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.65.2.950 · Cited by 123 · see citing works
Muscle Soreness After Exercise: Implications of Morphological Changes
Fridén, J. O. (1984) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025881 · Cited by 92 · see citing works
Plasticity of Muscle Fiber and Motor Unit Types
Gordon, T., & PATTULLO, M. C. (1993) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-199301000-00011 · Cited by 86 · see citing works
Reinnervation of long-term denervated rat muscle freely grafted into an innervated limb
Carlson, B. M., & Faulkner, J. A. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90077-5 · Cited by 83 · see citing works
Enhanced protein breakdown after eccentric exercise in young and older men
Fielding, R. A., Meredith, C. N., O’Reilly, K., Frontera, W. R., Cannon, J. G., & Evans, W. J. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.2.674 · Cited by 79 · see citing works
Exercise-induced Muscle Damage, Repair, and Adaptation in Old and Young Subjects
CLARKSON, P. M., & Dedrick, M. E. (1988) · Journal of Gerontology · doi:10.1093/geronj/43.4.m91 · Cited by 74 · see citing works
The effects of eccentric exercise on motor performance in young and older women
Dedrick, M. E., & Clarkson, P. M. (1990) · European Journal of Applied Physiology · doi:10.1007/bf00839156 · Cited by 70 · see citing works
The protective effect of damaging eccentric exercise against repeated bouts of exercise in the mouse tibialis anterior muscle
Sacco, P., & Jones, D. (1992) · Experimental Physiology · doi:10.1113/expphysiol.1992.sp003642 · Cited by 59 · see citing works
Decline of isometric force and fatigue resistance in skeletal muscles from spontaneously hypertensive rats
Carlsen, R. C., & Gray, S. D. (1987) · Experimental Neurology · doi:10.1016/0014-4886(87)90136-1 · Cited by 27 · see citing works
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Decrease in force potentiation and appearance of α-adrenergic mediated contracture in aging rat skeletal muscle
Carlsen, R. C., & Walsh, D. A. (1987) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf02181463 · Cited by 23 · see citing works
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Spiers, S., McArdle, F., & Jackson, M. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06669.x · Cited by 10 · see citing works
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Lee, K., Kletzien, H., Connor, N. P., Schultz, E., Chamberlain, C. S., & Bless, D. M. (2012) · The Laryngoscope · doi:10.1002/lary.23589 · Cited by 9 · see citing works
Aging with Muscular Dystrophy: Pathophysiology and Clinical Management
Carter, G. T., Weiss, M. D., Chamberlain, J. R., Han, J. J., Abresch, R. T., Miró, J., & Jensen, M. P. (2010) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2009.12.001 · Cited by 9 · see citing works
Functional recovery from eccentric injury is maintained in sarcopenic mouse muscle
Valencia, A. P., Samuelson, A. T., Stuppard, R. S., & Marcinek, D. J. (2021) · JCSM Rapid Communications · doi:10.1002/rco2.33 · Cited by 5 · see citing works
Effects of age and glutathione levels on oxidative stress in rats after chronic exposure to stretch-shortening contractions
Hollander, M. S., Baker, B. A., Ensey, J. S., Kashon, M. L., & Cutlip, R. G. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1246-8 · Cited by 7 · see citing works
Differential effects of post-natal development, animal strain and long term recovery on the restoration of neuromuscular function after neuromyotoxic injury in rat
Vignaud, A., Caruelle, J. P., Martelly, I., & Ferry, A. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2005.09.012 · Cited by 7 · see citing works
Oxidative stress and the pathogenesis of sarcopenia
Lopez, M. E., Zainal, T. A., Chung, S. S., Aiken, J. M., & Weindruch, R. H. (2000) · Elsevier eBooks · doi:10.1016/b978-044482650-3/50029-8 · Cited by 7 · see citing works
Stretch-shortening cycles protect against the age-related loss of power generation in rat single muscle fibres
Patterson, M. A., Hinks, A., Njai, B. S., Dalton, B. E., Hubbard, E. F., & Power, G. A. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112423 · Cited by 6 · see citing works
Consequences of Skeletal Muscle Injury Induced by Unaccustomed Exercise
Schneider, B. S. P., & Sannes, H. J. (2001) · Orthopaedic Nursing · doi:10.1097/00006416-200109000-00009 · Cited by 6 · see citing works
Skeletal Muscle Aging
Broome, C. S., Vasilaki, A., & McArdle, A. (2003) · Springer eBooks · doi:10.1007/978-94-017-0673-5_3 · Cited by 5 · see citing works
Residual force enhancement is not altered while force depression is amplified at the cellular level in old age
Njai, B. S., Hinks, A., Patterson, M. A., & Power, G. A. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.248155 · Cited by 4 · see citing works
Submaximal Eccentric Training During Immobilization Does Not Prevent Serial Sarcomere Loss or Impairments in Mechanical Function in Old or Young Rats
Hinks, A., Vlemmix, E., & Power, G. A. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaf082 · Cited by 6 · see citing works
Increasing indices of frailty in aged female mice are associated with impaired skeletal muscle resilience to downhill running stress
Laskin, G. R., Perazza, L. R., Graber, T. G., Mazonson, B. R., Kim, Y.-T., Verdi, L. J., & Thompson, L. V. (2025) · GeroScience · doi:10.1007/s11357-025-01856-7 · Cited by 3 · see citing works
Fish Oil Supplement Mitigates Muscle Injury In Vivo and In Vitro: A Preliminary Report
Russ, D. W., Sehested, C., Banford, K. K., & Weisleder, N. L. (2024) · Nutrients · doi:10.3390/nu16203511 · Cited by 3 · see citing works
Adaptations mécaniques et neurophysiologiques induites par la sollicitation musculaire excentrique : l'effet protecteur
Michaut, A., & Pousson, M. (2004) · Science & Sports · doi:10.1016/j.scispo.2004.06.001 · Cited by 3 · see citing works
Comparative Skeletal Muscle Aging
Marcinek, D. J., Wanagat, J., & Villarin, J. J. (2009) · Springer eBooks · doi:10.1007/978-90-481-3465-6_13 · Cited by 3 · see citing works
Aging Effects on Muscle Properties and Human Performance
Jubrias, S. A., & Conley, K. E. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50048-2 · Cited by 3 · see citing works
Muscle Repair after Injury and Disease
Ambrosio, F., Li, Y., Ūsas, A., Boninger, M. L., & Huard, J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-239-7_22 · Cited by 3 · see citing works
Serial sarcomerogenesis does not contribute to the initial repeated bout effect in skeletal muscle
Vlemmix, E., Hinks, A., & Power, G. A. (2025) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2025.112767 · Cited by 2 · see citing works
Skeletal muscle aging
Close, G. L., Haggan, P., & McArdle, A. (2007) · Reviews in Clinical Gerontology · doi:10.1017/s0959259808002360 · Cited by 2 · see citing works
Efecto del ejercicio físico agotador sobre el estrés oxidativo asociado al envejecimiento
Malavés, R. A. (2003) · TDX (Tesis Doctorals en Xarxa) · Cited by 2 · see citing works
Addition and Loss of Serial Sarcomeres—Implications for Muscle Mechanical Function
Hinks, A., & Power, G. A. (2025) · Springer eBooks · doi:10.1007/978-3-031-44270-4_10 · Cited by 1 · see citing works
Muscular Pain Mechanisms: Brief Review with Special Consideration of Delayed-Onset Muscle Soreness
Mizumura, K. (2008) · Springer eBooks · doi:10.1007/978-4-431-73242-6_12 · Cited by 1 · see citing works
Response to stimulation-evoked eccentric muscle contractions in hypertensive rats
Willett, J. A., Gray, S. D., & Carlsen, R. C. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200008000-00006
Self-citation
Stiffening of the extracellular matrix in skeletal muscle of aged rats and the effect on muscle fiber mechanotransduction
Eklund, K. (2011) · ThinkTech (Texas Tech University)
Characterization of skeletal muscle performance and morphology following acute and chronic mechanical loading paradigms
Baker, B. A. (2007) · doi:10.33915/etd.4289
Exercise-Induced Fatigue and Recovery in the Ageing Athlete
Fell, J. W. (2006) · Griffith Research Online · doi:10.25904/1912/1059
Chapitre 21. Fatigue et récupération chez l’athlète « master »
Louis, J. B., & Brisswalter, J. (2013) · INSEP-Éditions eBooks · doi:10.4000/books.insep.1389
Muskeltrauma in der primären Hüftendoprothetik unter Berücksichtigung von Alter und BMI sowie in Abhängigkeit vom operativen Zugangsweg: Minimalinvasiver anterolateraler vs. modifizierter transglutealer Zugang
Müller, M. E., Tohtz, S. W., Dewey, M., Springer, I., & Perka, C. (2011) · Der Orthopäde
Beyond the first bout: Adaptations to repeated injuries across physiological and pathological conditions
Baumann, C. W., Ingalls, C. P., Nosaka, K., & Call, J. A. (2026) · Physiological Reports · doi:10.14814/phy2.70929

Aging Blunts The Repeated Bout Effect In Skeletal Muscle
Baumann, C. W., & Lowe, D. A. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000670156.93752.a3 · Cited by 1 · see citing works
Age-dependent Muscle Adaptation after Chronic Stretch-shortening Contractions in Rats
Rader, E. P., Layner, K. N., Triscuit, A. M., Chetlin, R. D., Ensey, J. S., & Baker, B. A. (2016) · Aging and Disease · doi:10.14336/ad.2015.0920 · Cited by 26 · see citing works
The Repeated Bout Effect: Functional And Molecular Changes With Advancing Age
Baumann, C. W., Brown, A. M., & Ganjayi, M. S. (2023) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000982708.30953.08
Increased depolarization, prolonged recovery and reduced adaptation of the resting membrane potential in aged rat skeletal muscles following eccentric contractions
McBride, T. A. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00111-1 · Cited by 16 · see citing works
Self-citation
Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males
Quinlan, J. I., Franchi, M. V., Gharahdaghi, N., Badiali, F., Francis, S., Hale, A., Phillips, B. E., Szewczyk, N. J., Greenhaff, P. L., Smith, K., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00396-0 · Cited by 69 · see citing works

Authors: McBride, T. A., Gorin, F. A., & Carlsen, R. C.
Affiliations: University of California, Davis (US)
Corresponding author: McBride, Todd A.
Venue: Mechanisms of Ageing and Development
Publisher: Elsevier BV
Published: 1995-09
Volume: 83
Issue: 3
Pages: 185-200
ISSN: 0047-6374 (ISSN-L)
DOI: 10.1016/0047-6374(95)01629-e
OpenAlex: W1972939655
Cited by: 89
References: 29
Citations by year: 2026: 1 · 2025: 4 · 2024: 6 · 2022: 2 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2014: 1 · 2013: 3 · 2012: 3
FWCI: 0.25
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mechanisms of Ageing and Development (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG00429)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: aging, eccentric exercise, skeletal muscle, tibialis anterior, post-exercise recovery, exercise adaptation, muscle damage, contractile function, specific force
MeSH terms: Adaptation, Physiological, Aging, Animals, Female, Muscle Contraction, Physical Conditioning, Animal, Rats, Inbred BN, Rats, Inbred F344, Muscle, Skeletal, Rats

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Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise

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