Age-related functional changes and susceptibility to eccentric contraction-induced damage in skeletal muscle cell
Open accessAbstract
Depending upon external loading conditions, skeletal muscles can either shorten, lengthen, or remain at a fixed length as they produce force. Fixed-end or isometric contractions stabilize joints and allow muscles to act as active struts during locomotion. Active muscles dissipate energy when they are lengthened by an external force that exceeds their current force producing capacity. These unaccustomed eccentric activities often lead to muscle weakness, soreness, and inflammation. During aging, the ability to produce force under these conditions is reduced and appears to be due to not only reductions in muscle mass but also to alterations in the basic mechanisms of contraction. These alterations include impairments in the excitation-contraction process, and the action of the cross-bridges. Also, it is well known that age-related skeletal muscle atrophy is characterized by a preferential atrophy of fast fibers, and increased susceptibility to fast muscle fiber when aged muscles are exposed to eccentric contraction followed by the impaired recovery process has been reported. Taken together, the selective loss of fast muscle fiber in aged muscle could be affected by eccentric-induced muscle damage, which has significant implication to identify the etiology of the age-related functional changes. Therefore, in this review the alteration of age-related muscle function and its impact to/of eccentric induced muscle damage and recovery will be addressed in detail.
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Obese adults have larger fiber cross-sectional area.
“Choi (2016) found that obese adults had larger fiber cross-sectional area.”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Choi (2016)
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- Authors
- Choi, S.-J.
- Affiliations
- Kyungsung University (KR)
- Corresponding author
- Choi, Seung-Jun
- ORCID
- Choi, Seung-Jun
- Venue
- Integrative Medicine Research
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 5
- Issue
- 3
- Pages
- 171-175
- ISSN
- 2213-4220 (ISSN-L)
- PMC
- PMC5390413
- OpenAlex
- W2398480590
- Cited by
- 21
- References
- 63
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 1 · 2018: 2
- FWCI
- 0.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Integrative Medicine Research (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Kyungsung University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- skeletal muscle aging, eccentric contraction, fast-twitch muscle, excitation-contraction coupling, muscle force production, muscle damage recovery, age-related muscle weakness
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