Circulating concentrations of oxytocin during the estrous cycle and early pregnancy in sheep
Abstract
Plasma concentrations of oxytocin and progesterone have been measured by radioimmunoassay in jugular venous blood obtained daily from 5 sheep during 2 estrous cycles and in early pregnancy. Concentrations of oxytocin were relatively high (15-30) pg/ml) during the luteal phase of the cycle, but fell at estrus (to 1-17 pg/ml). A fall in oxytocin was also observed on day 15 of pregnancy, when, as expected, progesterone levels remained high. It is suggested that raised basal levels of oxytocin are unlikely to cause the increased uterine release of prostaglandin F2 alpha which occurs at the end of the estrous cycle.
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By the 1980s, many laboratories had generated radioimmunoassays for oxytocin using independently produced antibodies, and most but not all required extraction.
“By the 1980s, many laboratories had generated radioimmunoassays for oxytocin, using independently produced antibodies 58, 72, 73, 74, 94, 95, 96, 97, 98] and most, but not all 99, 100, required extraction.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [97]
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Plasma oxytocin increases in the human sexual response
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- Authors
- Sheldrick, E. L., & Flint, A. P. F.
- Venue
- Prostaglandins
- Publisher
- Elsevier BV
- Published
- 1981-10
- Volume
- 22
- Issue
- 4
- Pages
- 631-636
- ISSN
- 0090-6980 (ISSN-L)
- OpenAlex
- W2044949300
- Cited by
- 116
- References
- 9
- Citations by year
- 2023: 1 · 2019: 1 · 2016: 1
- FWCI
- 22.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Prostaglandins (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- oxytocin, estrous cycle, early pregnancy, sheep, progesterone, luteal phase, estrus, prostaglandin F2alpha, plasma hormone levels
- MeSH terms
- Animals, Estrus, Female, Male, Oxytocin, Pregnancy, Pregnancy, Animal, Progesterone, Sheep
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