Cerebrospinal fluid and plasma concentrations of oxytocin and vasopressin during parturition and vaginocervical stimulation in the sheep
Abstract
Simultaneous blood and cerebrospinal fluid (CSF) samples were taken from conscious sheep before, during and after parturition. Concentrations of plasma and CSF oxytocin were significantly elevated during contractions and particularly at birth. Mean prepartum CSF concentrations of oxytocin were around 55% of those found in plasma but postpartum they were up to 2-fold higher than those in plasma. Plasma concentrations of oxytocin were only significantly elevated, compared to prepartum levels, for 15 min postpartum whereas those in CSF were increased for the whole of the 120 min postpartum sampling period. Plasma, but not CSF, concentrations of arginine-vasopressin (AVP) were significantly raised during contractions and birth, and for 15 min postpartum. During the prepartum period CSF AVP concentrations were 67% of those found in plasma whereas at birth plasma levels were 10-fold higher than in CSF. In a separate experiment it was shown that 5 min of mechanical vaginocervical stimulation also stimulated significant increases in CSF and plasma oxytocin concentrations and in plasma vasopressin. Results support previous work suggesting an important role for central oxytocin release in the postpartum induction of maternal behavior and demonstrate that elevated concentrations of oxytocin in the CSF are present for a greater period than in blood. Elevated plasma AVP concentrations during contractions, birth or vaginocervical stimulation may be stimulated by stress associated with these stimuli.
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Central oxytocin seems fundamental for mother-infant bonding, as cerebral injections of oxytocin induce acceptance of an unfamiliar lamb by ewes even after initial bonding.
“Central oxytocin seems fundamental for this mother-infant bonding, as cerebral injections of oxytocin induce acceptance of an unfamiliar lamb by ewes even after initial bonding”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Kendrick et al. 1991
Oxytocin is released into blood and brain during parturition, but in sheep plasma levels were elevated for only 15 minutes postpartum while CSF levels remained increased for more than 120 minutes.
“Oxytocin is released into blood and brain during parturition, but in sheep (81), plasma concentrations were only elevated for 15min postpartum whereas those in CSF were increased for >120min.”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [81]
Cites
Pedersen, C. A., & Prange, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6661 · Cited by 841 · see citing works
Oxytocin induces maternal behavior in virgin female rats
Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J. (1982) · Science · doi:10.1126/science.7071605 · Cited by 770 · see citing works
Intracerebroventricular oxytocin stimulates maternal behaviour in the sheep
Kendrick, K. M., Keverne, E. B., & Baldwin, B. A. (2008) · Neuroendocrinology · doi:10.1159/000124796 · Cited by 373 · see citing works
Self-citationMens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)90478-x · Cited by 360 · see citing works
Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats
Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000124125 · Cited by 322 · see citing works
Vasopressin : principles and properties
Gash, D. M., & Boer, G. J. (1987) · Plenum Press eBooks · Cited by 250 · see citing works
Vaginal stimulation: an important determinant of maternal bonding in sheep
Keverne, E. B., Levy, F., Poindron, P., & Lindsay, D. R. (1983) · Science · doi:10.1126/science.6849123 · Cited by 230 · see citing works
Kendrick, K. M., Keverne, E. B., Baldwin, B. A., & Sharman, D. F. (2008) · Neuroendocrinology · doi:10.1159/000124638 · Cited by 187 · see citing works
Self-citationKendrick, K. M., Keverne, E. B., Chapman, C., & Baldwin, B. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)91455-2 · Cited by 175 · see citing works
Self-citationKendrick, K. M., Keverne, E. B., Chapman, C., & Baldwin, B. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)91447-3 · Cited by 168 · see citing works
Self-citationJones, P. M., & Robinson, I. C. A. F. (2008) · Neuroendocrinology · doi:10.1159/000123316 · Cited by 148 · see citing works
Oxytocin antiserum delays onset of ovarian steroid-induced maternal behavior
Pedersen, C. A., Caldwell, J. D., Johnson, M. F., Fort, S. A., & Prange, A. J. (1985) · Neuropeptides · doi:10.1016/0143-4179(85)90108-8 · Cited by 137 · see citing works
Circulating concentrations of oxytocin during the estrous cycle and early pregnancy in sheep
Sheldrick, E. L., & Flint, A. P. F. (1981) · Prostaglandins · doi:10.1016/0090-6980(81)90072-1 · Cited by 116 · see citing works
Peridural anesthesia disturbs maternal behavior in primiparous and multiparous parturient ewes
Krehbiel, D., Poindron, P., Lévy, F., & Prud'homme, M.-J. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90031-x · Cited by 96 · see citing works
Raggenbass, M., Dubois‐Dauphin, M., Charpak, S., & Dreifuss, J. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3926 · Cited by 79 · see citing works
Keverne, E. B., & Kendrick, K. M. (1991) · Brain Research · doi:10.1016/0006-8993(91)90492-e · Cited by 75 · see citing works
Self-citationA Highly Specific Antiserum for Arginine Vasopressin1
Moore, G. R., Lutterodt, A., Burford, G. D., & Lederis, K. P. (1977) · Endocrinology · doi:10.1210/endo-101-5-1421 · Cited by 70 · see citing works
Strott, C. A., SUNDEL, H., & Stahlman, M. T. (1974) · Endocrinology · doi:10.1210/endo-95-5-1327 · Cited by 57 · see citing works
Maternal and Fetal Arginine Vasopressin in the Chronically Catheterised Sheep
Alexander, P., BASHORE, R. A., Britton, H. G., & Forsling, M. L. (2009) · Biology of the Neonate · doi:10.1159/000240696 · Cited by 57 · see citing works
Plasma Levels of Oxytocin and Vasopressin before, during and after Parturition in Cows
Landgraf, R., Schulz, J. A., Eulenberger, K., & Wilhelm, J. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1210243 · Cited by 47 · see citing works
PERIPHERAL PLASMA LEVELS OF OXYTOCIN AND VASOPRESSIN IN THE MARE DURING PARTURITION
Allen, W. E., Chard, T., & Forsling, M. L. (1973) · Journal of Endocrinology · doi:10.1677/joe.0.0570175 · Cited by 44 · see citing works
Vasopressin Receptors in the Brain and Pituitary
van Leeuwen, F. W. (1987) · Springer eBooks · doi:10.1007/978-1-4615-8129-1_12 · Cited by 44 · see citing works
Role of central oxytocin in the control of the milk ejection reflex
Freund‐Mercier, M. J., Moos, F., Poulain, D. A., Richard, P., Rodriguez, F., Theodosis, D. T., & Vincent, J. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90085-8 · Cited by 41 · see citing works
Hartman, R. D., Rosella-Dampman, L. M., Emmert, S. E., & Summy‐Long, J. Y. (1986) · Brain Research · doi:10.1016/0006-8993(86)91344-2 · Cited by 39 · see citing works
Independent release of oxytocin and vasopressin during parturition in the rabbit
Haldar, J. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009040 · Cited by 38 · see citing works
Vasopressin, but not oxytocin, is released in response to water deprivation in conscious goats
Thornton, S. N., Leng, G., Bicknell, R. J., Chapman, C., & Purdew, T. (1986) · Journal of Endocrinology · doi:10.1677/joe.0.1100335 · Cited by 36 · see citing works
Arginine Vasopressin during Gestation and Parturition in Sheep Fetus
Stark, R. I., Daniel, S. S., Husain, K. M., James, S., & Wiele, R. L. V. (2009) · Biology of the Neonate · doi:10.1159/000241179 · Cited by 33 · see citing works
Effects of pregnancy and labor on oxytocin levels in human plasma and cerebrospinal fluid.
Takeda, S., Kuwabara, Y., & Mizuno, M. (1985) · Endocrinologia Japonica · doi:10.1507/endocrj1954.32.875 · Cited by 32 · see citing works
SIMULTANEOUS RELEASE OF OXYTOCIN AND NEUROPHYSIN DURING PARTURITION IN THE GOAT
McNeilly, A. S., Martin, M. J., Chard, T., & Hart, I. C. (1972) · Journal of Endocrinology · doi:10.1677/joe.0.0520213 · Cited by 30 · see citing works
Effect of naloxone on oxytocin and vasopressin release during vaginocervical stimulation in the goat
Seckl, J. R., & Lightman, S. L. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.1150317 · Cited by 21 · see citing works
Vasopressin release in sheep following various degrees of rehydration
Blair-West, J. R., Gibson, A. P., Sheather, S. J., Woods, R. L., & Brook, A. H. (1987) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1987.253.4.r640 · Cited by 14 · see citing works
Seckl, J. R., & Lightman, S. L. (1988) · Journal of Endocrinology · doi:10.1677/joe.0.1160273 · Cited by 9 · see citing works
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The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., Dziobek, I., Gallinat, J., Wagner, M., Maier, W., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5538-09.2010 · Cited by 771 · see citing works
Self-citationIntranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 615 · see citing works
Oxytocin, Neural Plasticity, and Social Behavior
Froemke, R. C., & Young, L. J. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102320-102847 · Cited by 487 · see citing works
“Central oxytocin seems fundamental for this mother-infant bonding, as cerebral injections of oxytocin induce acceptance of an unfamiliar lamb by ewes even after initial bonding (Kendrick et al. 1991, 1992).”
BackgroundStriepens, N., Kendrick, K. M., Hanking, V., Landgraf, R., Wüllner, U., Maier, W., & Hurlemann, R. (2013) · Scientific Reports · doi:10.1038/srep03440 · Cited by 452 · see citing works
Self-citationCharacterization of the oxytocin system regulating affiliative behavior in female prairie voles
Ross, H. E., Cole, C. D., Smith, Y., Neumann, I. D., Landgraf, R., Murphy, A. Z., & Young, L. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.055 · Cited by 309 · see citing works
The magnocellular oxytocin system, the fount of maternity: Adaptations in pregnancy
Russell, J. A., Leng, G., & Douglas, A. J. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00104-8 · Cited by 295 · see citing works
Dopamine in the medial amygdala network mediates human bonding
Atzil, S., Touroutoglou, A., Rudy, T., Salcedo, S., Feldman, R., Hooker, J. M., Dickerson, B. C., Catana, C., & Barrett, L. F. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612233114 · Cited by 182 · see citing works
Lévy, F., Kendrick, K. M., Goode, J. A., Guevara‐Guzmán, R., & Keverne, E. B. (1995) · Brain Research · doi:10.1016/0006-8993(94)01236-b · Cited by 181 · see citing works
Self-citationOxytocin Control of Maternal Behavior Regulation by Sex Steroids and Offspring Stimuli<sup>a</sup>
PEDERSEN, C. A. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51916.x · Cited by 172 · see citing works
Intranasal administration of oxytocin: behavioral and clinical effects, a review
Veening, J. G., & Olivier, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.012 · Cited by 169 · see citing works
Pain and discomfort caused by parturition in cows and sows
Mainau, E., & Manteca, X. (2011) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2011.10.020 · Cited by 159 · see citing works
The role of oxytocin in male and female reproductive behavior
Veening, J. G., A, T. R. D. J., Waldinger, M. D., Korte, S. M., & Olivier, B. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.045 · Cited by 156 · see citing works
Sex, parturition and motherhood without oxytocin?
Russell, J., & Leng, G. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1570343 · Cited by 150 · see citing works
Kendrick, K. M., Keverne, E. B., Hinton, M. R., & Goode, J. A. (1992) · Brain Research · doi:10.1016/0006-8993(92)90631-i · Cited by 150 · see citing works
Self-citationBlaustein, J. D., & Erskine, M. S. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50004-4 · Cited by 147 · see citing works
Dwyer, C. M., & Lawrence, A. B. (1998) · Applied Animal Behaviour Science · doi:10.1016/s0168-1591(97)00148-2 · Cited by 133 · see citing works
Elevation of oxytocin levels early post partum in women
Nissen, E., Lilja, G., Widström, A., & Uvnäs‐Moberg, K. (1995) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016349509024384 · Cited by 131 · see citing works
Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1
Nersesyan, Y., Demirkhanyan, L. H., Cabezas-Bratesco, D., Oakes, V., Kusuda, R., Dawson, T., Sun, X., Cao, C., Cohen, A., Chelluboina, B., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.063 · Cited by 131 · see citing works
Oxytocin-messages via the cerebrospinal fluid: Behavioral effects; a review
Veening, J. G., A, T. R. D. J., & Barendregt, H. P. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.05.004 · Cited by 126 · see citing works
Overview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121 · see citing works
Self-citationDwyer, C. M. (2008) · Journal of Animal Science · doi:10.2527/jas.2007-0404 · Cited by 117 · see citing works
The physiology and pharmacology of oxytocin in labor and in the peripartum period
Uvnäs-Moberg, K. (2024) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2023.04.011 · Cited by 118 · see citing works
Smith, A. S., Korgan, A. C., & Young, W. S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104324 · Cited by 107 · see citing works
Oxytocin and same-sex social behavior in female meadow voles
Beery, A. K., & Zucker, I. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.023 · Cited by 108 · see citing works
Quintana, D. S., Guastella, A. J., Westlye, L. T., & Andreassen, O. A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.166 · Cited by 107 · see citing works
Hydbring, E., Madej, A., MacDonald, E., Drugge-Boholm, G., Berglund, B., & Olsson, K. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600075 · Cited by 107 · see citing works
Vocalisations between mother and young in sheep: effects of breed and maternal experience
Dwyer, C. M., McLean, K. A., Deans, L. A., Chirnside, J., Calvert, S., & Lawrence, A. B. (1998) · Applied Animal Behaviour Science · doi:10.1016/s0168-1591(97)00113-5 · Cited by 104 · see citing works
Broad, K. D., Lévy, F., Evans, G., Kimura, T., Keverne, E. B., & Kendrick, K. M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00782.x · Cited by 100 · see citing works
Self-citationTechnique for collecting cerebrospinal fluid in the cisterna magna of non-anesthetized rats
Consiglio, A. R., & Lucion, A. B. (2000) · Brain Research Protocols · doi:10.1016/s1385-299x(99)00062-8 · Cited by 99 · see citing works
Endocrinology of pregnancy in the dog: A review
Verstegen-Onclin, K., & Verstegen, J. (2008) · Theriogenology · doi:10.1016/j.theriogenology.2008.04.038 · Cited by 96 · see citing works
Physiological, Sensory, and Experiential Factors of Parental Care in Sheep
Léavy, F., Porter, R. H., Kendrick, K. M., Keverne, E. B., & Romeyer, A. (1996) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)60339-3 · Cited by 95 · see citing works
Self-citationBroad, K. D., Kendrick, K. M., SIRINATHSINGHJI, D. J. S., & Keverne, E. B. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00505.x · Cited by 90 · see citing works
Self-citationDwyer, C. M. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01657.x · Cited by 86 · see citing works
Yu, G.-Z., Kaba, H., Okutani, F., Takahashi, S., Higuchi, T., & Seto, K. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00599-4 · Cited by 83 · see citing works
Socialization, Hormones, and the Regulation of Maternal Behavior in Nonhuman Simian Primates
Pryce, C. R. (1996) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)60340-x · Cited by 80 · see citing works
Fernández, I. O., Gabriel, M. Á. M., Gil-Sánchez, A., García‐Segura, L. M., & Arévalo, M. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.007 · Cited by 78 · see citing works
Neuroendocrine control of maternal behavior in non-human and human mammals
Lévy, F. (2016) · Annales d Endocrinologie · doi:10.1016/j.ando.2016.04.002 · Cited by 77 · see citing works
Nowak, R., Keller, M., Val‐Laillet, D., & Lévy, F. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.03.021 · Cited by 75 · see citing works
Broad, K. D., Kendrick, K. M., SIRINATHSINGHJI, D. J. S., & Keverne, E. B. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00544.x · Cited by 73 · see citing works
Self-citationKendrick, K. M., Fabre‐Nys, C., Blache, D., Goode, J. A., & Broad, K. D. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00359.x · Cited by 67 · see citing works
Self-citationNuman, M. J., FLEMING, A., & Lévy, F. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50040-3 · Cited by 63 · see citing works
Rault, J. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.03.015 · Cited by 63 · see citing works
Spoljaric, A., Seja, P., Spoljaric, I., Virtanen, M. A., Lindfors, J., Uvarov, P., Summanen, M., Crow, A., Hsueh, B., Puskarjov, M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717337114 · Cited by 60 · see citing works
DOES THE BEHAVIOUR OF THE NEONATE INFLUENCE THE EXPRESSION OF MATERNAL BEHAVIOUR IN SHEEP?
Dwyer, C. M., & Lawrence, A. B. (1999) · Behaviour · doi:10.1163/156853999501379 · Cited by 58 · see citing works
Hudson, R. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90054-3 · Cited by 58 · see citing works
Hermes, R. E., Saragusty, J., Schaftenaar, W., Göritz, F., Schmitt, D. L., & Hildebrandt, T. (2008) · Theriogenology · doi:10.1016/j.theriogenology.2008.04.003 · Cited by 56 · see citing works
Luckman, S. M. (1995) · Brain Research · doi:10.1016/0006-8993(94)01271-i · Cited by 55 · see citing works
Uvnäs‐Moberg, K., Groß, M. M., Calleja‐Agius, J., & Turner, J. D. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1272270 · Cited by 53 · see citing works
Control of Synthesis and Release of Oxytocin in the Sheep Braina
Kendrick, K. M., & Keverne, E. B. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34349.x · Cited by 48 · see citing works
Self-citationVaginocervical stimulation releases oxytocin within the spinal cord in rats
Sansone, G. R., Gerdes, C. A., Steinman, J. L., Winslow, J. T., Ottenweller, J. E., Komisaruk, B. R., & Insel, T. R. (2002) · Neuroendocrinology · doi:10.1159/000057340 · Cited by 47 · see citing works
Oxytocin and Maternal Brain Plasticity
Kim, S., & Strathearn, L. (2016) · New Directions for Child and Adolescent Development · doi:10.1002/cad.20170 · Cited by 45 · see citing works
Lawrence, A. B., Petherick, J. C., McLean, K. A., Deans, L. A., Chirnside, J., Vaughan, A., Gilbert, C. L., Forsling, M. L., & Russell, J. A. (1995) · Animal Reproduction Science · doi:10.1016/0378-4320(94)01361-o · Cited by 46 · see citing works
Dwyer, C. M., Gilbert, C. L., & Lawrence, A. B. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.05.011 · Cited by 46 · see citing works
The lactation cycle in the sow: physiological and management contradictions
Hartmann, P. E., Smith, N., Thompson, M. J., Wakeford, C. M., & Arthur, P. G. (1997) · Livestock Production Science · doi:10.1016/s0301-6226(97)00076-6 · Cited by 45 · see citing works
McKee, D. T., Poletini, M. O., Bertram, R., & Freeman, M. E. (2007) · Endocrinology · doi:10.1210/en.2007-0646 · Cited by 44 · see citing works
Ma, X., Luo, L., Geng, Y., Zhao, W., Zhang, Q., & Kendrick, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00266 · Cited by 43 · see citing works
Self-citationProlactin secretory rhythm of mated rats induced by a single injection of oxytocin
Egli, M., Bertram, R., Toporikova, N., Sellix, M. T., Blanco, W., & Freeman, M. E. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00427.2005 · Cited by 42 · see citing works
Bienboire‐Frosini, C., Chabaud, C., Cozzi, A., Codecasa, E., & Pageat, P. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00524 · Cited by 42 · see citing works
Wathes, D. C., Smith, H. F., Leung, S. T., Stevenson, K. R., Meier, S., & Jenkin, G. (1996) · Reproduction · doi:10.1530/jrf.0.1060023 · Cited by 42 · see citing works
Olsson, K., Bergström, A., Kindahl, H., & Lagerstedt, A. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.0001-6772.2003.01178.x · Cited by 41 · see citing works
Williams, G. L., Gazal, O. S., Leshin, L. S., Stanko, R. L., & Anderson, L. L. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.1.295 · Cited by 39 · see citing works
Puder, B. A., & Papka, R. E. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1053 · Cited by 39 · see citing works
Neural circuit control of innate behaviors
Wei, X., Jiao, Z., Senol, E., Yao, J., Zhao, M., Zhao, Z., Chen, X., Cao, P., Fu, Y., Gao, Z., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-2043-2 · Cited by 38 · see citing works
Physiological effects induced by stimulation of cutaneous sensory nerves, with a focus on oxytocin
Moberg, K. U., & Petersson, M. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.10.001 · Cited by 37 · see citing works
Broad, K. D., Keverne, E. B., & Kendrick, K. M. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00260-l · Cited by 36 · see citing works
Self-citationAn evolutionary perspective on the behavioral consequences of exogenous oxytocin application
Ebitz, R. B., & Platt, M. L. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00225 · Cited by 35 · see citing works
A mathematical model for the mating-induced prolactin rhythm of female rats
Bertram, R., Egli, M., Toporikova, N., & Freeman, M. E. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00428.2005 · Cited by 32 · see citing works
Vandenheede, M., Nicks, B., Désiron, A., & Canart, B. (2001) · Applied Animal Behaviour Science · doi:10.1016/s0168-1591(01)00118-6 · Cited by 32 · see citing works
Ovum Pick‐up in Dairy Heifers: Does it Affect Animal Well‐being?
Petyim, S., Båge, R., Madej, A., & Larsson, B. (2007) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2006.00833.x · Cited by 32 · see citing works
Chapter 8 Neurobiology of Maternal Behavior in Sheep
Lévy, F., & Keller, M. (2008) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)00008-9 · Cited by 31 · see citing works
Patin, A., & Hurlemann, R. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-16522-6_10 · Cited by 32 · see citing works
Kendrick, K. M., da Costa, A. P., Hinton, M. R., & Keverne, E. B. (1992) · Applied Animal Behaviour Science · doi:10.1016/s0168-1591(05)80094-2 · Cited by 31 · see citing works
Self-citationA Tale of Two Rhythms: The Emerging Roles of Oxytocin in Rhythmic Prolactin Release
Bertram, R., Helena, C. V. V., González-Iglesias, A. E., Tabak, J., & Freeman, M. E. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02012.x · Cited by 28 · see citing works
Heesch, C. M., Zheng, H., Foley, C. M., Mueller, P. J., Hasser, E. M., & Patel, K. P. (2008) · Brain Research · doi:10.1016/j.brainres.2008.11.021 · Cited by 29 · see citing works
Thornton, S., Baldwin, P., Harris, P. A., Harding, F., Davison, J. M., Baylis, P. H., Timmons, P. M., & Wathes, D. C. (2002) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2002.01132.x · Cited by 29 · see citing works
Joushi, S., Esmaeilpour, K., Masoumi‐Ardakani, Y., Esmaeili‐Mahani, S., & Sheibani, V. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105044 · Cited by 28 · see citing works
Hormonal concentrations in bitches with primary uterine inertia
Bergström, A., Fransson, B. A., Lagerstedt, A., Kindahl, H., Olsson, U., & Olsson, K. (2010) · Theriogenology · doi:10.1016/j.theriogenology.2010.01.006 · Cited by 27 · see citing works
Blaustein, J. D. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00002-4 · Cited by 26 · see citing works
Dwyer, C. M., & Smith, L. A. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.08.007 · Cited by 24 · see citing works
Neurohypophysial Peptides in Cerebrospinal Fluid: An Update
Robinson, I. C. A. F., & Coombes, J. E. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb55553.x · Cited by 24 · see citing works
González, A., Mun˜oz, A., ̃oz, M. M., Marín, Ó., & Smeets, W. J. A. J. (1995) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(95)00063-d · Cited by 24 · see citing works
The Role of Oxytocin in Domestic Animal’s Maternal Care: Parturition, Bonding, and Lactation
Mota‐Rojas, D., Marcet‐Rius, M., Domínguez-Oliva, A., Martı́nez-Burnes, J., Lezama-García, K., Hernández-Ávalos, I., Rodríguez-González, D., & Bienboire‐Frosini, C. (2023) · Animals · doi:10.3390/ani13071207 · Cited by 23 · see citing works
Pathophysiological function of oxytocin secreted by neuropeptides: A mini review
Hashimoto, H., Uezono, Y., & Ueta, Y. (2012) · Pathophysiology · doi:10.1016/j.pathophys.2012.07.005 · Cited by 23 · see citing works
Nikolakopoulos, E., Kindahl, H., Gilbert, C. L., Goode, J. A., & Watson, E. D. (2000) · Animal Reproduction Science · doi:10.1016/s0378-4320(00)00149-4 · Cited by 23 · see citing works
Self-citationPolston, E. K., Centorino, K. M., & Erskine, M. S. (1998) · Endocrinology · doi:10.1210/endo.139.12.6341 · Cited by 23 · see citing works
Hashimoto, H., Onaka, T., Kawasaki, M., Chen, L., Mera, T., Soya, A., Saito, T., Fujihara, H., Séi, H., Morita, Y., et al. (2005) · Autonomic Neuroscience · doi:10.1016/j.autneu.2005.05.002 · Cited by 22 · see citing works
Yoo, K. Y., Jeong, C. W., Kang, M. W., Kim, S. J., Chung, S. T., Shin, M. H., & Lee, J. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318172c4d7 · Cited by 22 · see citing works
Campbell, M., & England, G. (2004) · Veterinary Record · doi:10.1136/vr.155.4.103 · Cited by 21 · see citing works
Balmuș, I.-M., Lefter, R. M., Ciobica, A. S., Antioch, I., Ababei, D. C., & Dobrin, R. (2018) · Psychiatria Danubina · doi:10.24869/psyd.2018.91 · Cited by 20 · see citing works
Gilbert, C. L., Boulton, M. I., Forsling, M. L., Goode, J. A., & McGrath, T. J. (1997) · Animal Reproduction Science · doi:10.1016/s0378-4320(96)01596-5 · Cited by 19 · see citing works
Self-citationPsychopharmacology of maternal behaviour
Keverne, E. B. (1996) · Journal of Psychopharmacology · doi:10.1177/026988119601000104 · Cited by 18 · see citing works
Self-citationJoushi, S., Taherizadeh, Z., Esmaeilpour, K., & Sheibani, V. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173318 · Cited by 18 · see citing works
Froemke, R. C., & Carcea, I. (2017) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-803506-1.00037-1 · Cited by 17 · see citing works
Houdeau, É., Raynal, P., Marnet, P., Germain, G., Mormède, P., Rossano, B., Monnerie, R., & Prud'homme, M.-J. (2002) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2002033 · Cited by 17 · see citing works
Peripartum effects of synthetic oxytocin: The good, the bad, and the unknown
Rashidi, M., Maier, E., Dekel, S., Sütterlin, M., Wolf, R. C., Ditzen, B., Grinevich, V., & Herpertz, S. C. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104859 · Cited by 18 · see citing works
The Role of the Oxytocin/Arginine Vasopressin System in Animal Models of Autism Spectrum Disorder
Zhang, R., Xu, X., Zhang, H.-F., Han, S., & Han, J. (2017) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-52498-6_8 · Cited by 16 · see citing works
Establishment of maternal bonding and its mediation by vaginocervical stimulation in goats
Romeyer, A., Poindron, P., Porter, R. H., Lévy, F., & Orgeur, P. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90153-8 · Cited by 16 · see citing works
Lévy, F. (2022) · Advances in neurobiology · doi:10.1007/978-3-030-97762-7_3 · Cited by 15 · see citing works
Induction of maternal behaviour in non-pregnant, hormone-primed ewes
Dwyer, C. M., & Lawrence, A. B. (1997) · Animal Science · doi:10.1017/s1357729800008602 · Cited by 15 · see citing works
- Authors
- Kendrick, K. M., Keverne, E. B., Hinton, M. R., & Goode, J. A.
- Affiliations
- University of Cambridge (GB)
- ORCID
- Kendrick, K.M.
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 1991-05
- Volume
- 26
- Issue
- 5
- Pages
- 803-807
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2059265899
- Cited by
- 128
- References
- 32
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 9 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 2
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, vasopressin, cerebrospinal fluid, plasma concentration, childbirth, vaginocervical stimulation, labor contractions, stress response, sheep
- MeSH terms
- Animals, Cervix Uteri, Female, Labor, Obstetric, Oxytocin, Pregnancy, Radioimmunoassay, Sheep, Vagina, Vasopressins
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