Cited by 4,987Olfactory and Sensory Function StudiesBiochemical Analysis and Sensing TechniquesIon Channels and Receptors

The DOI matches its Crossref record; 43 of the 45 references it cites were found in a registry or an index.

A novel multigene family may encode odorant receptors: A molecular basis for odor recognition

Open access

Buck, Linda, Axel, Richard·1991·Cell

DOI 10.1016/0092-8674(91)90418-x

Open this paper in CoChat — free account

Abstract

The mammalian olfactory system can recognize and discriminate a large number of different odorant molecules. The detection of chemically distinct odorants presumably results from the association of odorous ligands with specific receptors on olfactory sensory neurons. To address the problem of olfactory perception at a molecular level, we have cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium. The members of this novel gene family are likely to encode a diverse family of odorant receptors.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(91)90418-x

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
Somatic generation of antibody diversity.
Matthyssens, G., Hozumi, N., & Tonegawa, S. (1976) · PubMed · Cited by 3,237
Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments
Nathans, J., Thomas, D., & Hogness, D. S. (1986) · Science · doi:10.1126/science.2937147 · Cited by 1,732
Identification of a Family of Muscarinic Acetylcholine Receptor Genes
Bonner, T. I., Buckley, N. J., Young, A. C., & Brann, M. R. (1987) · Science · doi:10.1126/science.3037705 · Cited by 1,423
A cyclic nucleotide-gated conductance in olfactory receptor cilia
Nakamura, T., & Gold, G. H. (1987) · Nature · doi:10.1038/325442a0 · Cited by 1,154
Neurogenesis and neuron regeneration in the olfactory system of mammals. I. Morphological aspects of differentiation and structural organization of the olfactory sensory neurons
Graziadei, P. P. C., & Graziadei, G. A. M. (1979) · Journal of Neurocytology · doi:10.1007/bf01206454 · Cited by 1,006
G olf : an Olfactory Neuron Specific-G Protein Involved in Odorant Signal Transduction
Jones, D. T., & Reed, R. R. (1989) · Science · doi:10.1126/science.2499043 · Cited by 888
Chimeric α 2 -,β 2 -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity
Kobilka, B. K., Kobilka, T. S., Daniel, K. W., Regan, J. W., Caron, M. G., & Lefkowitz, R. J. (1988) · Science · doi:10.1126/science.2836950 · Cited by 763

Show all 45 references

Research works printed but not linked: 1

Rushton, 1965, Foveal photopigments in normal and colourblind, J. Physiol., 129, 41

Sorted by citations

Items 501–600 of 1,017

Chemosensory Functions for Pulmonary Neuroendocrine Cells
Gu, X., Karp, P. H., Brody, S. L., Pierce, R. A., Welsh, M. J., Holtzman, M. J., & Ben‐Shahar, Y. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0199oc · Cited by 158
Physiological factors contributing to the variability of sensory assessments: Relationship between salivary flow rate and temporal perception of gustatory stimuli
Fischer, U., Boulton, R. B., & Noble, A. C. (1994) · Food Quality and Preference · doi:10.1016/0950-3293(94)90008-6 · Cited by 155
Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees
Gilad, Y., Bustamante, C. D., Lancet, D., & Pääbo, S. (2003) · The American Journal of Human Genetics · doi:10.1086/378132 · Cited by 155
Single olfactory sensory neurons simultaneously integrate the components of an odour mixture
Duchamp‐Viret, P., Duchamp, A., & Chaput, M. A. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03001.x · Cited by 155
Prediction of the odorant binding site of olfactory receptor proteins by human–mouse comparisons
Man, O., Gilad, Y., & Lancet, D. (2003) · Protein Science · doi:10.1110/ps.03296404 · Cited by 155
Sensory processing in the main and accessory olfactory systems: Comparisons and contrasts
Meredith, M. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90258-7 · Cited by 155
Principles of Glomerular Organization in the Human Olfactory Bulb – Implications for Odor Processing
Maresh, A., Rodriguez‐Gil, D. J., Whitman, M. C., & Greer, C. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002640 · Cited by 154
How a well-adapted immune system is organized
Mayer, A., Balasubramanian, V., Mora, T., & Walczak, A. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421827112 · Cited by 154
Olfactory Neurons Expressing Closely Linked and Homologous Odorant Receptor Genes Tend to Project Their Axons to Neighboring Glomeruli on the Olfactory Bulb
Tsuboi, A., Yoshihara, S., Yamazaki, N., Kasai, H., Asai, H., Komatsu, M., Serizawa, S., Ishii, T., Matsuda, Y., Nagawa, F., et al. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08409.1999 · Cited by 154
Olfactory Discrimination Ability of Human Subjects for Ten Pairs of Enantiomers
Laska, M. (1999) · Chemical Senses · doi:10.1093/chemse/24.2.161 · Cited by 154
Crossmodal plasticity in sensory loss
Frasnelli, J., Collignon, O., Voss, P., & Leporé, F. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53752-2.00002-3 · Cited by 166
Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes
Malki, A., Fiedler, J., Fricke, K., Ballweg, I., Pfaffl, M. W., & Krautwurst, D. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.2a0714-331rr · Cited by 157
Evidence for MHC-correlated perfume preferences in humans
Milinski, M. (2001) · Behavioral Ecology · doi:10.1093/beheco/12.2.140 · Cited by 153
Effects of Second Intracellular Loop Mutations on Signal Transduction and Internalization of the Gonadotropin-releasing Hormone Receptor
Arora, K. K., Sakai, A., & Catt, K. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.39.22820 · Cited by 154
Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome
Nakagawa, T., Tanaka, Y., Matsuoka, E., Kondo, S., Okada, Y., Noda, Y., Kanai, Y., & Hirokawa, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9654 · Cited by 153
The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons
Hirota, J., & Mombaerts, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400940101 · Cited by 152
Target-independent pattern specification in the olfactory epithelium
Sullivan, S. L., Bohm, S., Ressler, K. J., Horowitz, L. F., & Buck, L. B. (1995) · Neuron · doi:10.1016/0896-6273(95)90170-1 · Cited by 152
Self-citation
Olfactory neurones expressing distinct odorant receptor subtypes are spatially segregated in the nasal neuroepithelium
Strotmann, J. M., Wanner, I. B., Helfrich, T., Beck, A., Meinken, C., Kubick, S., & Breer, H. (1994) · Cell and Tissue Research · doi:10.1007/bf00343941 · Cited by 152
Why Are Olfactory Systems of Different Animals So Similar?
Eisthen, H. L. (2002) · Brain Behavior and Evolution · doi:10.1159/000063564 · Cited by 151
Quantification of Odor Quality
Wise, P. M. (2000) · Chemical Senses · doi:10.1093/chemse/25.4.429 · Cited by 150
Current trends in `artificial-nose' technology
Dickinson, T. A., White, J., Kauer, J. S., & Walt, D. R. (1998) · Trends in biotechnology · doi:10.1016/s0167-7799(98)01185-8 · Cited by 150
A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1
Hsu, V. W., Shah, N., & Klausner, R. D. (1992) · Cell · doi:10.1016/0092-8674(92)90226-3 · Cited by 149
A family of non-GPCR chemosensors defines an alternative logic for mammalian olfaction
Greer, P. L., Bear, D. M., Lassance, J.-M., Bloom, M. L., Tsukahara, T., Pashkovski, S. L., Masuda, F. K., Nowlan, A. C., Kirchner, R., Hoekstra, H. E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.001 · Cited by 148
Functional Connectivity and Selective Odor Responses of Excitatory Local Interneurons in Drosophila Antennal Lobe
Huang, J., Zhang, W., Qiao, W., Hu, A., & Wang, Z. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.025 · Cited by 148
Cloning and localization of two multigene receptor families in goldfish olfactory epithelium
Cao, Y., Oh, B. C., & Stryer, L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11987 · Cited by 148
A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs)
Chun, J. J. M., Contos, J. J. A., & Munroe, D. G. (1999) · Cell Biochemistry and Biophysics · doi:10.1007/bf02738068 · Cited by 148
Biology and applications of olfactory sensing system: A review
Sankaran, S., Khot, L. R., & Panigrahi, S. (2012) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2012.03.029 · Cited by 155
Assessment of Upper Respiratory Tract and Ocular Irritative Effects of Volatile Chemicals in Humans
Doty, R. L., Cometto‐Muñiz, J. E., Jalowayski, A. A., Dalton, P., Kendal-Reed, M., & Hodgson, M. J. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490269586 · Cited by 147
Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability.
Strong, M., Chandy, K. G., & Gutman, G. A. (1993) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a039986 · Cited by 147
Representation of Natural Stimuli in the Rodent Main Olfactory Bulb
Lin, D., Shea, S. D., & Katz, L. C. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.021 · Cited by 147
Combinatorial Effects of Odorant Mixes in Olfactory Cortex
Zou, Z., & Buck, L. B. (2006) · Science · doi:10.1126/science.1124755 · Cited by 147
Self-citation
Retracted
Chaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics
Tao, Y., & Conn, P. M. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1121 · Cited by 149
Combinatorial effects of odorants on mouse behavior
Saraiva, L. R., Kondoh, K., Ye, X., Yoon, K.-H., Hernandez, M., & Buck, L. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605973113 · Cited by 151
Self-citation
INSECT OLFACTORY RECEPTORS: CONTRIBUTIONS OF MOLECULAR BIOLOGY TO CHEMICAL ECOLOGY
Jacquin‐Joly, E., & Merlin, C. (2004) · Journal of Chemical Ecology · doi:10.1007/s10886-004-7941-3 · Cited by 146
Molecular mechanisms underlying differential odor responses of a mouse olfactory receptor
Floriano, W. B., Vaidehi, N., Goddard, W. A., Singer, M. S., & Shepherd, G. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.10712 · Cited by 146
A novel olfactory receptor gene family in teleost fishPreprint
Saraiva, L. R., & Korsching, S. I. (2007) · Genome Research · doi:10.1101/gr.6553207 · Cited by 146
Learning-Dependent Structural Plasticity in the Adult Olfactory Pathway
Jones, S. V., Choi, D. C., Davis, M. E., & Ressler, K. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4465-08.2008 · Cited by 145
Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions
Fens, N., van der Schee, M. P., Brinkman, P., & Sterk, P. J. (2012) · Clinical & Experimental Allergy · doi:10.1111/cea.12052 · Cited by 145
Critical review of electronic nose and tongue instruments prospects in pharmaceutical analysis
Wasilewski, T., Migoń, D., Gębicki, J., & Kamysz, W. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.05.024 · Cited by 145
Imaging Odor-Induced Calcium Transients in Single Olfactory Cilia: Specificity of Activation and Role in Transduction
Leinders‐Zufall, T., Greer, C. A., Shepherd, G. M., & Zufall, F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-15-05630.1998 · Cited by 145
Odorant Receptor Expression Patterns Are Restored in Lesion-Recovered Rat Olfactory Epithelium
Iwema, C. L., Fang, H., Kurtz, D. B., Youngentob, S. L., & Schwob, J. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1219-03.2004 · Cited by 145
The role of the human senses in food acceptance
Cardello, A. V. (1996) · Springer eBooks · doi:10.1007/978-1-4613-1221-5_1 · Cited by 147
Large-scale transcriptional profiling of chemosensory neurons identifies receptor-ligand pairs in vivo
von der Weid, B., Rossier, D., Lindup, M., Tuberosa, J., Widmer, A., Col, J. D., Kan, C., Carleton, A., & Rodríguez, I. (2015) · Nature Neuroscience · doi:10.1038/nn.4100 · Cited by 144
Profound Context-Dependent Plasticity of Mitral Cell Responses in Olfactory Bulb
Doucette, W. T., & Restrepo, D. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060258 · Cited by 144
Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons
Monahan, K., Schieren, I., Cheung, J., Mumbey-Wafula, A., Monuki, E. S., & Lomvardas, S. (2017) · eLife · doi:10.7554/elife.28620 · Cited by 144
Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate
Norwood, J. N., Zhang, Q., Card, D., Craine, A., Ryan, T. M., & Drew, P. J. (2019) · eLife · doi:10.7554/elife.44278 · Cited by 145
Olfactory control of behavior in moths: central processing of odor information and the functional significance of olfactory glomeruli
Hildebrand, J. G. (1996) · Journal of Comparative Physiology A · doi:10.1007/bf00189586 · Cited by 144
Agonist-Independent GPCR Activity Regulates Anterior-Posterior Targeting of Olfactory Sensory Neurons
Nakashima, A., Takeuchi, H., Imai, T., Saito, H., Kiyonari, H., Abe, T., Chen, M., Weinstein, L. S., Yu, C. R., Storm, D. R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.033 · Cited by 143
Structural basis of odor sensing by insect heteromeric odorant receptors
Zhao, J., Chen, A. Q., Ryu, J., & del Mármol, J. I. (2024) · Science · doi:10.1126/science.adn6384 · Cited by 143
SIGNAL TRANSDUCTION IN THE CAENORHABDITIS ELEGANS NERVOUS SYSTEM
Bargmann, C. I., & Kaplan, J. M. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.279 · Cited by 143
Molecular messengers of olfaction
Ronnett, G. V., & Snyder, S. H. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90104-g · Cited by 143
Sensory food science in the changing society: Opportunities, needs, and challenges
Tuorila, H., & Monteleone, E. (2008) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2008.10.007 · Cited by 142
Extensive Copy-Number Variation of the Human Olfactory Receptor Gene Family
Young, J. M., Endicott, R. M., Parghi, S. S., Walker, M., Kidd, J. M., & Trask, B. J. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.07.005 · Cited by 146
Evidence for a peripheral olfactory memory in imprinted salmon.
Nevitt, G. A., Dittman, A. H., Quinn, T. P., & Moody, W. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4288 · Cited by 142
Asynchronous Onset of Odorant Receptor Expression in the Developing Zebrafish Olfactory System
Barth, A. L., Justice, N. J., & Ngai, J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80020-3 · Cited by 142
Molecular studies in insect olfaction
Field, L. M., Pickett, J. A., & Wadhams, L. J. (2000) · Insect Molecular Biology · doi:10.1046/j.1365-2583.2000.00221.x · Cited by 141
Regulation of the Probability of Mouse Odorant Receptor Gene Choice
Khan, M., Vaes, E., & Mombaerts, P. (2011) · Cell · doi:10.1016/j.cell.2011.09.049 · Cited by 143
Taste and smell processing in the brain
Rolls, E. T. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63855-7.00007-1 · Cited by 150
Calcium signalling and regulation in olfactory neurons
Menini, A. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80063-4 · Cited by 141
Toxoplasma gondii-altered host behaviour: clues as to mechanism of action
Webster, J. P., & McConkey, G. A. (2010) · Folia Parasitologica · doi:10.14411/fp.2010.012 · Cited by 140
Fundamental principles of the olfactory code
Grabe, V., & Sachse, S. (2017) · Biosystems · doi:10.1016/j.biosystems.2017.10.010 · Cited by 154
Recent advances in electronic and bioelectronic noses and their biomedical applications
Oh, E. H., Song, H. S., & Park, T. H. (2011) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2011.04.003 · Cited by 145
The sense of smell: molecular basis of odorant recognition
Zarzo, M. (2007) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2007.00019.x · Cited by 146
Chemical sensing of DNT by engineered olfactory yeast strain
Radhika, V., Proikas‐Cezanne, T., Jayaraman, M., Onésime, D., Ha, J. H., & Dhanasekaran, D. N. (2007) · Nature Chemical Biology · doi:10.1038/nchembio882 · Cited by 139
A mnemonic theory of odor perception.
Stevenson, R. J., & Boakes, R. A. (2003) · Psychological Review · doi:10.1037/0033-295x.110.2.340 · Cited by 139
Sequential Arrival and Graded Secretion of Sema3F by Olfactory Neuron Axons Specify Map Topography at the Bulb
Takeuchi, H., Inokuchi, K., Aoki, M., Suto, F., Tsuboi, A., Matsuda, I., Suzuki, M., Aiba, A., Serizawa, S., Yoshihara, Y., et al. (2010) · Cell · doi:10.1016/j.cell.2010.04.041 · Cited by 139
Evolutionary dynamics of olfactory receptor genes in chordates: interaction between environments and genomic contents
Niimura, Y. (2009) · Human Genomics · doi:10.1186/1479-7364-4-2-107 · Cited by 139
Review article: next generation diagnostic modalities in gastroenterology – gas phase volatile compound biomarker detection
Arasaradnam, R. P., Covington, J. A., Harmston, C., & Nwokolo, C. U. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12657 · Cited by 138
Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research
Sharma, A., Kumar, R., Aier, I., Semwal, R., Tyagi, P. K., & Varadwaj, P. K. (2018) · Current Neuropharmacology · doi:10.2174/1570159x17666181206095626 · Cited by 152
Synaptic organization of the glomerulus in the main olfactory bulb: Compartments of the glomerulus and heterogeneity of the periglomerular cells
Kosaka, K., & Kosaka, T. (2005) · Anatomical Science International · doi:10.1111/j.1447-073x.2005.00092.x · Cited by 138
Experience Modifies Olfactory Acuity: Acetylcholine-Dependent Learning Decreases Behavioral Generalization between Similar Odorants
Fletcher, M. L., & Wilson, D. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-j0005.2002 · Cited by 138
A comparison of the human and chimpanzee olfactory receptor gene repertoiresPreprint
Gilad, Y., Man, O., & Glusman, G. (2005) · Genome Research · doi:10.1101/gr.2846405 · Cited by 138
Metalloporphyrins based artificial olfactory receptors
Natale, C. D., Paolesse, R., & D’Amico, A. (2006) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2006.09.038 · Cited by 137
The Human Brain Project: neuroinformatics tools for integrating, searching and modeling multidisciplinary neuroscience data
Shepherd, G. M., Mirsky, J. S., Healy, M. D., Singer, M. S., Skoufos, E., Hines, M. S., Nadkarni, P. M., & Miller, P. L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01300-9 · Cited by 137
Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs)
Juilfs, D. M., Soderling, S. H., Burns, F., & Beavo, J. A. (2005) · Springer eBooks · doi:10.1007/bfb0033670 · Cited by 137
Efficient cell-free production of olfactory receptors: Detergent optimization, structure, and ligand binding analyses
Kaiser, L., Graveland-Bikker, J., Steuerwald, D., Vanberghem, M., Herlihy, K. M., & Zhang, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804766105 · Cited by 136
Memory formation in the absence of experience
Vetere, G., Tran, L. M., Moberg, S., Steadman, P. E., Restivo, L., Morrison, F. G., Ressler, K. J., Josselyn, S. A., & Frankland, P. W. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0389-0 · Cited by 148
Is the olfactory receptor a metalloprotein?
Wang, J., Luthey-Schulten, Z. A., & Suslick, K. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262792899 · Cited by 136
Olfactomedin: purification, characterization, and localization of a novel olfactory glycoprotein
Snyder, D. A., Rivers, A. M., Yokoe, H., Menco, B. P. M., & Anholt, R. R. H. (1991) · Biochemistry · doi:10.1021/bi00102a004 · Cited by 136
Differential Expansion of the N-Formylpeptide Receptor Gene Cluster in Human and Mouse
Gao, J., Chen, H., Filie, J. D., Kozak, C. A., & Murphy, P. M. (1998) · Genomics · doi:10.1006/geno.1998.5376 · Cited by 136
Organization of the olfactory pathway and odor processing in the antennal lobe of the ant Camponotus floridanus
Zube, C., Kleineidam, C. J., Kirschner, S., Neef, J., & Rößler, W. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21548 · Cited by 136
Topographic Representation of Odorant Molecular Features in the Rat Olfactory Bulb
Takahashi, Y. K., Kurosaki, M., Hirono, S., & Mori, K. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00236.2004 · Cited by 136
Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes
Bulger, M., van Doorninck, J. H., Saitoh, N., Telling, A., Farrell, C. M., Bender, M. A., Felsenfeld, G., Axel, R., & Groudine, M. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5129 · Cited by 136
Self-citation
Subpopulations of Projection Neurons in the Olfactory Bulb
Imamura, F., Ito, A., & LaFever, B. J. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.561822 · Cited by 143
Nested expression domains for odorant receptors in zebrafish olfactory epithelium
Weth, F., Nadler, W., & Korsching, S. I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13321 · Cited by 135
Olfactory receptors
Lancet, D., & Ben‐Arie, N. (1993) · Current Biology · doi:10.1016/0960-9822(93)90064-u · Cited by 135
Developmental Epigenetic Modification Regulates Stochastic Expression of Clustered Protocadherin Genes, Generating Single Neuron Diversity
Toyoda, S., Kawaguchi, M., Kobayashi, T., Tarusawa, E., Toyama, T., Okano, M., Oda, M., Nakauchi, H., Yoshimura, Y., Sanbo, M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.005 · Cited by 137
Acceleration of Olfactory Receptor Gene Loss in Primate Evolution: Possible Link to Anatomical Change in Sensory Systems and Dietary Transition
Niimura, Y., Matsui, A., & Touhara, K. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msy042 · Cited by 134
Electrical stimulation of cranial nerves in cognition and disease
Adair, D., Truong, D. Q., Esmaeilpour, Z., Gebodh, N., Borges, H., Ho, L., Bremner, J. D., Badran, B. W., Napadow, V., Clark, V. P., et al. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.02.019 · Cited by 136
Molecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo
Jiang, Y., Gong, N. N., Hu, X. S., Ni, M. J., Pasi, R., & Matsunami, H. (2015) · Nature Neuroscience · doi:10.1038/nn.4104 · Cited by 133
The Evolving Neural and Genetic Architecture of Vertebrate Olfaction
Bear, D. M., Lassance, J., Hoekstra, H. E., & Datta, S. R. (2016) · Current Biology · doi:10.1016/j.cub.2016.09.011 · Cited by 133
The Paired Homeodomain Protein DRG11 Is Required for the Projection of Cutaneous Sensory Afferent Fibers to the Dorsal Spinal Cord
Chen, Z., Rebelo, S., White, F. A., Malmberg, A. B., Baba, H., Lima, D., Woolf, C. J., Basbaum, A. I., & Anderson, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00341-5 · Cited by 134
A molecular dissection of spatial patterning in the olfactory system
Ressler, K. J., Sullivan, S. L., & Buck, L. B. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90061-2 · Cited by 133
Self-citation
Functional Diversity of ESC-Derived Motor Neuron Subtypes Revealed through Intraspinal Transplantation
Peljto, M., Dasen, J. S., Mazzoni, E. O., Jessell, T. M., & Wichterle, H. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.013 · Cited by 134
An Olfactory Subsystem that Mediates High-Sensitivity Detection of Volatile Amines
Pacifico, R., Dewan, A., Cawley, D., Guo, C., & Bozza, T. C. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.06.006 · Cited by 134
Functional Genomics Reveals Dysregulation of Cortical Olfactory Receptors in Parkinson Disease: Novel Putative Chemoreceptors in the Human Brain
Garcia‐Esparcia, P., Schlüter, A., Carmona, M., Moreno, J. R., Ansoleaga, B., Torrejón-Escribano, B., Gustincich, S., Pujol, A., & Ferrer, I. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318294fd76 · Cited by 132
Plasticity of the Human Olfactory System: The Olfactory Bulb
Huart, C., Rombaux, P., & Hummel, T. R. (2013) · Molecules · doi:10.3390/molecules180911586 · Cited by 146
The putative chemoreceptor families of C. elegans
Robertson, H. M. (2006) · WormBook · doi:10.1895/wormbook.1.66.1 · Cited by 132
Systematic review of the use of pheromones for treatment of undesirable behavior in cats and dogs
Frank, D., Beauchamp, G., & Palestrini, C. (2010) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.236.12.1308 · Cited by 131
International consensus statement on allergy and rhinology: Olfaction
Patel, Z. M., Holbrook, E. H., Turner, J. H., Adappa, N. D., Albers, M. W., Altundağ, A., Appenzeller, S., Costanzo, R. M., Croy, I., Davis, G. E., et al. (2022) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22929 · Cited by 142

Authors: Buck, L., & Axel, R.
Affiliations: Columbia University (US)
Howard Hughes Medical Institute (US)
ORCID: Buck, Linda
Axel, Richard
Venue: Cell
Publisher: Elsevier BV
Published: 1991-04
Volume: 65
Issue: 1
Pages: 175-187
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(91)90418-x
OpenAlex: W2097186487
Cited by: 4,987
References: 45
Citations by year: 2026: 90 · 2025: 176 · 2024: 185 · 2023: 162 · 2022: 165 · 2021: 150 · 2020: 207 · 2019: 163 · 2018: 149 · 2017: 171 · 2016: 182 · 2015: 212 · 2014: 176 · 2013: 186 · 2012: 159
FWCI: 60.14
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P01-CA23767, P01CA023767)
Topics: Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: olfactory receptors, gene family, olfactory sensory neurons, olfactory epithelium, seven-transmembrane proteins, odorant recognition, olfaction, gene cloning, ligand-gated receptors
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA, Biological Evolution, Multigene Family, Membrane Proteins, Molecular Sequence Data, Olfactory Pathways, Organ Specificity, Protein Conformation, Rats, Inbred Strains, Sensory Receptor Cells, Smell, Blotting, Southern, Blotting, Northern, Gene Expression, Polymerase Chain Reaction, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A novel multigene family may encode odorant receptors: A molecular basis for odor recognition

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks