Cited by 4,987Olfactory and Sensory Function StudiesBiochemical Analysis and Sensing TechniquesIon Channels and Receptors

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A novel multigene family may encode odorant receptors: A molecular basis for odor recognition

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Buck, Linda, Axel, Richard·1991·Cell

DOI 10.1016/0092-8674(91)90418-x

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Abstract

The mammalian olfactory system can recognize and discriminate a large number of different odorant molecules. The detection of chemically distinct odorants presumably results from the association of odorous ligands with specific receptors on olfactory sensory neurons. To address the problem of olfactory perception at a molecular level, we have cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium. The members of this novel gene family are likely to encode a diverse family of odorant receptors.

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Authors: Buck, L., & Axel, R.
Affiliations: Columbia University (US)
Howard Hughes Medical Institute (US)
ORCID: Buck, Linda
Axel, Richard
Venue: Cell
Publisher: Elsevier BV
Published: 1991-04
Volume: 65
Issue: 1
Pages: 175-187
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(91)90418-x
OpenAlex: W2097186487
Cited by: 4,987
References: 45
Citations by year: 2026: 90 · 2025: 176 · 2024: 185 · 2023: 162 · 2022: 165 · 2021: 150 · 2020: 207 · 2019: 163 · 2018: 149 · 2017: 171 · 2016: 182 · 2015: 212 · 2014: 176 · 2013: 186 · 2012: 159
FWCI: 60.14
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P01-CA23767, P01CA023767)
Topics: Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: olfactory receptors, gene family, olfactory sensory neurons, olfactory epithelium, seven-transmembrane proteins, odorant recognition, olfaction, gene cloning, ligand-gated receptors
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA, Biological Evolution, Multigene Family, Membrane Proteins, Molecular Sequence Data, Olfactory Pathways, Organ Specificity, Protein Conformation, Rats, Inbred Strains, Sensory Receptor Cells, Smell, Blotting, Southern, Blotting, Northern, Gene Expression, Polymerase Chain Reaction, Rats

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A novel multigene family may encode odorant receptors: A molecular basis for odor recognition

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