KSR, a novel protein kinase required for RAS signal transduction

Regulation of RAF protein kinases in ERK signalling

Lavoie, H., & Therrien, M. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3979 · Cited by 702

Targeting protein prenylation for cancer therapy

Berndt, N., Hamilton, A. D., & Sebti, S. M. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3151 · Cited by 614

Negative feedback regulation of the ERK1/2 MAPK pathway

Lake, D., Corrêa, S. A. L., & Müller, J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2297-8 · Cited by 565

RAF-MEK-ERK pathway in cancer evolution and treatment

Ullah, R., Yin, Q., Snell, A. H., & Wan, L. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.010 · Cited by 553

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

Jacobs, D., Glossip, D., Xing, H., Muslin, A. J., & Kornfeld, K. (1999) · Genes & Development · doi:10.1101/gad.13.2.163 · Cited by 439

Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

Ory, S., Zhou, M., Conrads, T. P., Veenstra, T. D., & Morrison, D. K. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00535-9 · Cited by 296

KSR modulates signal propagation within the MAPK cascade.

Therrien, M., Michaud, N. R., Rubin, G. M., & Morrison, D. K. (1996) · Genes & Development · doi:10.1101/gad.10.21.2684 · Cited by 257

KSR is a scaffold required for activation of the ERK/MAPK module

Roy, F., Laberge, G., Douziech, M., Ferland-McCollough, D., & Therrien, M. (2002) · Genes & Development · doi:10.1101/gad.962902 · Cited by 217

Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1.

Daga, A., Karlovich, C. A., Dumstrei, K., & Banerjee, U. (1996) · Genes & Development · doi:10.1101/gad.10.10.1194 · Cited by 188

RAS: Striking at the Core of the Oncogenic Circuitry

Gimple, R. C., & Wang, X. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00965 · Cited by 174

Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response

Pratilas, C. A., & Solit, D. B. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3064 · Cited by 183

The Major Vault Protein Is a Novel Substrate for the Tyrosine Phosphatase SHP-2 and Scaffold Protein in Epidermal Growth Factor Signaling

Kolli, S., Zito, C. I., Mossink, M. H., Wiemer, E. A. C., & Bennett, A. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313955200 · Cited by 154

Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic β cells

Khoo, S., Griffen, S. C., Xia, Y., Baer, R. J., German, M. S., & Cobb, M. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301198200 · Cited by 163

Signaling dynamics of the KSR1 scaffold complex

McKay, M. M., Ritt, D. A., & Morrison, D. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901590106 · Cited by 163

Ras/MAPK signaling from endomembranes

Fehrenbacher, N., Bar-Sagi, D., & Philips, M. (2009) · Molecular Oncology · doi:10.1016/j.molonc.2009.06.004 · Cited by 131

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1

Cullis, J., Meiri, D., Sandi, M. J., Radulovich, N., Kent, O. A., Medrano, M., Mokady, D., Normand, J., Larose, J., Marcotte, R., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.01.025 · Cited by 100

A CC-SAM, for Coiled Coil–Sterile α Motif, Domain Targets the Scaffold KSR-1 to Specific Sites in the Plasma Membrane

Koveal, D., Schuh-Nuhfer, N., Ritt, D., Page, R., Morrison, D. K., & Peti, W. (2012) · Science Signaling · doi:10.1126/scisignal.2003289 · Cited by 36

KSR induces RAS‐independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors

Paniagua, G., Jacob, H. K. C., Brehey, O., García‐Alonso, S., Lechuga, C. G., Pons, T., Musteanu, M., Guerra, C., Drosten, M., & Barbacid, M. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13213 · Cited by 34