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Cited by 941Redox biology and oxidative stressAntioxidant Activity and Oxidative StressFree Radicals and Antioxidants

The DOI matches its Crossref record; 602 of the 602 references it cites were found in a registry or an index.

The importance of free radicals and catalytic metal ions in human diseases.

Halliwell, Barry, Gutteridge, John M.C.·1985·Molecular Aspects of Medicine
DOI 10.1016/0098-2997(85)90001-9
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Abstract

The study of free radical reactions is not an isolated and esoteric branch of science. A knowledge of free radical chemistry and biochemistry is relevant to an understanding of all diseases and the mode of action of all toxins, if only because diseased or damaged tissues undergo radical reactions more readily than do normal tissues. However it does not follow that because radical reactions can be demonstrated, they are important in any particular instance. We hope that the careful techniques needed to assess the biological role of free radicals will become more widely used.

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Crossref · 10.1016/0098-2997(85)90001-9

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Citations

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Research works printed but not linked: 12

  1. Bannister, 1984, The effect of ferritin iron loading on hydroxyl radical production, Life Chem. Rep., 2, 64
  2. Cohen, 1983, Catalase, glutathione peroxidase, superoxide dismutase and cytochrome P450, Vol. 4, 315
  3. Cranton, 1984, Free radical pathology in age-associated diseases: treatment with EDTA chelation, nutrition and antioxidants, J. Holistic Med., 6, 6
  4. Creeth, 1982, Mucoglycoproteins: scission at specific sites on the peptide backbone, IRCS Med. Sci., 10, 548
  5. Czapski, 1985, When do metal complexes protect biological systems from superoxide toxicity and when do they enhance it?, Free Rad. Res. Commun.
  6. Fridovich, 1974, Superoxide dismutases, Adv. Enzymol., 41, 35
  7. Lewis, 1984, Inactive forms of plasma antiproteases in arthritic synovial fluids, IRCS Med. Sci., 12, 304
  8. McCord, 1979, Superoxide radical as a phagocyte-produced chemical mediator of inflammation, Adv. Inflamm. Res., 1, 273
  9. Oberley, 1979, Role of superoxide dismutase in cancer, Cancer Res., 39, 1141
  10. Richardson, 1983, Iron fortification of food and drinks, Chem. Ind., 4, 498
  11. Skalka, 1984, Chromatin and free radicals generated by various agents: spacer-DNA specific damage by some cancerostatic antibiotics, Stud. Biophys., 104, 257
  12. Youngman, 1983, The photodynamic generation of singlet molecular oxygen by the fungal toxin cercosporin, Photobiochem. Photobiophys., 6, 109

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Metadata

Authors
Halliwell, B., & Gutteridge, J. M. C.
Affiliations
University of London (GB)
ORCID
Halliwell, Barry
Venue
Molecular Aspects of Medicine
Publisher
Elsevier BV
Published
1985-01
Volume
8
Issue
2
Pages
89-193
ISSN
0098-2997 (ISSN-L)
DOI
10.1016/0098-2997(85)90001-9
OpenAlex
W2069471046
Cited by
941
References
602
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 14 · 2022: 19 · 2021: 9 · 2020: 26 · 2019: 18 · 2018: 10 · 2017: 15 · 2016: 16 · 2015: 26 · 2014: 17 · 2013: 28 · 2012: 20
FWCI
5.45
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Molecular Aspects of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords
free radicals, catalytic metal ions, radical reactions, human disease, toxins, tissue damage, oxidative stress
MeSH terms
Aging, Autoimmune Diseases, Brain Ischemia, Copper, Coronary Disease, Disease, Physical Exertion, Free Radicals, Humans, Intestines, Iron, Ischemia, Joint Diseases, Lipid Peroxides, Malaria, Metals, Neoplasms, Nervous System Diseases, Respiratory Distress Syndrome

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