Cited by 941Redox biology and oxidative stressAntioxidant Activity and Oxidative StressFree Radicals and Antioxidants

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The importance of free radicals and catalytic metal ions in human diseases.

Halliwell, Barry, Gutteridge, John M.C.·1985·Molecular Aspects of Medicine

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Abstract

The study of free radical reactions is not an isolated and esoteric branch of science. A knowledge of free radical chemistry and biochemistry is relevant to an understanding of all diseases and the mode of action of all toxins, if only because diseased or damaged tissues undergo radical reactions more readily than do normal tissues. However it does not follow that because radical reactions can be demonstrated, they are important in any particular instance. We hope that the careful techniques needed to assess the biological role of free radicals will become more widely used.

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Flitter, W. D., Rowley, D. A., & Halliwell, B. B. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80602-4 · Cited by 281
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Generation of Hydroxyl Radical by Enzymes, Chemicals, and Human Phagocytes In Vitro
Repine, J. E., Eaton, J. W., Anders, M. W., Hoidal, J. R., & Fox, R. B. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109626 · Cited by 280
The production of free radicals during the autoxidation of cysteine and their effect on isolated rat hepatocytes
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Repine, J. E., Fox, R. B., & Berger, E. M. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68927-1 · Cited by 279
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Doxorubicin-dependent lipid peroxidation at low partial pressures of O2
Winterbourn, C. C., Gutteridge, J. M. C., & Halliwell, B. B. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90028-5 · Cited by 272
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Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia
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Lipid peroxide formation in microsomes. The role of non-haem iron
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Mutagenicity of oxygen free radicals.
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OCULAR TOXICITY OF HIGH-DOSE INTRAVENOUS DESFERRIOXAMINE
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Low-molecular-weight iron complexes and oxygen radical reactions in idiopathic haemochromatosis
Gutteridge, J. M. C., Rowley, D. A., Griffiths, E., & Halliwell, B. B. (1985) · Clinical Science · doi:10.1042/cs0680463 · Cited by 269
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Analytical Applications of Bioluminescence and Chemiluminescence
Chappelle, E. W., & Picciolo, G. L. (1975) · NASA Technical Reports Server (NASA) · Cited by 266
Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals
Winterbourn, C. C. (1979) · Biochemical Journal · doi:10.1042/bj1820625 · Cited by 266
LIPID PEROXIDATION AND FLUORESCENT MOLECULAR DAMAGE TO MEMBRANES
Tappel, A. L. (1975) · Elsevier eBooks · doi:10.1016/b978-0-12-701501-9.50008-8 · Cited by 265
Siderophore mediated absorption of iron
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Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells
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Mutation Caused by Human Phagocytes
Weitzman, S. A., & Stossel, T. P. (1981) · Science · doi:10.1126/science.6259738 · Cited by 259
Chronic Granulomatous Disease
Tauber, A. I., Borregaard, N., Simons, E. R., & Wright, J. (1983) · Medicine · doi:10.1097/00005792-198309000-00003 · Cited by 257
Aldehydes in biological systems
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Lipid peroxidation: its measurement, occurrence, and significance in animal tissues.
Barber, A. A., & Bernheim, F. (1967) · PubMed · Cited by 253
Inhibition of lipid peroxidation by the iron-binding protein lactoferrin
Gutteridge, J. M. C., Paterson, S., Segal, A. W., & Halliwell, B. B. (1981) · Biochemical Journal · doi:10.1042/bj1990259 · Cited by 252
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Inhibition of Tumor Promotion by a Biomimetic Superoxide Dismutase
Kensler, T. W., Bush, D. M., & Kozumbo, W. J. (1983) · Science · doi:10.1126/science.6857269 · Cited by 252
DNA Strand Breakage in Human Leukocytes Exposed to a Tumor Promoter, Phorbol Myristate Acetate
Birnboim, H. C. (1982) · Science · doi:10.1126/science.6276978 · Cited by 250
Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450.
Ingelman‐Sundberg, M., & Johansson, I. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82163-2 · Cited by 249
FREE RADICAL BIOLOGY: XENOBIOTICS, CANCER, AND AGING*
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Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.
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Hydroxyl radical production in body fluids Roles of metal ions, ascorbate and superoxide
Winterbourn, C. C. (1981) · Biochemical Journal · doi:10.1042/bj1980125 · Cited by 247
Copper salt-dependent hydroxyl radical formation
Gutteridge, J. M. C., & Wilkins, S. (1983) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(83)90186-1 · Cited by 243
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The Role of Oxygen-free Radicals in Ischemic Tissue Injury in Island Skin Flaps
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Thiobarbituric acid test for detecting lipid peroxides
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Unusual copper-induced sensitization of the biological damage due to superoxide radicals.
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The thiobarbituric acid test for lipid peroxidation: Structure of the adduct with malondialdehyde
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ANTIOXIDANT PROTECTION: A FUNCTION OF TRACHEOBRONCHIAL AND GASTROINTESTINAL MUCUS
Cross, C. E., Halliwell, B. B., & Allen, A. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91822-1 · Cited by 234
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The Role of Iron in Enzymatic Lipid Peroxidation
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The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron
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Oxidant damage mediates variant red cell resistance to malaria
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Superoxide-dependent formation of hydroxyl radicals: Detection of hydroxyl radicals by the hydroxylation of aromatic compounds
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Sterol metabolism. XXV. Cholesterol oxidation by singlet molecular oxygen
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Lipid peroxidation in rheumatoid arthritis: Thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients
Rowley, D. A., Gutteridge, J. M. C., Blake, D. R., Farrs, M., & Halliwell, B. B. (1984) · Clinical Science · doi:10.1042/cs0660691 · Cited by 225
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Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Oown's syndrome fetal brain
Brooksbank, B. W. L., & Balázs, R. (1984) · Developmental Brain Research · doi:10.1016/0165-3806(84)90060-9 · Cited by 224
Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of ‘catalytic’ iron and anti-oxidant activity in extracellular fluids
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Caeruloplasmin: Physiological and Pathological Perspectives
Gutteridge, J. M. C., & Stocks, J. (1981) · CRC Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408368109105866 · Cited by 217
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CNS receptors: From molecular pharmacology to behavior
MandelDefeudis (1983) · Cited by 217
Antioxidant properties of the proteins caeruloplasmin, albumin and transferrin. A study of their activity in serum and synovial fluid from patients with rheumatoid arthritis
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Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline-perfused rabbit lungs.
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Intra- and extracellular events in luminol-dependent chemiluminescence of polymorphonuclear leukocytes
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Glutathione and Ascorbate During Ischemia and Postischemic Reperfusion in Rat Brain
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THE QUENCHING OF SINGLET OXYGEN BY AMINO ACIDS AND PROTEINS
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Superoxide‐dependent formation of hydroxyl radicals in the presence of thiol compounds
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Inhibition of surgically induced ischemia/reperfusion injury by oxygen free radical scavengers
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The Toxicology of Molecular Oxygen
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Metabolism of Oxygen Derivatives in Down's Syndrome*
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Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: A physiologically significant reaction?
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The Use of Deferoxamine in the Management of Aluminum Accumulation in Bone in Patients with Renal Failure
Malluche, H. H., Smith, A. J., Abreo, K., & Faugere, M.-C. (1984) · New England Journal of Medicine · doi:10.1056/nejm198407193110302 · Cited by 199
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Inhibition of collagen gelation by action of the superoxide radical
Greenwald, R. A., & Moy, W. W. (1979) · Arthritis & Rheumatism · doi:10.1002/art.1780220307 · Cited by 196
Ascorbic acid, metal ions and the superoxide radical
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Reduction of myocardial ischemic injury with oxygen-derived free radical scavengers.
Gardner, T. J., Stewart, J. R., Casale, A. S., Downey, J. M., & De, C. (1983) · PubMed · Cited by 193
Free-radical damage to lipids, amino acids, carbohydrates and nucleic acids determined by thiobarbituric acid reactivity
Gutteridge, J. M. C. (1982) · International Journal of Biochemistry · doi:10.1016/0020-711x(82)90050-7 · Cited by 192
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Xanthine oxidase type D (dehydrogenase) in the intestine and other organs of the rat
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Oxygen radicals in the adult respiratory distress syndrome, in myocardial ischemia and reperfusion injury, and in cerebral vascular damage
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Iron Overload Disorders: Natural History, Pathogenesis, Diagnosis, and Therapy
McLaren, G. D., Muir, W., Kellermeyer, R. W., & Jacobs, A. (1983) · CRC Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408368309165764 · Cited by 189
Lipid peroxidation and acute lung injury after thermal trauma to skin. Evidence of a role for hydroxyl radical.
Till, G. O., Hatherill, J. R., Tourtellotte, W. W., Lutz, M. J., & Ward, P. A. (1985) · PubMed Central · Cited by 188
The Inhibition of Lipid Autoxidation by Human Serum and its Relation to Serum Proteins and α-Tocopherol
Stocks, J., Gutteridge, J. M. C., Sharp, R. J., & Dormandy, T. L. (1974) · Clinical Science · doi:10.1042/cs0470223 · Cited by 187
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IRON, COPPER, ZINC, AND MANGANESE IN MILK
Lönnerdal, B., Keen, C. L., & Hurley, L. S. (1981) · Annual Review of Nutrition · doi:10.1146/annurev.nu.01.070181.001053 · Cited by 186
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Cerebral and Ocular Toxicity Induced by Desferrioxamine
Blake, D. R., Winyard, P. G., Lunec, J., Williams, A. C., Good, P. A., Crewes, S. J., Gutteridge, J. M. C., ROWLEY, D., Halliwell, B. B., Cornish, A. L., et al. (1985) · QJM · doi:10.1093/oxfordjournals.qjmed.a067880 · Cited by 180
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The role of superoxide and hydroxyl radicals in the degradation of hyaluronic acid induced by metal ions and by ascorbic acid
Wong, F. S., Halliwell, B. B., Richmond, R., & Skowroneck, W. R. (1981) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(00)80033-1 · Cited by 180
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Isoprene — The main hydrocarbon in human breath
Gelmont, D. M., Stein, R. A., & Mead, J. F. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(81)90782-8 · Cited by 177
Free radicals and singlet oxygen scavengers: Reaction of a peroxy-radical with β-carotene, diphenyl furan and 1,4-diazobicyclo(2,2,2)-octane
Packer, J. E., Mahood, J. S., Mora-Arellano, V. O., Slater, T. F., WILLSON, R. L., & Wolfenden, B. S. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(81)91196-7 · Cited by 176
Superoxide dismutase activity of low molecular weight Cu2+‐chelates studied by pulse radiolysis
Brigelius, R., Spöttl, R., Bors, W., Lengfelder, E., Sarán, M., & Weser, U. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80428-x · Cited by 170
MEASUREMENT OF AND PROTECTION FROM IN VIVO LIPID PEROXIDATION
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Production of active oxygen species (1O2 and O2⨪) by psoralens and ultraviolet radiation (320–400 nm)
Pathak, M. A., & Joshi, P. C. (1984) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(84)90018-7 · Cited by 168
Protection Against Lethal Hyperoxia by Tracheal Insufflation of Erythrocytes: Role of Red Cell Glutathione
van Asbeck, B. S., Hoidal, J. R., Vercellotti, G. M., Schwartz, B. A., Moldow, C. F., & Jacob, H. S. (1985) · Science · doi:10.1126/science.2982213 · Cited by 167
Lactoferrin Deficiency Associated with Altered Granulocyte Function
Boxer, L. A., Coates, T. D., Haak, R. A., Wolach, J. B., Hoffstein, S. T., & Baehner, R. L. (1982) · New England Journal of Medicine · doi:10.1056/nejm198208123070704 · Cited by 166
Selenium, Vitamin E and the Response to Swimming Stress in the Rat
Brady, P. S., Brady, L. J., & Ullrey, D. E. (1979) · Journal of Nutrition · doi:10.1093/jn/109.6.1103 · Cited by 166
The analogous mechanisms of enzymatic inactivation induced by ascorbate and superoxide in the presence of copper.
Shinar, E., Navok, T., & Chevion, M. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43728-8 · Cited by 165
Malondialdehyde formation from lipid peroxides in the thiobarbituric acid test: the role of lipid radicals, iron salts, and metal chelators.
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A non-transferrin-bound serum iron in idiopathic hemochromatosis
Batey, R. G., Fong, P. L. C., Shamir, S., & Sherlock, S. (1980) · Digestive Diseases and Sciences · doi:10.1007/bf01308057 · Cited by 162
The production of hydroxyl and superoxide radicals by stimulated human neutrophils — measurements by EPR spectroscopy
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Vitamin C and Iron
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Cobalt(II) ion as a promoter of hydroxyl radical and possible ‘crypto-hydroxyl’ radical formation under physiological conditions. Differential effects of hydroxyl radical scavengers
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Urinary malondialdehyde as an indicator of lipid peroxidation in the diet and in the tissues
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Ethylene formation from methional
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CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856
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Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
Dexter, D. T., Wells, F. R., Lee, A. J., Agid, F., Agid, Y., Jenner, P., & Marsden, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07264.x · Cited by 1,149

See all 941

Authors: Halliwell, B., & Gutteridge, J. M. C.
Affiliations: University of London (GB)
ORCID: Halliwell, Barry
Venue: Molecular Aspects of Medicine
Publisher: Elsevier BV
Published: 1985-01
Volume: 8
Issue: 2
Pages: 89-193
ISSN: 0098-2997 (ISSN-L)
DOI: 10.1016/0098-2997(85)90001-9
OpenAlex: W2069471046
Cited by: 941
References: 602
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 14 · 2022: 19 · 2021: 9 · 2020: 26 · 2019: 18 · 2018: 10 · 2017: 15 · 2016: 16 · 2015: 26 · 2014: 17 · 2013: 28 · 2012: 20
FWCI: 5.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Aspects of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords: free radicals, catalytic metal ions, radical reactions, human disease, toxins, tissue damage, oxidative stress
MeSH terms: Aging, Autoimmune Diseases, Brain Ischemia, Copper, Coronary Disease, Disease, Physical Exertion, Free Radicals, Humans, Intestines, Iron, Ischemia, Joint Diseases, Lipid Peroxides, Malaria, Metals, Neoplasms, Nervous System Diseases, Respiratory Distress Syndrome

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The importance of free radicals and catalytic metal ions in human diseases.

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