The DOI matches its Crossref record; 602 of the 602 references it cites were found in a registry or an index.
The importance of free radicals and catalytic metal ions in human diseases.
Abstract
The study of free radical reactions is not an isolated and esoteric branch of science. A knowledge of free radical chemistry and biochemistry is relevant to an understanding of all diseases and the mode of action of all toxins, if only because diseased or damaged tissues undergo radical reactions more readily than do normal tissues. However it does not follow that because radical reactions can be demonstrated, they are important in any particular instance. We hope that the careful techniques needed to assess the biological role of free radicals will become more widely used.
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“Fe2+ also has the potential to generate damaging reactive oxygen species (ROS) via Fenton/Haber Weiss chemistry [5]”
From Host Iron Withholding Demands Siderophore Utilization for Candida glabrata to Survive Macrophage Killing (2011) · cites this paper as [5]
Citations
Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Self-citationHydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
Oxygen toxicity, oxygen radicals, transition metals and disease
Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330
Self-citationFridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329
Prooxidant States and Tumor Promotion
Cerutti, P. (1985) · Science · doi:10.1126/science.2981433 · Cited by 2,513
Fridovich, I. (1975) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.44.070175.001051 · Cited by 1,753
Free radicals and tissue damage produced by exercise
Davies, K. J. A., Quintanilha, A. T., Brooks, G. A., & Packer, L. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(82)80124-1 · Cited by 1,739
Free Radical Mechanisms in Tissue Injury
Slater, T. F. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0813-3_18 · Cited by 1,555
Free-radical mechanisms in tissue injury
Slater, T. F. (1984) · Biochemical Journal · doi:10.1042/bj2220001 · Cited by 1,542
Research works printed but not linked: 12
- Bannister, 1984, The effect of ferritin iron loading on hydroxyl radical production, Life Chem. Rep., 2, 64
- Cohen, 1983, Catalase, glutathione peroxidase, superoxide dismutase and cytochrome P450, Vol. 4, 315
- Cranton, 1984, Free radical pathology in age-associated diseases: treatment with EDTA chelation, nutrition and antioxidants, J. Holistic Med., 6, 6
- Creeth, 1982, Mucoglycoproteins: scission at specific sites on the peptide backbone, IRCS Med. Sci., 10, 548
- Czapski, 1985, When do metal complexes protect biological systems from superoxide toxicity and when do they enhance it?, Free Rad. Res. Commun.
- Fridovich, 1974, Superoxide dismutases, Adv. Enzymol., 41, 35
- Lewis, 1984, Inactive forms of plasma antiproteases in arthritic synovial fluids, IRCS Med. Sci., 12, 304
- McCord, 1979, Superoxide radical as a phagocyte-produced chemical mediator of inflammation, Adv. Inflamm. Res., 1, 273
- Oberley, 1979, Role of superoxide dismutase in cancer, Cancer Res., 39, 1141
- Richardson, 1983, Iron fortification of food and drinks, Chem. Ind., 4, 498
- Skalka, 1984, Chromatin and free radicals generated by various agents: spacer-DNA specific damage by some cancerostatic antibiotics, Stud. Biophys., 104, 257
- Youngman, 1983, The photodynamic generation of singlet molecular oxygen by the fungal toxin cercosporin, Photobiochem. Photobiophys., 6, 109
Cited by
Sorted by citations
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Self-citationThe Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00140-5 · Cited by 2,051
Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
Halliwell, B., & Gutteridge, J. M. C. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90305-x · Cited by 2,038
Self-citationOxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856
Self-citationDexter, D. T., Wells, F. R., Lee, A. J., Agid, F., Agid, Y., Jenner, P., & Marsden, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07264.x · Cited by 1,149
Metadata
- Authors
- Halliwell, B., & Gutteridge, J. M. C.
- Affiliations
- University of London (GB)
- ORCID
- Halliwell, Barry
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 1985-01
- Volume
- 8
- Issue
- 2
- Pages
- 89-193
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W2069471046
- Cited by
- 941
- References
- 602
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 14 · 2022: 19 · 2021: 9 · 2020: 26 · 2019: 18 · 2018: 10 · 2017: 15 · 2016: 16 · 2015: 26 · 2014: 17 · 2013: 28 · 2012: 20
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Aspects of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- free radicals, catalytic metal ions, radical reactions, human disease, toxins, tissue damage, oxidative stress
- MeSH terms
- Aging, Autoimmune Diseases, Brain Ischemia, Copper, Coronary Disease, Disease, Physical Exertion, Free Radicals, Humans, Intestines, Iron, Ischemia, Joint Diseases, Lipid Peroxides, Malaria, Metals, Neoplasms, Nervous System Diseases, Respiratory Distress Syndrome
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