Interactions between ubiquinones and vitamins in membranes and cells
Abstract
The interaction between ubiquinones and vitamin E was studied in the inner membranes of rat liver mitochondria, liposomes and human erythrocyte plasma membranes. Free radicals were produced by addition of exogenous oxidants, and their reaction with chromanols and ubiquinone was followed by ESR and HPLC. Membranes were made deficient in ubiquinone but sufficient in alpha-tocopherol and were reconstituted with added ubiquinone. With these membrane preparations it was shown that (i) in the inner mitochondrial membranes there is a requirements for ubiquinone in the enzymatic recycling of vitamin E; (ii) succinate-ubiquinone reductase incorporated in liposomes cannot protect vitamin E in the absence of ubiquinone and (iii) in human erythrocyte plasma membranes protection against the loss of vitamin E can be provided by NADH-cytochrome-b5-dependent enzymatic recycling. We conclude that ubiquinonols (ubisemiquinones) reduce vitamin E through electron transport.
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The antioxidant properties of CoQ are not due to direct scavenging of superoxide but appear to be mediated through regeneration of active ascorbic acid and tocopherol.
“The antioxidant properties of CoQ are not due to direct scavenging of superoxide but appear to be mediated through regeneration of active ascorbic acid and tocopherol, the reduced from of vitamin E (66).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [66]
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- Authors
- Constantinescu, A., Maguire, J. J., & Packer, L.
- Affiliations
- University of California, Berkeley (US)
- Lawrence Berkeley National Laboratory (US)
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 1994-01
- Volume
- 15
- Pages
- s57-s65
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W2052012292
- Cited by
- 73
- References
- 22
- Citations by year
- 2024: 1 · 2023: 3 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 5 · 2013: 3 · 2012: 2
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Aspects of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca047597-05)
- National Cancer Institute (CA 47597)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- coenzyme Q10, vitamin E, alpha-tocopherol, lipid peroxidation, free radicals, inner mitochondrial membrane, liver mitochondria, liposomes, erythrocyte plasma membrane, succinate-ubiquinone reductase, NADH-cytochrome b5 reductase, electron transport, ubiquinone deficiency
- MeSH terms
- Animals, Cell Membrane, Chromans, Chromatography, High Pressure Liquid, Drug Interactions, Electron Spin Resonance Spectroscopy, Electron Transport, Erythrocyte Membrane, Eukaryotic Cells, Free Radicals, Humans, Intracellular Membranes, Liposomes, Mitochondria, Liver, Multienzyme Complexes, NAD, Oxidoreductases, Succinate Dehydrogenase, Succinates, Ubiquinone, Vitamin E, Succinic Acid, Electron Transport Complex II, Rats
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