Effect of coenzyme Q 10 supplementation on statin-induced myalgia, a randomized double-blind, placebo-controlled study
Open accessAbstract
Objective: Statins are highly effective medications for reducing low-density lipoprotein cholesterol concentrations and cardiovascular events.Their most common side effects are a variety of myopathic complaints, possibly due to reduced circulating Coenzyme Q10 (CoQ10) levels.We sought to determine whether CoQ10 supplementation decreases the rate of myalgia in patients with statin-related myalgia.Methods: Patients treated with a statin for clinical indications who reported statin induced myalgia were eligible.Patients were randomized to treatment with CoQ10 120 mg/day (17 patients) or placebo (20 patients) in a double-blind manner.Treatment was continued for 12 weeks.All patients were instructed to continue taking their prescribed statin as usual.Myalgia score was assessed before intervention and then weekly, for 12 weeks of therapy, using a visual analogue scale (VAS).Results: Over 12 weeks of treatment, myalgia score gradually decreased in both the treatment group and placebo group to the same extent (from 6.2 to 3.3 in the treatment group and from 5.9 to 3.1 in the placebo group), without significant differences between the groups.No significant change was noted between the two groups in the number of patients tolerated statin therapy.Conclusions: CoQ10 does not appear to decrease the rate of myalgia when compared to placebo in patients with statin-related myalgia.
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Only two included studies reported an intention-to-treat analysis.
“Only two studies reported an intention to treat analysis and this had to be assumed for the other studies when using the RoB2tool [9,11].”
From Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis (2020) · cites this paper as [11]
The passage labeled Conclusion states that this trial’s primary analysis was by intention-to-treat. It does not establish that only two studies in the citing review reported such an analysis, or that the other studies required an assumption for RoB 2. (LLM, conf=0.85)
Experimental — accuracy not yet measuredAll included studies were randomised controlled trials designed as parallel-group studies with a placebo arm.
“All included studies were RCTs designed as parallel-group studies with a placebo arm [5,6,8,9,11,12,17].”
From Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis (2020) · cites this paper as [11]
A number of randomised controlled trials have reported that CoQ10 reduces statin-associated muscle symptoms, while others have failed to demonstrate a benefit.
“A number of these RCTs have reported that CoQ10 reduces SAMS [4-7], while other have failed to demonstrate a benefit [8-12].”
From Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis (2020) · cites this paper as [11]
One included study had CoQ10 supplied by a company.
“one had the CoQ10 supplied by a company [11]”
From Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis (2020) · cites this paper as [11]
Seven studies with 321 patients were included in the pooled analysis, of which 165 were treated with CoQ10 and 156 with placebo.
“Seven studies with 321 patients were included in the pooled analysis, of which 165 were treated with CoQ10 and 156 with placebo [5,6,8,9,11,12,17].”
From Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis (2020) · cites this paper as [11]
For the second outcome of interest, three studies with 79 CoQ10-treated patients and 78 placebo-controlled comparators were included.
“For the second outcome of interest, three studies with 79 CoQ10 treated patients and 78 placebo controlled comparators were included [8,9,11].”
From Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis (2020) · cites this paper as [11]
Three trials assessed statin continuation at the end of the study period.
“Three trials assessed statin continuation at the end of the study period [8,9,11].”
From Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis (2020) · cites this paper as [11]
A number of included studies reported attrition of patients but did not describe baseline characteristics or interval outcomes.
“A number of studies reported the attrition of patients but did not describe their baseline characteristics or interval outcomes [8,9,11,12].”
From Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis (2020) · cites this paper as [11]
In one study the baseline myalgia scores varied by almost 25%, and by 5-10% in two others.
“In one study the baseline scores varied by almost 25% [24] and by 5-10% in two others [6,11].”
From Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis (2020) · cites this paper as [11]
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Cites
Thompson, P. D., Clarkson, P., & Karas, R. H. (2003) · JAMA · doi:10.1001/jama.289.13.1681 · Cited by 1,463 · see citing works
Statin-associated myopathy with normal creatine kinase levels
Phillips, P. S., Haas, R. H., Bannykh, S., Hathaway, S., Gray, N. L., Kimura, B. J., Vladutiu, G. D., England, J. D. F., & and the Scripps Mercy Clinical Research Center* (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-7-200210010-00009 · Cited by 565 · see citing works
Lovastatin decreases coenzyme Q levels in humans.
Folkers, K., Langsjoen, P. H., Willis, R. A., Richardson, P. C., Xia, L., Ye, C. Q., & Tamagawa, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.8931 · Cited by 426 · see citing works
Ghirlanda, G., Oradei, A., Manto, A., Lippa, S., Uccioli, L., Caputo, S., Greco, A. V., & Littarru, G. P. (1993) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1993.tb03948.x · Cited by 324 · see citing works
Antioxidant and prooxidant properties of mitochondrial Coenzyme Q
James, A. M., Smith, R. A. J., & Murphy, M. P. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.025 · Cited by 292 · see citing works
Effect of Coenzyme Q10 on myopathic symptoms in patients treated with statins
Caso, G., Kelly, P., McNurlan, M. A., & Lawson, W. E. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.12.063 · Cited by 286 · see citing works
The Powerful Placebo: From Ancient Priest to Modern Physician
Shapiro, A. K., & Shapiro, E. (1997) · Cited by 246 · see citing works
Davidson, M. H., McKenney, J. M., Stein, E. A., Schrott, H. G., Bakker-Arkema, R. G., Fayyad, R. S., & Black, D. M. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00174-4 · Cited by 233 · see citing works
A randomized trial of Coenzyme Q10 in patients with confirmed statin myopathy
Taylor, B. A., Lorson, L., White, C. M., & Thompson, P. D. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.12.016 · Cited by 200 · see citing works
Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors
Mortensen, S. A., Leth, A., Agner, E., & Rohde, M. (1997) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(97)00014-9 · Cited by 199 · see citing works
Jula, A., Marniemi, J., Huupponen, R., Virtanen, A., Rastas, M., & Rönnemaa, T. (2002) · JAMA · doi:10.1001/jama.287.5.598 · Cited by 198 · see citing works
Effect of coenzyme Q10 supplementation on simvastatin-induced myalgia
Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., George, P. M., & Scott, R. S. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.06.030 · Cited by 185 · see citing works
Effect of Coenzyme Q10 supplementation on statin-induced myalgias
Bookstaver, D. A., Burkhalter, N. A., & Hatzigeorgiou, C. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.04.026 · Cited by 89 · see citing works
Coenzyme Q<sub>10</sub>and selenium in statin-associated myopathy treatment
Fedacko, J., Pella, D., Fedackova, P., Hänninen, O., Tuomainen, P., Jarcuska, P., Lopuchovsky, T., Jedlickova, L., Merkovska, L., & Littarru, G. P. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0118 · Cited by 76 · see citing works
Šabovič, M. (2014) · Medical Science Monitor · doi:10.12659/msm.890777 · Cited by 75 · see citing works
Interactions between ubiquinones and vitamins in membranes and cells
Constantinescu, A., Maguire, J. J., & Packer, L. (1994) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(94)90013-2 · Cited by 73 · see citing works
Bargossi, A., Grossi, G., Fiorella, P. L., Gaddi, A. V., Giulio, R. D., & Battino, M. A. (1994) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(94)90028-0 · Cited by 69 · see citing works
No effect of combined coenzyme Q10 and selenium supplementation on atorvastatin-induced myopathy
Bogsrud, M. P., Langslet, G., Ose, L., Arnesen, K.-E., Sm stuen, M. C., Malt, U. F., Woldseth, B., & Retterstøl, K. (2013) · Scandinavian Cardiovascular Journal · doi:10.3109/14017431.2012.756119 · Cited by 53 · see citing works
de Lorgeril, M., Salen, P., Bontemps, L., Bélichard, P., GEYSSANT, A., & Itti, R. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199903000-00018 · Cited by 51 · see citing works
Interactions Between Ascorbyl Free Radical and Coenzyme Q at the Plasma Membrane
Arroyo, A., Navarro, F., Gómez-Dı́az, C., Crane, F. L., Alcain, F. J., Navas, P., & Villalba, J. M. (2000) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005568132027 · Cited by 47 · see citing works
Miyake, Y., Shouzu, A., Nishikawa, M., Yonemoto, T., Shimizu, H., Omoto, S., Hayakawa, T., & Inada, M. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1300422 · Cited by 47 · see citing works
Oh, V. M. S. (1998) · BMJ · doi:10.1136/bmj.316.7141.1396b · Cited by 46 · see citing works
Gross, J. B. (2004) · Survey of Anesthesiology · doi:10.1097/01.sa.0000119601.77789.60 · Cited by 45 · see citing works
Statin-Associated Myopathy with Normal Creatine Kinase Levels
Phillips, P. S., & Haas, R. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-12-200306170-00024 · Cited by 32 · see citing works
Statin-associated myopathy with normal creatine kinase levels
Phillips, P. S., Haas, R., & Bannykh, S. (2003) · ACC Current Journal Review · doi:10.1016/s1062-1458(02)01009-7 · Cited by 29 · see citing works
三宅, 豊. (1999) · Medical Entomology and Zoology · doi:10.11501/3176016 · Cited by 27 · see citing works
Landstad, K. S. B. J. (2001) · Journal of Rehabilitation Medicine · doi:10.1080/165019701750419617 · Cited by 18 · see citing works
Effect of Coenzyme Q10 on Myopathic Symptoms in Patients Treated With Statins
Howard, W. J. (2008) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)79111-x · Cited by 16 · see citing works
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1 of the 29 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Banach M, Serban C, Sahebkar A, Ursoniu S, Rysz J, Muntner P, Toth PP, Jones SR, Rizzo M, Glasser SP, Lip GY, Dragan S, Mikhailidis DP; Lipid and Blood Pressure Meta-analysis Collaboration Group. Effects of Coenzyme Q10 on Statin-Induced Myopathy: A Meta-analysis of Randomized Controlled Trials. Mayo Clin Proc 2015;90:24-34.
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Qu, H., Guo, M., Chai, H., Wang, W., Gao, Z., & Shi, D. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009835 · Cited by 178 · see citing works
Kennedy, C., Köller, Y., & Surkova, E. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.03.006 · Cited by 51 · see citing works
Schweitzer, A. M., Gingrich, M. A., Hawke, T. J., & Rebalka, I. A. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04360-2 · Cited by 18 · see citing works
- Authors
- Rott, D., Leibowitz, D., Goldenberg, I., & Klempfner, R.
- Affiliations
- Sheba Medical Center (IL)
- Hadassah Medical Center (IL)
- Venue
- Journal of Preventive Medicine And Care
- Publisher
- Open Access Pub
- Published
- 2016
- Volume
- 1
- Issue
- 1
- Pages
- 16-22
- ISSN
- 2474-3585 (ISSN-L)
- OpenAlex
- W2567135716
- Cited by
- 3
- References
- 29
- Citations by year
- 2020: 2 · 2018: 1
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Preventive Medicine And Care (publishedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Keywords
- coenzyme Q10, statin-induced myalgia, statin adverse effects, statin intolerance, myopathy, lipid-lowering therapy, coenzyme Q10 supplementation, LDL cholesterol lowering
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