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Cited by 922Helicobacter pylori-related gastroenterology studiesGastrointestinal Bleeding Diagnosis and TreatmentHepatitis C virus research

The DOI matches its Crossref record; 22 of the 23 references it cites were found in a registry or an index.

Cure of duodenal ulcer associated with eradication of Helicobacter pylori

Rauws, E.A.J., Tytgat, G.N.J.·1990·The Lancet
DOI 10.1016/0140-6736(90)91301-p
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Abstract

50 patients with intractable duodenal ulcer were randomly assigned to 4 weeks of treatment with colloidal bismuth subcitrate (CBS) alone (26 patients) or with amoxicillin and metronidazole (24 patients). 5 patients (all on triple therapy) withdrew because of side-effects. In 17 of the 45 patients who completed the treatment, Helicobacter pylori was eradicated, and there was no ulcer relapse during the first 12 months of follow-up. The ulcer relapse rate was significantly higher (17 of 21 [89%]) among patients who remained positive for H pylori. 9 patients who remained positive for H pylori and had ulcer relapses within 6 months of treatment with CBS alone, were subsequently given triple therapy. 7 of the 9 showed H pylori eradication and no relapses within the next 12 months. The 2 patients still H pylori-positive after triple therapy had further ulcer relapses. H pylori eradication, without altering acid output, will become the mainstay of duodenal ulcer treatment because it cures the disease.

Overview

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Crossref · 10.1016/0140-6736(90)91301-p

Cites

22 of 22 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 23 references

Research works printed but not linked: 3

  1. Lambert, 1987, Effect of colloiad bismuth (De-Nol) and healing relapse of duodenal ulcer-role of Campylobacter pyloridis., Gastroenterology, 92, 1489
  2. Borody, 1988, Long term Campylobacter pylori recurrence post-eradication, Gastroenterology, 94, 43
  3. Smith, 1988, A comparison of ranitidine and tripotassium dicitrato-bismuth (TDB) in relapse rate of duodenal ulcer. The role of Campylobacter pylori, Gastroenterology, 94, 431

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Metadata

Authors
Rauws, E. A. J., & Tytgat, G. N. J.
Affiliations
Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author
Rauws, E.A.J.
Venue
The Lancet
Publisher
Elsevier BV
Published
1990-05
Volume
335
Issue
8700
Pages
1233-1235
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/0140-6736(90)91301-p
OpenAlex
W2029865847
Cited by
922
References
23
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 12 · 2016: 13 · 2015: 10 · 2014: 18 · 2013: 11 · 2012: 14
FWCI
106.47
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Keywords
duodenal ulcer, Helicobacter pylori eradication, bismuth subcitrate, amoxicillin, metronidazole, triple therapy, ulcer recurrence
MeSH terms
Administration, Oral, Amoxicillin, Anti-Ulcer Agents, Campylobacter, Campylobacter Infections, Drug Administration Schedule, Drug Evaluation, Drug Therapy, Combination, Duodenal Ulcer, Follow-Up Studies, Gastric Mucosa, Humans, Metronidazole, Organometallic Compounds, Prospective Studies, Recurrence, Randomized Controlled Trials as Topic

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