When the ostrich-algorithm fails: blanking method affects spike train statistics.
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Abstract
. This stimulation produces undesired artifacts and can render the recorded signal only partially useful. The extent of these artifacts is often reduced by temporarily grounding the recording input during stimulation pulses. In the following study, we quantify the effects of this method, "blanking," on the spike count and spike train statistics. Starting from a theoretical standpoint, we calculate a loss in the absolute number of action potentials, depending on: width of the blanking window, frequency of stimulation, and intrinsic neuronal activity. These calculations were then corroborated by actual high signal to noise ratio (SNR) single cell recordings. We state that, for clinically relevant frequencies of 130 Hz (used for movement disorders) and realistic blanking windows of 2 ms, up to 27% of actual existing spikes are lost. We strongly advice cautioned use of the blanking method when spike rate quantification is attempted. IMPACT STATEMENT: Blanking (artifact removal by temporarily grounding input), depending on recording parameters, can lead to significant spike loss. Very careful use of blanking circuits is advised.
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The artifact problem is worse in multi-channel neural recording and stimulation circuits.
“This situation is even worse in the multi-channel neural recording and stimulation circuit (Ng et al., 2012; Joseph et al., 2018).”
From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Joseph et al., 2018
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Ravi, V. M., Joseph, K., Wurm, J., Behringer, S. P., Garrelfs, N. W. C., d’Errico, P., Naseri, Y., Franco, P., Meyer‐Luehmann, M., Sankowski, R., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201900305 · Cited by 96 · see citing works
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Advances in Neural Recording and Stimulation Integrated Circuits
Li, J., Liu, X., Mao, W., Chen, T., & Yu, H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.663204 · Cited by 21 · see citing works
- Authors
- Joseph, K., Mottaghi, S., Christ, O., Feuerstein, T. J., & Hofmann, U. G.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Mottaghi, Soheil
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-04-30
- Volume
- 12
- Pages
- 293-293
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC5946007
- OpenAlex
- W2952891224
- Cited by
- 3
- References
- 55
- Citations by year
- 2023: 1 · 2021: 1 · 2019: 1
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- blanking, stimulation artifacts, spike train statistics, single-unit recording, stimulation frequency, movement disorders
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