E. coli-mediated gut inflammation in genetically predisposed Crohn's disease patients
Abstract
Many advances have been made in the understanding of Crohn's disease (CD) pathogenesis over the last decade. In CD patients abnormal ileal bacterial colonization could be linked to inappropriate innate immune responses to invasive bacteria. Adherent and invasive Escherichia coli strains have been isolated from CD patients and are able to adhere to and to invade intestinal epithelial cells and to induce colitis in transgenic mice expressing the human CEACAM6 molecule. In this review, we report recent advances concerning the involvement of adherent-invasive E. coli in the aetiology of CD and analyze how they can initiate inflammation of the gut mucosa in individuals with genetic predisposition.
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Increased numbers of E. coli, including pathogenic variants, have been documented in ileal CD.
“More specifically, increased numbers of E. coli, including pathogenic variants, have been documented in ileal CD.68”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [68]
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Jiang, W., Liu, J., Zhao, X., & Yang, W. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01073-0 · Cited by 21 · see citing works
Alhagamhmad, M. H. (2018) · Nutrition in Clinical Practice · doi:10.1002/ncp.10004 · Cited by 14 · see citing works
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Mikrobiom und entzündliche Darmerkrankungen
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Importance of Bacteria as Trigger in Inflammatory Bowel Disease
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Self-citationIntestinal Microbiology and Ecology in Crohn’s Disease and Ulcerative Colitis
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Tryptophan metabolites and the microbiome-gut-brain axis in major gut disorders
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Relação entre a Infeção por Escherichia coli Aderente-Invasina e a Doença de Crohn
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Revealing gut microbiota metabolism with dietary glycan-fluorophore conjugates
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Subclinical Canine Chronic Enteropathy: Early Detection and Prevention is the Key to Cure
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- Authors
- Barnich, N., Denizot, J., & Darfeuille-Michaud, A.
- Affiliations
- Institut National de la Recherche Agronomique (MA)
- Corresponding author
- Barnich, N.
- Venue
- Pathologie Biologie
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 61
- Issue
- 5
- Pages
- e65-e69
- ISSN
- 0369-8114 (ISSN-L)
- OpenAlex
- W2072346088
- Cited by
- 34
- References
- 67
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pathologie Biologie (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Keywords
- Crohn's disease, adherent-invasive Escherichia coli, intestinal inflammation, genetic susceptibility, CEACAM6, intestinal epithelial cell invasion, innate immune response, colitis, transgenic mouse model
- MeSH terms
- Animals, Bacterial Adhesion, Colitis, Crohn Disease, Escherichia coli, Escherichia coli Infections, Humans, Ileum, Inflammation, Intestinal Mucosa, Mice, Transgenic, Antigens, CD, Cell Adhesion Molecules, Genetic Predisposition to Disease, Irritable Bowel Syndrome, Mice, GPI-Linked Proteins
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