Cited by 34Inflammatory Bowel DiseaseGut microbiota and healthEscherichia coli research studies

E. coli-mediated gut inflammation in genetically predisposed Crohn's disease patients

Barnich, N., Denizot, J., Darfeuille-Michaud, A.·2013·Pathologie Biologie

Abstract

Many advances have been made in the understanding of Crohn's disease (CD) pathogenesis over the last decade. In CD patients abnormal ileal bacterial colonization could be linked to inappropriate innate immune responses to invasive bacteria. Adherent and invasive Escherichia coli strains have been isolated from CD patients and are able to adhere to and to invade intestinal epithelial cells and to induce colitis in transgenic mice expressing the human CEACAM6 molecule. In this review, we report recent advances concerning the involvement of adherent-invasive E. coli in the aetiology of CD and analyze how they can initiate inflammation of the gut mucosa in individuals with genetic predisposition.

Integrity signals

Registry

Crossref · 10.1016/j.patbio.2010.01.004

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Increased numbers of E. coli, including pathogenic variants, have been documented in ileal CD.

    “More specifically, increased numbers of E. coli, including pathogenic variants, have been documented in ileal CD.68”

    From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [68]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Barnich, N., Denizot, J., & Darfeuille-Michaud, A.
Affiliations
Institut National de la Recherche Agronomique (MA)
Corresponding author
Barnich, N.
Venue
Pathologie Biologie
Publisher
Elsevier BV
Published
2013-10
Volume
61
Issue
5
Pages
e65-e69
ISSN
0369-8114 (ISSN-L)
OpenAlex
W2072346088
Cited by
34
References
67
Citations by year
2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
0.17
Type
journal article
Language
en
Open access
closed
Locations
  • Pathologie Biologie (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Keywords
Crohn's disease, adherent-invasive Escherichia coli, intestinal inflammation, genetic susceptibility, CEACAM6, intestinal epithelial cell invasion, innate immune response, colitis, transgenic mouse model
MeSH terms
Animals, Bacterial Adhesion, Colitis, Crohn Disease, Escherichia coli, Escherichia coli Infections, Humans, Ileum, Inflammation, Intestinal Mucosa, Mice, Transgenic, Antigens, CD, Cell Adhesion Molecules, Genetic Predisposition to Disease, Irritable Bowel Syndrome, Mice, GPI-Linked Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review