Physiological preparation for studying the response of subcutaneously implanted glucose and oxygen sensors
Abstract
A physiological preparation has been developed for studying the response of glucose end oxygen sensors chronically implanted in subcutaneous tissues. The preparation employs a chamber permanently mounted on the back of a rat that supports the growth of vascularized subcutaneous tissue around the sensors and is used in conjunction with chronic intravascular catheters for blood sampling and fluid infusion. A total of 26 glucose and oxygen sensors were implanted in nine chambers. At 10 days, the tissue surrounding the sensors was cellular, well vascularized and permeable. Glucose sensors responded to glucose infusions with a 10-15 minute lag.
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The optical tissue window enables tissue monitoring and correlation with sensor performance.
“The optical tissue window enables tissue monitoring and correlation to the sensor performance.116–118”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [117]
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- Authors
- Ertefai, S., & Gough, D. A.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Gough, D.A.
- Venue
- Journal of Biomedical Engineering
- Publisher
- IOP Publishing
- Published
- 1989-09-01
- Volume
- 11
- Issue
- 5
- Pages
- 362-368
- ISSN
- 0141-5425 (ISSN-L)
- OpenAlex
- W2018992015
- Cited by
- 52
- References
- 24
- Citations by year
- 2024: 1 · 2022: 1 · 2019: 1 · 2018: 2 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- Lee Foundation
- Charles Lee Powell Foundation
- National Institutes of Health
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- glucose sensor, oxygen sensors, subcutaneous implantation, chronic implantation, sensor response, glucose infusion, rat model, intravascular catheters
- MeSH terms
- Animals, Blood Glucose, Body Temperature, Connective Tissue, Foreign-Body Reaction, Male, Monitoring, Physiologic, Oxygen, Rats, Inbred Strains, Biosensing Techniques, Prostheses and Implants, Rats
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