Simulations of the Frequency Response of Implantable Glucose Sensors
Abstract
The response of enzyme electrode glucose sensors implanted in tissues to physiologic blood glucose oscillations is simulated. Models describe both oxygen-based and peroxide-based glucose sensors in spatially homogeneous medium simulating some mass transfer properties of tissue. Pass-through ratios and delays are reported as a function of frequency for the oxygen-based sensor, and the effects on continuous blood glucose monitoring are illustrated using data from the literature. Certain peroxide-based sensor designs may produce common signals for different glucose concentrations, a characteristic not found in oxygen-based sensors. The dynamic response depends on the frequency of glucose oscillation and is sensitive to sensor type, enzyme activity, and diffusional resistance.
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Jablecki and Gough's simulations concluded that increased mass transfer would increase lag and could potentially reduce the magnitude and differences when glucose sensor signals fluctuate between high and low.
“Simulations of glucose concentration oscillations by Jablecki and Gough concluded that increases in mass transfer would increase lag and could potentially decrease the magnitude and differences when fluctuating between high and low glucose sensor signals.110”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [110]
The positive correlation between lag time and capsule thickness supported the models described above.
“The positive correlation between lag time and capsule thickness supported the models described above.107,110–111”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [110]
The increases in mass transfer in those simulations were not attributed to any specific part of the FBR and could arise from collagen capsule thickness, blood vessel density, or other unanticipated factors.
“the increases to mass transfer were not attributed to any specific part of the FBR and could originate from collagen capsule thickness, blood vessel density, or other unanticipated factors.”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [110]
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- Authors
- Jablecki, M., & Gough, D. A.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Gough, David A.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-03-17
- Volume
- 72
- Issue
- 8
- Pages
- 1853-1859
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1971946532
- Cited by
- 24
- References
- 22
- Citations by year
- 2019: 1 · 2017: 2 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- implantable glucose sensor, frequency response, continuous glucose monitoring, sensor delay, diffusion resistance, sensor modeling
- MeSH terms
- Algorithms, Blood Glucose, Computer Simulation, Models, Biological, Biosensing Techniques
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