A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. II. Long‐term in vitro/in vivo sensitivity characteristics of sensors with NDGA‐ or GA‐crosslinked collagen scaffolds
Abstract
We have developed a new 3D porous and biostable collagen scaffold for implantable glucose sensors. The scaffolds were fabricated around the sensors and crosslinked using nordihydroguaiaretic acid (NDGA) or glutaraldehyde (GA) to enhance physical and biological stability. The effect of the scaffolds on sensor function and biocompatibility was examined during long‐term (≥28 days) in vitro and in vivo experiments and compared with control bare sensors. To evaluate the effect of the sensor length on micromotion and sensor function, we also fabricated short and long sensors. 3D porous scaffold application around glucose sensors did not significantly affect the long‐term in vitro sensitivity of the sensors. The scaffolds, crosslinked by either NDGA or GA, remained stable around the sensors during the 4 week in vitro study. In the long‐term in vivo study, the sensitivity of the short sensors was higher than the sensitivity of long sensors presumably because of less micromotion in the subcutis of the rats. The sensors with NDGA‐crosslinked scaffolds had a higher sensitivity than the sensors with GA‐crosslinked scaffolds. Histological examination showed that NDGA‐crosslinked scaffolds retained their physical structure with reduced inflammation when compared with the GA‐crosslinked scaffolds. Therefore, the application of NDGA‐crosslinked collagen scaffolds might be a good method for enhancing the function and lifetime of implantable biosensors by minimizing the in vivo foreign body response. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
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Histological analysis showed improved biocompatibility of NDGA-crosslinked scaffolds compared with GA-crosslinked scaffolds, with less inflammatory cell localization and infiltration.
“Histological analysis after the experiment revealed improved biocompatibility of the NDGA-crosslinked compared to the GA-cross-linked scaffolds as evidenced by less inflammatory cell localization and infiltration into the porous membranes.”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [148]
Despite the histological benefits, the analytical performance of control sensors lacking collagen was better than that of collagen-based sensors.
“Despite the observed histological benefits, the analytical performance of control sensors (i.e., lacking collagen) was better than that of the collagen-based sensors.148”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [148]
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- Authors
- Ju, Y. M., Yu, B., West, L., Moussy, Y., & Moussy, F.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Moussy, Francis
- Venue
- Journal of Biomedical Materials Research Part A
- Publisher
- Wiley
- Published
- 2009-02-20
- Volume
- 92A
- Issue
- 2
- Pages
- 650-658
- ISSN
- 1549-3296 (ISSN-L)
- 1552-4965
- OpenAlex
- W2054261405
- Cited by
- 52
- References
- 32
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research Part A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R01EB001640)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Keywords
- collagen scaffolds, implantable glucose sensor, nordihydroguaiaretic acid, glutaraldehyde, crosslinking, biocompatibility, foreign body reaction, sensor sensitivity, porous scaffolds, inflammation, subcutaneous implantation, sensor lifetime
- MeSH terms
- Animals, Biocompatible Materials, Collagen, Cross-Linking Reagents, Glutaral, Male, Materials Testing, Masoprocol, Biosensing Techniques, Porosity, Rats, Sprague-Dawley, Prostheses and Implants, Rats, Tissue Scaffolds
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