The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Photo-crosslinked copolymers of 2-hydroxyethyl methacrylate, poly(ethylene glycol) tetra-acrylate and ethylene dimethacrylate for improving biocompatibility of biosensors
Open accessAbstract
A copolymer containing 88% 2-hydroxyethyl methacrylate (HEMA), 9% poly(ethylene glycol) (MW 18.5 kDa) tetra-acrylate and 3% ethylene dimethacrylate was prepared and evaluated for use as a biocompatible interface between glucose biosensors and tissue in the rat. The glucose sensor utilizes glucose oxidase that is electrically 'wired' to a gold current collector by a reduction-oxidation polymer. Coatings of the copolymer were crosslinked in situ on the sensors using long wavelength ultraviolet light and 2,2-dimethoxy-2-phenyl-acetophenone as the initiator. The effect these films had on the current response to glucose was measured. Over a glucose concentration range of 0-30 mM, the average percentage decrease in response was 45 +/- 28% (mean +/- 95% confidence interval) at 37 degrees C for films that were about 0.1 mm thick, an acceptable value. Copolymer-treated and control electrodes were implanted in the intrascapular subcutaneous tissue of male Sprague-Dawley rats for three days. The explanted samples were evaluated using scanning electron microscopy. The control electrodes were highly encapsulated with fibrous material, while the copolymer-treated electrodes induced much less encapsulation. The results show this copolymer to be a candidate as a biocompatible coating for electrically wired oxidoreductase-based subcutaneous biosensors.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“substrates with the hydrogel coating had markedly less fibrous encapsulation relative to controls.143”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [143]
Citations
Cites
Design and in vitro studies of a needle-type glucose sensor for subcutaneous monitoring
Bindra, D. S., Zhang, Y., Wilson, G. S., Sternberg, R., Thevenot, D. R., Moatti, D., & Reach, G. (1991) · Analytical Chemistry · doi:10.1021/ac00017a008 · Cited by 309
Gregg, B. A., & Heller, A. (1991) · The Journal of Physical Chemistry · doi:10.1021/j100168a046 · Cited by 275
Self-citationDesai, N. P., & Hubbell, J. A. (1991) · Biomaterials · doi:10.1016/0142-9612(91)90193-e · Cited by 270
Self-citationRapid photopolymerization of immunoprotective gels in contact with cells and tissue
Pathak, C. P., Sawhney, A. S., & Hubbell, J. A. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00047a065 · Cited by 182
Self-citationApplication of Chronic Intravascular Blood Glucose Sensor in Dogs
Armour, J. C., Lucisano, J. Y., Bd, M., & Gough, D. A. (1990) · Diabetes · doi:10.2337/diab.39.12.1519 · Cited by 175
Sawhney, A. S., & Hubbell, J. A. (1992) · Biomaterials · doi:10.1016/0142-9612(92)90180-v · Cited by 156
Self-citationPishko, M. V., Michael, A. C., & Heller, A. (1991) · Analytical Chemistry · doi:10.1021/ac00020a014 · Cited by 148
Self-citationGombotz, W. R., Guanghui, W., & Hoffman, A. (1989) · Journal of Applied Polymer Science · doi:10.1002/app.1989.070370108 · Cited by 123
Elimination of electrooxidizable interferant-produced currents in amperometric biosensors
Maidan, R., & Heller, A. (1992) · Analytical Chemistry · doi:10.1021/ac00047a003 · Cited by 117
Self-citationPickup, J. C., Shaw, G. W., & Claremont, D. J. (1989) · Diabetologia · doi:10.1007/bf00265097 · Cited by 114
Cited by
Sorted by citations
Items 101–172 of 172
Mugweru, A. M., Clark, B. L., & Pishko, M. V. (2007) · Journal of Diabetes Science and Technology · doi:10.1177/193229680700100308 · Cited by 25
Park, S., Lee, Y., Kim, D. N., Park, S., Jang, E., & Koh, W. (2009) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2009.02.001 · Cited by 25
Initial Evaluation of a 290-μm Diameter Subcutaneous Glucose Sensor
Ishikawa, M., Schmidtke, D. W., Raskin, P., & Quinn, C. P. (1998) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(98)00011-7 · Cited by 25
Self-citationIn the trail of a new bio-sensor for measuring strain in bone: Osteoblastic biocompatibility
Carvalho, L., Alberto, N., Gomes, P. S., Nogueira, R. N., Pinto, J. L., & Fernandes, M. H. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.03.028 · Cited by 25
Means, A. K., Dong, P. X., Clubb, F. J., Friedemann, M. C., Colvin, L. E., Shrode, C. S., Coté, G. L., & Grunlan, M. A. (2019) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-019-6282-2 · Cited by 23
Ganesan, N., Gadre, A. P., Paranjape, M., & Currie, J. F. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.04.018 · Cited by 22
Thermal gellation and photo-polymerization of di-acrylated Pluronic F 127
Lee, S. Y., Tae, G., & Kim, Y. (2007) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856207782177855 · Cited by 21
Biocompatible polystyrenes containing pendant tetra(ethylene glycol) and phosphorylcholine groups
Kros, A., Gerritsen, M., Murk, J., Jansen, J. A., Sommerdijk, N. A. J. M., & Nolte, R. J. M. (2001) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/1099-0518(20010215)39:4 · Cited by 21
Kim, D., Lee, W., & Koh, W. (2008) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.2036 · Cited by 20
Electrochemical Redundant Microsensor Arrays for Glucose Monitoring with Patterned Polymer Films
Mugweru, A. M., Clark, B. L., & Pishko, M. V. (2007) · Electroanalysis · doi:10.1002/elan.200603749 · Cited by 20
A mathematical model for electrical impedance spectroscopy of zwitterionic hydrogels
Feicht, S. E., & Khair, A. S. (2016) · Soft Matter · doi:10.1039/c6sm01445c · Cited by 19
Li, Y., Li, L., Zeng, H., Lan, C., Yang, S., Zheng, Z., Zeng, M., Shi, Y., Gao, K., Cui, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61294-z · Cited by 18
Plasma-Enhanced Copolymerization of Amino Acid and Synthetic Monomers
Anderson, K., Young, S. L., Jiang, H., Jakubiak, R., Bunning, T. J., Naik, R. R., & Tsukruk, V. V. (2011) · Langmuir · doi:10.1021/la204416h · Cited by 17
Chemical Vapor Deposition of Polymer Films
Seidel, S., Riche, C. T., & Gupta, M. (2011) · Encyclopedia of Polymer Science and Technology · doi:10.1002/0471440264.pst467 · Cited by 17
Novel Dense CO2Technique for β-Galactosidase Immobilization in Polystyrene Microchannels
Ellis, J. L., Tomasko, D. L., & Dehghani, F. (2008) · Biomacromolecules · doi:10.1021/bm701343m · Cited by 16
Fabrication of macroporous hydrogel membranes using photolithography for enzyme immobilization
Choi, D., Lee, W., Lee, Y., Kim, D., Park, J., & Koh, W. (2007) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.1800 · Cited by 16
Electrochemical Glucose Sensors and Their Application in Diabetes Management
Heller, A., & Feldman, B. (2013) · Modern aspects of electrochemistry · doi:10.1007/978-1-4614-6148-7_5 · Cited by 16
Self-citationFabrication of Nanoindented Electrodes for Glucose Detection
Slaughter, G. E. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400212 · Cited by 16
Kim, D., Park, J., & Koh, W. (2009) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2008.08.001 · Cited by 14
Poveda‐Reyes, S., Rodrigo‐Navarro, A., Gamboa‐Martínez, T. C., Rodríguez‐Cabello, J. C., Quintanilla‐Sierra, L., Edlund, U., & Ferrer, G. G. (2015) · Polymer · doi:10.1016/j.polymer.2015.08.018 · Cited by 14
Chapter 12 Drug Delivery Applications
Sorgi, F. L., & Huang, L. (1997) · Current topics in membranes · doi:10.1016/s0070-2161(08)60216-6 · Cited by 13
Oh, W. T., Ham, J., Kim, S., & Koh, W. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.159250 · Cited by 12
Fabrication of hydrogel micropatterns by soft photolithography
Subramani, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-323-28990-0.00011-7 · Cited by 12
Electron transfer via redox hydrogels between electrodes and enzymes
Katakis, I., & Heller, A. (1997) · Experientia supplementum · doi:10.1007/978-3-0348-9043-4_15 · Cited by 12
Self-citationYuan, D., Lasagni, A. F., Shao, P., & Das, S. (2008) · Virtual and Physical Prototyping · doi:10.1080/17452750802615713 · Cited by 11
Mandal, H. K., Majumdar, T., & Mahapatra, A. (2011) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2011.03.001 · Cited by 10
Dyakonov, T., Huang, B., Hamoudi, A., Burns, D. H., Liu, Y., & Stevenson, W. T. K. (2000) · European Polymer Journal · doi:10.1016/s0014-3057(99)00256-6 · Cited by 10
Application of cellular micropatterns to miniaturized cell-based biosensor
Lee, H. J., Han, S. W., Chung, U. S., & Koh, W. (2013) · Biomedical Engineering Letters · doi:10.1007/s13534-013-0103-1 · Cited by 9
Evolution of the Artificial Pancreas: Components and Integration—CGMs, Insulin, and AP Systems
Bergenstal, R. M., Heller, A., Breton, M. D., Vigersky, R. A., Brown, S. A., Forlenza, G. P., Sherr, J. L., Hovorka, R., Russell, S. J., Damiano, E. R., et al. (2025) · Journal of Diabetes Science and Technology · doi:10.1177/19322968251342239 · Cited by 9
Self-citationDevelopment of Gold Nanoparticle Micropatterns for the Electrical Detection of Proteins
Lim, G., Kim, K., Park, Y., & Park, M. (2021) · Nanomaterials · doi:10.3390/nano11020528 · Cited by 8
Crulhas, B. P., Ramos, N. P., Basso, C. R., Costa, V. E., Castro, G. R., & Pedrosa, V. A. (2014) · International Journal of Electrochemical Science · doi:10.1016/s1452-3981(23)10990-4 · Cited by 8
Fluorescence-Based Glucose Biosensors
Coté, G. L., McShane, M. J., & Shih, W. (2008) · Series in medical physics and biomedical engineering · doi:10.1201/9781584889755.ch11 · Cited by 8
Chen, T., Schmidtke, D. W., & Heller, A. (2002) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2002.135 · Cited by 8
Self-citationSensor Biocompatibility and Biofouling in Real‐Time Monitoring
Voskerician, G., & Anderson, J. M. (2006) · Wiley eBooks · doi:10.1002/9780471740360.ebs1370 · Cited by 8
An X‐ray Spectromicroscopy Study of Albumin Adsorption to Crosslinked Polyethylene Oxide Films
Leung, B. O., Hitchcock, A. P., Brash, J. L., Schöll, A., & Doran, A. (2010) · Advanced Engineering Materials · doi:10.1002/adem.200980050 · Cited by 7
Packaging and coating materials for implantable devices
Wasikiewicz, J. M., Roohpour, N., & Vadgama, P. M. (2013) · Elsevier eBooks · doi:10.1533/9780857096289.1.68 · Cited by 7
Subramani, K., & Birch, M. A. (2009) · Journal of Biomimetics Biomaterials and Tissue Engineering · doi:10.4028/www.scientific.net/jbbte.2.3 · Cited by 5
Subramani, K., & Ahmed, W. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-7862-1.00011-0 · Cited by 5
Rapid fabrication of biocompatible hydrogels microdevices using laser interference lithography
Lasagni, A. F., Yuan, D., Shao, P., & Das, S. (2009) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.821099 · Cited by 5
Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers
Shin, B. C., Wisniewski, N. A., & Reichert, W. M. (2001) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856201300194216 · Cited by 5
Evolution of the Artificial Pancreas: Components and Integration—CGMs, Insulin, and AP Systems
Bergenstal, R. M., Heller, A., Breton, M. D., Vigersky, R. A., Brown, S. A., Forlenza, G. P., Sherr, J. L., Hovorka, R., Russell, S. J., Damiano, E. R., et al. (2025) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2025.18801.rmb · Cited by 5
Self-citationPrevascularized silicon membranes for the enhancement of transport to implanted medical devices
Worthington, K. S., Wiley, L. A., Mullins, R. F., Tucker, B. A., & Nuxoll, E. E. (2015) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33506 · Cited by 5
Zhang, S., Zhang, J., Shi, H., Gao, Z., & Kou, K. (2019) · Thermochimica Acta · doi:10.1016/j.tca.2019.178419 · Cited by 4
Fabrication of Hydrogel Micropatterns by Soft Photolithography
Subramani, K. (2010) · Elsevier eBooks · doi:10.1016/b978-0-8155-1583-8.00011-9 · Cited by 4
Recent Applications of Natural Polymers in the Formulation of Nanogel
Upadhyay, P., Agarwal, S., & Upadhyay, S. (2022) · Current Drug Therapy · doi:10.2174/1574885517666220421125043 · Cited by 3
Saux, G. L., Plawinski, L., Nlate, S., Ripoche, J., Buffeteau, T., & Durrieu, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150706 · Cited by 3
Improving the Biocompatibility of Implantable Bioelectronics Devices
Slaughter, G. E. (2014) · Wiley eBooks · doi:10.1002/9783527673148.ch13 · Cited by 4
Cell-Synthetic Surface Interactions
Koenig, A. L., & Grainger, D. W. (2002) · Elsevier eBooks · doi:10.1016/b978-012436636-7/50181-6 · Cited by 3
Cell Microarrays Based on Hydrogel Microstructures for the Application to Cell-Based Biosensor
Koh, W. (2010) · Methods in molecular biology · doi:10.1007/978-1-59745-551-0_7 · Cited by 2
Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime
Inoue, Y., Yokota, T., Sekitani, T., Kaneko, A., Woo, T., Kobayashi, S., Shibuya, T., Tanaka, M., Kosukegawa, H., Saito, I., et al. (2017) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1781-5 · Cited by 2
Miniaturized bioelectrochemical devices
Ghoorchian, A., Moradi, M., Aghajani, S., Afkhami, A., Madrakian, T., Thomas, S., Nguyen, T. A., & Ahmadi, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823727-4.00009-2 · Cited by 2
A novel biostable 3D porous collagen scaffold for implantable biosensor
Ju, Y. M. (2008) · Digital Commons - University of South Florida (University of South Florida) · Cited by 2
Preparation and Fuel Cell Performance of Proton Conductive Hydroxyapatite Doped Composite Membranes
MUROYAMA, K., Munakata, H., & Kanamura, K. (2007) · Electrochemistry · doi:10.5796/electrochemistry.75.807 · Cited by 1
Miniaturized electrochemical devices
Afkhami, A., Madrakian, T., & Ahmadi, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91741-4.00010-5 · Cited by 1
Boyd, B. W., & Kennedy, R. T. (2002) · doi:10.1201/9780203908907-19 · Cited by 1
Processing of Polymer Scaffolds
Dalton, P. D., Vijayasekaran, S., & Shoichet, M. S. (2002) · Elsevier eBooks · doi:10.1016/b978-012436636-7/50178-6 · Cited by 1
Soft Tissue Structure and Functionality
Voskerician, G. (2012) · Wiley eBooks · doi:10.1002/9781118129906.ch2
Redundant Arrays and Next‐Generation Sensors
Clark, B. L., & Pishko, M. V. (2009) · Wiley eBooks · doi:10.1002/9780470567319.ch8
Development of novel biocompatible hydrogel coatings for implantable glucose sensors
Wang, C. (2008) · Digital Commons - University of South Florida (University of South Florida)
Nuovi materiali funzionali per l'ingegneria del tessuto vascolare
Oliviero, O. (2008) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/1940
Microfabricated Multianalyte Sensor Arrays for Metabolic Monitoring
Pishko, M. V. (2006) · doi:10.21236/ada458979
A Novel Technique for Fabricating Plastic Lab-on-a-Chip Devices with an Immobilized Enzyme
Ellis, J. L. (2008) · The Knowledge Bank (The Ohio State University)
Dissolved oxygen and pH monitoring within cell culture media using a hydrogel microarray sensor
Lee, S. J. (2009) · OakTrust (Texas A&M University Libraries)
Introduction to a new silicone adhesive designed for wearables technologies
Poliskie, M., Fregoso, J., & Krizan, R. (2016) · IMAPSource Proceedings · doi:10.4071/isom-2016-poster7
Chapanian, R. (2009) · QSpace (Queen's University Library)
IDENTIFICATION OF NITRIC-OXIDE DEGRADATION PRODUCTS OF ASCORBIC ACID
Kolipaka, S. S. (2017) · doi:10.37099/mtu.dc.etdr/442
Acetone Sensing Based on Transmittance of Hydroxyethyl Methacrylate-Liquid Crystal Materials
Silalahi, H. M., Chiang, W. F., & Huang, C. Y. (2020) · Key engineering materials · doi:10.4028/www.scientific.net/kem.840.424
Campbell, C. N., Heller, A., Caruana, D. J., Schmidtke, D. W., Lunte, S. M., Martin, R. S., Lunte, C. E., Boyd, B. W., & Kennedy, R. T. (2002) · CRC Press eBooks · doi:10.1201/9780203908907.pt5
Self-citationSadana, A., & Sadana, N. (2015) · Elsevier eBooks · doi:10.1016/b978-0-444-53794-2.00006-9
Hydrogel-Based Biosensors in Biomedical Applications
Saha, H., Dey, B., & Hossain, K. R. (2025) · Biomaterials Connect · doi:10.69709/biomatc.2025.140011
Metadata
- Authors
- Quinn, C. P., Pathak, C. P., Heller, A., & Hubbell, J. A.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Hubbell, Jeffrey A.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 1995-01
- Volume
- 16
- Issue
- 5
- Pages
- 389-396
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1988024774
- Cited by
- 172
- References
- 19
- Citations by year
- 2025: 5 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (5r01dk042015-07)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK42015)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- 2-hydroxyethyl methacrylate, ethylene glycol dimethacrylate, glucose biosensor, biocompatibility, subcutaneous implantation, glucose oxidase, gold electrode, fibrous encapsulation, in situ crosslinking, 2,2-dimethoxy-2-phenylacetophenone
- MeSH terms
- Acrylates, Animals, Biocompatible Materials, Calibration, Cross-Linking Reagents, Glucose, Male, Methacrylates, Photochemistry, Polyethylene Glycols, Polymers, Ultraviolet Rays, Biosensing Techniques, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review