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Photo-crosslinked copolymers of 2-hydroxyethyl methacrylate, poly(ethylene glycol) tetra-acrylate and ethylene dimethacrylate for improving biocompatibility of biosensors
Open accessAbstract
A copolymer containing 88% 2-hydroxyethyl methacrylate (HEMA), 9% poly(ethylene glycol) (MW 18.5 kDa) tetra-acrylate and 3% ethylene dimethacrylate was prepared and evaluated for use as a biocompatible interface between glucose biosensors and tissue in the rat. The glucose sensor utilizes glucose oxidase that is electrically 'wired' to a gold current collector by a reduction-oxidation polymer. Coatings of the copolymer were crosslinked in situ on the sensors using long wavelength ultraviolet light and 2,2-dimethoxy-2-phenyl-acetophenone as the initiator. The effect these films had on the current response to glucose was measured. Over a glucose concentration range of 0-30 mM, the average percentage decrease in response was 45 +/- 28% (mean +/- 95% confidence interval) at 37 degrees C for films that were about 0.1 mm thick, an acceptable value. Copolymer-treated and control electrodes were implanted in the intrascapular subcutaneous tissue of male Sprague-Dawley rats for three days. The explanted samples were evaluated using scanning electron microscopy. The control electrodes were highly encapsulated with fibrous material, while the copolymer-treated electrodes induced much less encapsulation. The results show this copolymer to be a candidate as a biocompatible coating for electrically wired oxidoreductase-based subcutaneous biosensors.
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“substrates with the hydrogel coating had markedly less fibrous encapsulation relative to controls.143”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [143]
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Cites
Design and in vitro studies of a needle-type glucose sensor for subcutaneous monitoring
Bindra, D. S., Zhang, Y., Wilson, G. S., Sternberg, R., Thevenot, D. R., Moatti, D., & Reach, G. (1991) · Analytical Chemistry · doi:10.1021/ac00017a008 · Cited by 309
Gregg, B. A., & Heller, A. (1991) · The Journal of Physical Chemistry · doi:10.1021/j100168a046 · Cited by 275
Self-citationDesai, N. P., & Hubbell, J. A. (1991) · Biomaterials · doi:10.1016/0142-9612(91)90193-e · Cited by 270
Self-citationRapid photopolymerization of immunoprotective gels in contact with cells and tissue
Pathak, C. P., Sawhney, A. S., & Hubbell, J. A. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00047a065 · Cited by 182
Self-citationApplication of Chronic Intravascular Blood Glucose Sensor in Dogs
Armour, J. C., Lucisano, J. Y., Bd, M., & Gough, D. A. (1990) · Diabetes · doi:10.2337/diab.39.12.1519 · Cited by 175
Sawhney, A. S., & Hubbell, J. A. (1992) · Biomaterials · doi:10.1016/0142-9612(92)90180-v · Cited by 156
Self-citationPishko, M. V., Michael, A. C., & Heller, A. (1991) · Analytical Chemistry · doi:10.1021/ac00020a014 · Cited by 148
Self-citationGombotz, W. R., Guanghui, W., & Hoffman, A. (1989) · Journal of Applied Polymer Science · doi:10.1002/app.1989.070370108 · Cited by 123
Elimination of electrooxidizable interferant-produced currents in amperometric biosensors
Maidan, R., & Heller, A. (1992) · Analytical Chemistry · doi:10.1021/ac00047a003 · Cited by 117
Self-citationPickup, J. C., Shaw, G. W., & Claremont, D. J. (1989) · Diabetologia · doi:10.1007/bf00265097 · Cited by 114
Csöregi, E., Quinn, C. P., Schmidtke, D. W., Lindquist, S., Pishko, M. V., Ye, L., Katakis, I., Hubbell, J. A., & Heller, A. (1994) · Analytical Chemistry · doi:10.1021/ac00091a022 · Cited by 110
Self-citationPoitout, V., Moatti-Sirat, D., Reach, G., Zhang, Y., Wilson, G. S., Lemonnier, F., & Klein, J. C. (1993) · Diabetologia · doi:10.1007/bf00404077 · Cited by 95
Turner, R. F. B., Harrison, D. J., & Rojotte, R. V. (1991) · Biomaterials · doi:10.1016/0142-9612(91)90003-s · Cited by 91
Application of chronic intravascular blood glucose sensor in dogs
Armour, J. C., Lucisano, J. Y., Bd, M., et al. (1990) · Diabetes · doi:10.2337/diabetes.39.12.1519 · Cited by 74
In-vivo behaviour of hypodermically implanted microfabricated glucose sensors
Koudelka, M., Rohner‐Jeanrenaud, F., Terrettaz, J., Bobbioni-Harsch, E., de Rooij, N. F., & Jeanrenaud, B. (1991) · Biosensors and Bioelectronics · doi:10.1016/0956-5663(91)85005-h · Cited by 72
Grainger, D. W., Nojiri, C., Okano, T., & Kim, S. (1989) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820230903 · Cited by 54
Determination of urate in undiluted whole blood by enzyme electrode
Keedy, F. H., & Vadgama, P. M. (1991) · Biosensors and Bioelectronics · doi:10.1016/0956-5663(91)85046-y · Cited by 43
Poly(vinyl alcohol)-heparin hydrogels as sensor catheter membranes
Brinkman, E., Does, L. V. D., & Bantjes, A. (1991) · Biomaterials · doi:10.1016/0142-9612(91)90134-v · Cited by 34
Short-term in vivo operation of a glucose sensor.
Gough, D. A., Armour, J. C., Jy, L., & Bd, M. (1986) · PubMed · Cited by 21
Glucose electrochemical probe with extended linearity for whole blood
Mascini, M., Selleri, S., & Riviello, M. (1989) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/0731-7085(89)80158-x · Cited by 8
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Heller, A., & Feldman, B. (2008) · Chemical Reviews · doi:10.1021/cr068069y · Cited by 1,707
Self-citationPhotopolymerizable hydrogels for tissue engineering applications
Nguyen, K. T., & West, J. L. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00175-8 · Cited by 1,669
Enzymatic Biofuel Cells for Implantable and Microscale Devices
Barton, S. C., Gallaway, J., & Atanassov, P. B. (2004) · Chemical Reviews · doi:10.1021/cr020719k · Cited by 1,396
Biosensors for real-time in vivo measurements
Wilson, G. S., & Gifford, R. (2005) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2004.12.003 · Cited by 660
Heller, A. (2004) · Physical Chemistry Chemical Physics · doi:10.1039/b313149a · Cited by 660
Self-citation
Metadata
- Authors
- Quinn, C. P., Pathak, C. P., Heller, A., & Hubbell, J. A.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Hubbell, Jeffrey A.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 1995-01
- Volume
- 16
- Issue
- 5
- Pages
- 389-396
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1988024774
- Cited by
- 172
- References
- 19
- Citations by year
- 2025: 5 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (5r01dk042015-07)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK42015)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- 2-hydroxyethyl methacrylate, ethylene glycol dimethacrylate, glucose biosensor, biocompatibility, subcutaneous implantation, glucose oxidase, gold electrode, fibrous encapsulation, in situ crosslinking, 2,2-dimethoxy-2-phenylacetophenone
- MeSH terms
- Acrylates, Animals, Biocompatible Materials, Calibration, Cross-Linking Reagents, Glucose, Male, Methacrylates, Photochemistry, Polyethylene Glycols, Polymers, Ultraviolet Rays, Biosensing Techniques, Rats, Sprague-Dawley, Rats
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